Obeticholic Acid powder Raw Materials CAS 459789-99-2

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Uses and synthesis of Obeticholic Acid powder

Obeticholic Acid powder, also known as 6-ethyl channedeoxycholic acid, is a novel derivative of channedeoxycholic acid (CDCA) in human primary bile acids. Obeticholic acid powder is a natural ligand of farnesate derivative X receptor (FXR). Obeticholic Acid is a farnesol X receptor agonist. Obeticholic acid indirectly inhibits cytochrome 7A1 (CYP7A1) gene expression by activating farnesol X receptor. Since CYP7A1 is a rate-limiting enzyme for cholic Acid biosynthesis, Obeticholic Acid can inhibit cholic acid synthesis for the treatment of primary biliary cirrhosis and non-alcoholic fatty liver disease.

Applications/Functions of Obeticholic Acid powder

1. Obeticholic Acid powder (OCA) is a potent agonist of synthetic modified bile acids and farnesoid X nuclear receptor (FXR) for the treatment of liver diseases, including primary cholangitis.
2. Since CYP7A1 is a rate-limiting enzyme for cholic Acid biosynthesis, Obeticholic Acid can inhibit cholic acid synthesis for the treatment of primary biliary cirrhosis and non-alcoholic fatty liver disease.

Physicochemical Property of Obeticholic Acid powder

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