Oxalyl Chloride powder Raw Materials CAS 79-37-8

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Oxalyl Chloride Usage and Synthesis:

Oxalyl Chloride is a colorless fuming liquid, soluble in ether, and decomposes violently in water and alcohol. When heated to about 600℃, it decomposes and releases carbon monoxide. It is soluble in hexane, benzene, ether, acetonitrile and halogenated solvents such as methylene chloride and chloroform. It is mainly used in the synthesis of pesticides and pesticide intermediates and in the synthesis of other organic chlorides. Oxalyl chloride is highly toxic and corrosive and can seriously irritate eyes, skin and respiratory tract. Contact with moisture is strictly prohibited. Oxalyl chloride can react violently with water to release toxic gases CO, CO2 and HCl.

Pharmacokinetics of Oxalyl Chloride:
Oxalyl Chloride is produced by reacting anhydrous oxalic acid with phosphorus pentachloride. After mixing phosphorus pentachloride with anhydrous oxalic acid, the reaction is slowly heated to about 64℃ until almost no hydrogen chloride is released, and the resulting crude product is then distilled to obtain oxalyl chloride. It is soluble in ether and decomposes violently when it meets water and alcohol. When heated to about 600℃, it decomposes and releases carbon monoxide. Soluble in hexane, benzene, ether, acetonitrile and halogenated solvents such as dichloromethane and chloroform. Anhydride compounds can also be obtained by adjusting the ratio of oxalyl chloride to carboxylate ions (formula 2) [2]. Oxalyl chloride interacts with metal organic compounds such as Grignard's reagent, alkyl lithium to produce o-dicarbonyl compounds.

Clinical Application of Oxalyl Chloride:
Oxalyl Chloride is used as an intermediate in the synthesis of benzoylurea insecticides such as flubenuron and chlorothalonil, and also as an intermediate in sulfonylurea herbicides such as metsulfuron, bensulfuron, and pyrimethanesulfuron. Oxalyl chloride is a widely used acylation reagent for the preparation of carbonyl chloride, phosphoryl dichloride, chlorinated alkanes, and acyl isocyanides. Oxalyl chloride is a very effective acylation reagent for the preparation of acyl azides, brominated olefins, carbamides, o-diazonaphthalenes, azo ketones, lactones, and for the realization of cycloaddition reactions of vinyl ketones, intramolecular Fridel-Crafts acylation reactions.

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