Valsartan powder Raw Materials CAS 137862-53-4

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Uses and synthesis of Valsartan powder

Valsartan powder is an angiotensin receptor antagonist, which can be used for various types of hypertension and has a good protective effect on the heart, brain and kidney. For patients with hypertension such as myocardial infarction, heart failure, proteinuria, and diabetes, Valsartan can be used in combination with diuretics such as hydrochlorothiazide. Valsartan is a specific angiotensin II (AT1) receptor antagonist, and another non-skin AT1 receptor antagonist used in clinic after losartan, which plays a key role in regulating systemic blood pressure and maintaining electrolyte and fluid balance.

Applications/Functions of Valsartan powder

• Valsartan powder is a widely used antihypertensive drug in clinical practice. It has the advantages of little side effects and good tolerance, and can also be used for the treatment of hypertension in patients with diabetes and kidney disease.
• Valsartan antihypertensive drug. Non-peptide angiotensin II AT1-receptor antagonist. Used to treat high blood pressure.

Physicochemical Property of Valsartan powder

Production methodprocess of Valsartan powder

2' -cyanobiphenyl-4-aldehyde (I) and L-valine methyl ester were reduced by amination, the resulting compound (II) was acylated with valeryl chloride, and the compound (II) was obtained after chromatography. Then it reacts with Bu3SnN3, introduces tetrazole, and hydrolyzes to obtain Valsartan powder.

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