Pharmaceutical Intermediate 4-Chlorothiophenol powder

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4-Chlorothiophenol powder Usage and Synthesis.

‌Pesticide and pharmaceutical intermediates‌: 4-Chlorothiol can be used as an important intermediate in the synthesis of pesticides and pharmaceuticals, participating in a variety of chemical reactions to generate the final product‌.

‌Plasticizers, oil additives and wetting agents‌: It is also widely used in the preparation of plasticizers, oil additives and wetting agents to improve the properties of these materials‌.

‌Dye intermediates‌: In dye synthesis, 4-Chlorothiol can be used as an important intermediate to participate in the preparation process of dyes‌.

Uses of 4-Chlorothiophenol powder.

‌Pharmaceutical and pesticide intermediates‌: 4-Chlorothiol can be used as an intermediate for pharmaceuticals and pesticides, participating in a variety of chemical reactions to produce important pharmaceutical and pesticide components‌.

‌Plasticizers, oil additives and wetting agents‌: It is also commonly used in the preparation of plastic plasticizers, oil additives and wetting agents to improve the performance of these products‌.

‌Dye intermediates‌: 4-Chlorothiol can also be used as an intermediate in dye production and participate in the dye synthesis process‌.

‌Organic synthesis reactions‌: In organic synthesis, 4-Chlorothiol can be used in a variety of chemical reactions, such as oxidation reactions with Co(salen) complex catalysts, sulfonamide Michael addition reactions of acryloxazolidinone catalyzed by thiourea, Pummerer-type cyclization reactions, C-H activation reactions and C-S cross-coupling reactions, etc.‌

Preparation of 4-Chlorothiophenol.

A method for preparing 4-chlorothiophenol, specifically: add 257.4g sodium p-chlorobenzenesulfonate, 7.7g tetrabutylammonium bromide, 642g toluene into a reactor, stir mechanically, then drop 168g thionyl chloride at room temperature, heat to 60°C after dropping, keep warm for 5h, and cool to room temperature.

Add 210.5g iron powder to the reaction solution in the previous step in batches, and drop 1176g sulfuric acid with a mass fraction of 60%, and control the reaction temperature between 40 and 50°C. After adding zinc powder and sulfuric acid, the reaction mixture is heated to 60°C and kept warm for 2h, followed by TLC tracking monitoring until the reaction is complete, cool to room temperature, and separate. The organic phase is distilled under reduced pressure to 120°C (-0.09MPa) to recover 598g toluene (repeatedly applicable), and crude 4-chlorothiophenol is obtained, and 200g n-hexane is added to reflux for 1h. The mixture was cooled and allowed to stand for 12 hours, and then centrifuged to obtain a solid. The solid was recrystallized to obtain pure 4-chlorothiophenol with a yield of 87.2%, a purity of 99.6%, and a melting point of 51-52.5°C.

Product method of Bulk 4-Chlorothiophenol.

Chlorobenzene is obtained by chlorosulfonation and reduction.

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