2-Picolinic acid powder Raw Materials CAS 98-98-6

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Uses and synthesis of 2-Picolinic acid powder

2-Picolinic acid powder is white needle-like crystal. The melting point is 134-136℃, easily soluble in glacial acetic acid, almost insoluble in ether, chloroform and carbon disulfide.

2-Picolinic acid CAS 98-98-6 is an important organic synthetic intermediate, used in the pharmaceutical industry for the preparation of carbocaine drugs and neurotics, 2-Picolinic acid Raw Materials has a wide range of applications in neuroleptics and local anaesthesia;

Applications / Functions of 2-Picolinic acid powder

1. Organic synthesis intermediates.
2. 2-Methylpyridine Potassium permanganate
3. Rare earth alkali metal chelates; 2-Picolinic acid powder Transition metal complexes for the preparation of picolinato ligands

Physicochemical Property of 2-Picolinic acid powder

White needle crystal. Melting point 134-136℃, easily soluble in glacial acetic acid, almost insoluble in ether, chloroform and carbon disulfide.

Production methodprocess of 2-Picolinic acid powder

1. Add 50g of 2-methylpyridine to 2500ml of water, heat and stir, add 90g of potassium permanganate, about 1h and then add the second 90g of potassium permanganate.
2. Add 500ml of water and continue heating for 2-2.5h until the purple colour disappears. Cool, filter out the manganese dioxide precipitate and wash with hot water. The filtrate was concentrated under reduced pressure and filtered.
3. The concentrate was acidified with concentrated hydrochloric acid to the acidity of Congo red and evaporated to dryness, which was checked and refluxed with 250ml of 95% ethanol for 1h.
4. Filtration, the filter cake was extracted with 95% ethanol, combined ethanol filtrate and extract, through the dry hydrogen chloride, until the crystals began to precipitate. Cooled to 10 ℃, and then pass hydrogen chloride to distillation and, filtered out 2-Picolinic acid CAS 98-98-6 

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