Aprepitant powder Raw Materials CAS 170729-80-3

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Uses and synthesis of Aprepitant powder

Aprepitant powder is a neurokinin-1 (NK-1) receptor antagonist, which belongs to the anti-cancer chemotherapy and vomiting treatment drug. Aprepitant CAS 170729-80-3 has a highly selective affinity for humans, but a low affinity for serotonin, dopamine and corticosteroids receptors. Aprepitant Raw Materials can selectively prevent the binding of substance P and NK-1 receptor in the central nervous system and play an antiemesis role, which is used for nausea and vomiting caused by moderate and high emesis chemotherapy drugs.

Applications/Functions of Aprepitant powder

Aprepitant powder can selectively prevent the binding of substance P and NK-1 receptor in the central nervous system and play an antiemetic role, which is used for nausea and vomiting caused by moderate and high emetic chemotherapy drugs.

Physicochemical Property of Aprepitant powder

Production methodprocess of Aprepitant powder

2-(R)-[1-(R)-[3, 5-bis (tetrafluoromethyl) phenyl] ethoxy]-3-(S)-(4-fluorophenyl) morpholine (R) camphor sulfonate and potassium carbonate dissolved in dimethylformamide, adding dimethylformamide solution of 3-chloromethyl-1,2, 4-triazoline-5-one at 22℃, stirring, adding water, and cooling with ice bath. The crystals were collected by filtration, washed and dried to obtain Aprepitant CAS 170729-80-3.

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