Factory Supply D-alpha-Tocopheryl acetate Powder CAS 58-95-7 Raw Materials

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Uses and synthesis of D-alpha-Tocopheryl acetate Powder

D-alpha-Tocopheryl acetate Powder has important physiological functions and is an essential nutrient for human body, which is widely used in pharmaceuticals, health care products, beauty care products, food and feed additives and other industries. Natural VE has four congeners called α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol. They all have the commonality of natural VE, but show different personalities, so they are differentiated in function and application fields. alpha-type monomer has the greatest biological activity, and has the best efficacy when used as pharmaceuticals and health care products. 

d-alpha-Tocopheryl acetate CAS 58-95-7 is one of the derivatives of d-alpha tocopherol, which continues the biological activity of d-alpha tocopherol, and is also used as a substitute for d-alpha tocopherol. D-alpha-Tocopheryl acetate CAS 58-95-7 is a derivative of D-alpha tocopherol and continues the biological activity of D-alpha tocopherol.

D-alpha-Tocopheryl acetate Raw Materials, or Vitamin E, is the name of a Western drug. D-alpha-Tocopheryl acetate Raw Materials, or Vitamin E, is the name of a western medicine. 

D-alpha-Tocopheryl acetate Powder is used for habitual abortion, preeclampsia, infertility and menopausal disorders; progressive muscular dystrophy, vulvovaginal atrophy and vulvovaginal pruritus, hemolytic anemia of prematurity, calf spasms, and intermittent claudication.。

Applications / Functions of D-alpha-Tocopheryl acetate Powder

D-alpha-Tocopheryl acetate Powder , also known as vitamin E acetate, is a common vitamin supplement. It is an ester of acetic acid and tocopherol (vitamin E) and is commonly used in skin care products such as skin creams. Tocopheryl acetate is not oxidized and can penetrate the skin into living cells, D-alpha-Tocopheryl acetate Raw Materials of which approximately 5% is converted to free tocopherol, providing beneficial antioxidant effects. Because the phenolic hydroxyl group is blocked, tocopheryl acetate is used as a substitute for tocopherol itself, thus providing a less acidic product with a longer shelf life. It is believed that once absorbed into the skin, the acetate is slowly hydrolyzed to regenerate the tocopherol and provide sun protection.

D-alpha-Tocopheryl acetate CAS 58-95-7 Biochemical Studies; Clinical Drugs are fat-soluble vitamins, clinically used in the treatment of habitual abortion, preeclampsia, infertility and menopausal disorders.

D-alpha-Tocopheryl acetate CAS 58-95-7 is the main raw material for a variety of VE health foods, and can be used as an intermediate in the synthesis of water-soluble vitamin E. It can be used as a raw material for the synthesis of water-soluble vitamin E. Although the antioxidant property of free VE is obviously higher than that of VE ester derivatives, the VE property of food or health food added with VE ester is not damaged in any way because VE ester is very easily hydrolyzed to the corresponding free VE by lipase catalyzed hydrolysis, and VE ester derivatives are applied to a series of industries such as food additives, pharmaceuticals, cosmetics, animal feeds, and nutritional fortification, etc., which is oriented to the huge VE market both at home and abroad. In view of the huge VE market at home and abroad, it is very urgent to expand the application development research of VE and the development of VE downstream products.

D-alpha-Tocopheryl acetate Powder properties and stability

D-alpha-Tocopheryl acetate CAS 58-95-7 yellowish or yellow transparent viscous liquid, almost odorless, easy to oxidize when exposed to light, the color becomes darker. Relative density d2540.950, refractive index (n20D) 1.4950-1.4972, the ethanol solution of this product in 284nm ± 1nm wavelength has the maximum absorption.

D-alpha-Tocopheryl acetate Raw Materials is soluble in oil, fat, ethanol, acetone, ether and chloroform, insoluble in water.

Production method of D-alpha-Tocopheryl acetate Powder

A method of preparing vitamin E acetate, characterized in that it comprises the following steps:

• (1) adding 2,3,5-trimethylhydroquinone and a catalyst consisting of concentrated sulfuric acid, copper sulfate and tin chloride to the reaction solvent, stirring until the material is dissolved, under the protection of N2, the temperature is controlled at 30-33°C, isophytol is added dropwise within 3-3.5h, dropwise addition is completed, the temperature is raised to 62-66°C, the holding reaction is held for 2.5h, the reaction is completed, the liquid is divided, the solvent is recovered by distillation under reduced pressure and the reaction solution is washed. Extraction of vitamin E, deionized water washing until the solution pH is 7, wherein the mass ratio of isophytol to 2,3,5-trimethylhydroquinone is 2-2.5:1, the mass ratio of copper sulfate to 2,3,5-trimethylhydroquinone is 0.045-0.05:1, the mass ratio of stannic chloride to 2,3,5-trimethylhydroquinone is 0.006-0.012:1, concentrated sulfuric acid to 2,3,5-trimethylhydroquinone is 0.006-0.012:1, concentrated sulfuric acid to 2,3,5-trimethylhydroquinone, concentrated sulfuric acid to 2,3,5-trimethylhydroquinone, concentrated sulfuric acid to 2,3,5-trimethylhydroquinone. 5-trimethylhydroquinone in a mass ratio of 0.2-0.4:1;
• (2) to the vitamin E layer after washing in step (2) add acetic anhydride and sodium borohydride, N2 protection, heating to 126-130 ℃ esterification reaction of 3.5h, the end of the reaction, decompression distillation recovery of acetic anhydride, cross washing with water and 70-80% methanol to the washout pH 7, washing twice, 50-60 ℃ concentration under reduced pressure, recovery of petroleum ether, concentrated, to get vitamin E acetate, wherein, acetic anhydride with 2, 3, 5-trimethylhydroquinone and 2, 3, 5-trimethylhydroquinone mass ratio of 0.2-0.4: 1. Wherein, the weight ratio of acetic anhydride to 2,3,5-trimethylhydroquinone is 2.3-2.7:1, and the amount of sodium borohydride added is 0.1-0.16% of the mass of acetic anhydride.

Phytol was condensed with 2,3,5-trimethylhydroquinone and then with acetic anhydride in the presence of zinc and sodium acetate to produce D-alpha-Tocopheryl acetate Raw Materials.

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