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Nicotinic acid Raw Materials, also known as vitamin B3, mainly found in animal viscera, muscle tissue, fruits, egg yolks also exist in trace amounts, is one of the 13 essential vitamins, belongs to the B vitamins, heat-resistant, can sublimate, is a kind of water-soluble vitamins.Nicotinic acid Powder in the human body can be converted into Nicotinamide can be converted into nicotinamide in human body, which is involved in the synthesis of coenzyme Ⅰ and coenzyme Ⅱ, and plays an important role in lipid metabolism, oxidation of tissue respiration and anaerobic decomposition of sugar in the body.
At present, Nicotinic acid CAS 59-67-6 is mainly used as feed additives, which can improve the utilization rate of feed protein, milk production of dairy cows and meat production and quality of fish, chicken, duck, cattle, sheep and other livestock. Nicotinic acid is also a widely used pharmaceutical intermediates, with its raw materials, you can synthesize a variety of pharmaceuticals, such as Nicosamide and nicotinic acid inositol ester. In addition, Nicotinic acid CAS 59-67-6 also plays an irreplaceable role in luminescent materials, dyes, electroplating industry and other fields.
Nicotinic acid CAS 59-67-6 is also known as Vitamin B3, or Vitamin PP, is heat-resistant and can sublimate. Nicotinic acid is also known as nicotinic acid and anti-mange factor. In the human body it also includes its derivative niacinamide or nicotinamide.Nicotinic acid Powder is one of the 13 essential vitamins, a water-soluble vitamin belonging to the vitamin B group.
Nicotinic acid Raw Materials is a precursor of the coenzymes NAD and NADP. It is widely distributed in nature and is found in large quantities in liver, fish, yeast and cereals. Dietary deficiencies have been associated with pellagra.Nicotinic acid Raw Materials is also used in niacinamide or other derivatives with niacin bioactivity. Vitamins (enzyme cofactors).
Applications / Functions of Nicotinic Acid Powder
Nicotinic acid Powder properties and stability
Nicotinic acid Powder white crystal or crystalline powder, odorless or slightly odor, taste slightly acidic. Melting point 234-237℃. Easily soluble in hot water, hot ethanol, alkaline water, propylene glycol and chloroform, slightly soluble in water and ethanol, soluble in 1.6g in 100mL water at room temperature, insoluble in ether and ester solvents. 1% aqueous solution PH is 3.0-4.0, stable to heat, acid and alkali. Oral LD505-7g/kg in rats, ADI value is not specified (ECC, 1990).
Production method of Nicotinic acid Powder
Nicotinic acid Powder occurs naturally in cereal germ, meat and peanuts, and is synthesized industrially by liquid-phase (potassium permanganate oxidation and nitric acid oxidation) and gas-phase (ozone oxidation, ammonia oxidation and air oxidation) methods.
3-Methylpyridine method
(1) Gas phase oxidation with ammonia. The 3-methylpyridine, air and ammonia are proportionally passed into the fluidized bed reactor, at 290-360 ℃, V2O5 catalyzed reflection to generate nicotinonitrile, and then hydrolyzed in aqueous sodium hydroxide at 160 ℃ to generate sodium nicotinate, and finally acidified with hydrochloric acid to get nicotinic acid.
(2) Potassium permanganate oxidation method. At 80 ℃, potassium permanganate is added into the mixture of 3-methylpyridine and water in batches, and then continue to stir the reaction at 85-90 ℃ for 30min, distillate to recover the unresponsive 3-methylpyridine, remove the manganese dioxide generated by filtration while hot, and the resulting potassium nicotinic acid solution is adjusted with hydrochloric acid PH to 3.8-4.0, cooled to 30 ℃, crystallization, filtration of the crude nicotinic acid. Dissolve the crude product in hot water, add activated carbon decolorization, filtration, cooling, crystallization of finished products, yield of about 86%. 6-hydroxyquinoline method will be sulfuric acid, quinoline added to the reactor, stirring and heating to 150-160 ° C and hold 5h, and then control the temperature at 180-220 ° C, slowly add nitric acid and sulfuric acid mixture, about 36-40h to add the whole, and then hold and stir 2-3h to get nicotinic acid solution, dilute the reaction solution with water, and then the reaction liquid with hydrochloric acid to adjust PH to 3.8-4.0, crystallization and filtration of nicotinic acid. The reaction solution is diluted with water, and then neutralized with 30%-33% NaOH solution to PH8-9. After cooling and filtering to remove sodium sulfate and sodium nitrate crystals, the filtrate is added to the copper sulfate solution, stirring, heating, the reaction generates copper nicotinate precipitate. Cooling, filtration will be added to the appropriate amount of copper nicotinate in water, dropwise addition of NaOH solution to PH greater than 9, the liquid phase does not show blue until the filtration to remove the generated copper oxide, filtrate to add a small amount of sodium sulfide solution (in order to remove trace amounts of copper and iron, etc.), to the solution does not produce a black precipitate until the solution, and filtration, and then the filtrate with hydrochloric acid adjusted PH to 3.5-3.9, crystallization, filtration of the crude nicotinic acid. Dissolve the crude product in 12 times the amount of distilled water, add activated carbon decolorization, filtration, cooling, clean, separated from the finished product nicotinic acid, the total yield of 35%-39%. 2-methyl-5-ethyl pyridine method takes 2-methyl-5-ethyl pyridine as raw material, oxidized by nitric acid under pressure and high temperature, then decarboxylated to produce nicotinic acid.
Nicotinic acid Raw Materials is obtained from 3-methylpyridine by oxidation and acidification. Another method using 3-methylpyridine as raw material is gas phase ammonia oxidation. Using a fluidized bed reactor, 3-methylpyridine, air and ammonia are mixed proportionally and reacted at 290-360 under the action of a vanadium catalyst. The fumonitrile obtained was hydrolyzed with sodium hydroxide at 160°C. If the hydrolysis is carried out with ammonia, the solubility of the hydrolysis is controlled to obtain nicotinic acid or nicotinamide, respectively. Nicotinic acid can also be produced from nicotine (tobacco). A fluidized bed reactor is used, with ferric ammonium citrate as catalyst, and gas-phase oxidation at 65-105°C with air. Nicotinic acid can also be produced industrially from quinoline, which is commonly oxidized and decarboxylated by ozone or oxidized and decarboxylated by nitric acid.
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