Colchicine powder Raw Materials CAS 64-86-8

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Uses and synthesis of Colchicine powder

Colchicine powder, also known as colchicine, is a kind of alkaloid extracted from the bulbs and seeds of colchicine in the liliaceae family. It naturally exists in Jialan and Shancimushroom in the hyacaceae family, with contents of 0.11% and 0.1%, respectively. Light yellow acicular crystal. Slightly smelly, bitter taste. Melting point 157℃, Colchicine CAS 64-86-8 easily soluble in cold water, alcohol, chloroform and formaldehyde, poor solubility in hot water, not easily soluble in benzene and ether, almost insoluble in petroleum ether, 0.5% solution pH is 5.9, after hydrolysis of ammonia water can reduce toxicity. Colchicine Raw Materials can inhibit cell mitosis and have anti-tumor effects.

Applications/Functions of Colchicine powder

1. Colchicine powder was used in plant genetics research. Used as a selenium reagent; Clinical use as an antitumor drug.
2. Colchicine CAS 64-86-8 is a typical mitotic toxin. For acute gout and for the treatment of breast cancer. It is also used as a selenium reagent for plant genetics and cancer research.
3. Colchicine Raw Materials are anti-gout and anti-tumor drugs for the treatment of acute gout and tumors
4. Colchicine powder can inhibit mitosis, destroy the spindle, and stop the chromosomes in the metaphase.

Physicochemical Property of Colchicine powder

Light yellow crystal or crystalline powder, smelly, bitter taste, see light discoloration. The maximum absorption wavelengths in ethanol are 243nm and 350.5nm. Colchicine CAS 64-86-8 soluble in water, ethanol and chloroform, soluble in benzene and ether, insoluble in petroleum ether, 0.5% solution of this product is weakly acidic.

Production methodprocess of Colchicine powder

Colchicine Raw Materials are alkaloids extracted from the bulbs of the liliaceous plant, the Lijiang Shancii Mushroom. Shanci mushrooms powder was heated with 85% ethanol for reflux extraction for 4h, and the obtained ethanol solution was concentrated into a semi-gel under reduced pressure, diluted with distilled water, extracted with chloroform after acidifying with 10% sulfuric acid, and then recrystalized the crude colchicine obtained by concentrating and crystallizing the chloroform extract.

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