Celastrol powder Raw Materials CAS 34157-83-0

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Product details

Uses and synthesis of Celastrol powder

Celastrol powder, also known as Celastrol, is a natural product with various biological activities. Celastrol CAS 34157-83-0 has strong antioxidant, anti-cancer neovasculangiogenesis and anti-rheumatoid effects. Celastrol Raw Materials are mainly derived from the root bark of Tripterygium wilfordii.

Functions of Celastrol powder

• Celastrol powder has strong antioxidant, anti-cancer neovascularization and anti-rheumatoid effects.
• A potent proteasome inhibitor that has been shown to induce apoptosis of cancer cells by inhibiting proteasome activity

Applications of Celastrol powder

1. Anti-inflammatory and immunomodulatory ‌
Treat rheumatoid arthritis, exerting a potent anti-inflammatory effect by inhibiting NF-κB and inflammatory cytokines (such as iNOS)

Improve experimental colitis, regulate immune response by activating the autophagy pathway

‌2. Anti-tumor therapy ‌
Inhibit castration-resistant prostate cancer (CRPC) by downregulating AR signaling pathway and hERG channel expression

Induce apoptosis of triple-negative breast cancer (TNBC) cells, targeting PI3K/Akt/mTOR pathway

Enhance the sensitivity of lung cancer cells to DNA-damaging drugs by consuming FANCD2 protein

‌3. Metabolic disease intervention ‌
Significantly reduce obesity, reducing body weight by 45% by enhancing leptin sensitivity (mouse experiment)

‌4. Neuroprotection and degenerative diseases ‌
Inhibit dopaminergic neuron death in Parkinson's disease, activate mitochondrial apoptosis pathway

Penetrate the blood-brain barrier to regulate neuroinflammation in Alzheimer's disease

‌5. Research tool development ‌
Fluorescently labeled derivatives (such as FITC-Celastrol) for pharmacokinetic tracking and target validation

Biotinylated versions for proteomics and drug interaction studies

Physicochemical Property of Celastrol powder

Celastrol CAS 34157-83-0 is insoluble in water, but soluble in dimethyl sulfoxide and anhydrous ethanol.

Product method of Celastrol powder

Celastrol Raw Materials are derived from the anti-cancer active ingredients of Tripterygium wilfordii and Ophiodon wilfordii of Euonymaceae.

1. Natural extraction process ‌
‌Raw material selection‌: mainly extracted from the root bark of Celastraceae plants (such as Tripterygium wilfordii and Diplocopithecus strychnifolius)

‌Ultrasound-assisted extraction‌

Solvent: anhydrous ethanol
Conditions: temperature 46°C, ultrasonic power 60W, liquid-to-solid ratio 30mL/g, time 20 minutes, extraction rate 3.116mg/g3

‌Column chromatography purification‌
Three-step purification: polyamide column (methanol: water = 3:1) → silica gel column (petroleum ether: ethyl acetate gradient elution) → gel column (methanol elution), final purity > 98%

‌2. Chemical synthesis and modification‌
‌Glucosamine modification‌: Celastrol carboxyl is coupled to glucosamine by EDC/PyBOP activator to synthesize attenuated derivatives (Cel-GlcN)

‌3. Quality control‌
‌HPLC detection‌: The mobile phase is methanol-0.1% phosphoric acid water (88:12), the detection wavelength is 425nm, and the external standard method is used for quantification

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