Trimethoprim powder Raw Materials CAS 738-70-5

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Uses and synthesis of Trimethoprim powder

Trimethoprim powder is white or quasi-white crystalline powder. Odorless, bitter taste. Trimethoprim is slightly soluble in chloroform, slightly soluble in ethanol or acetone, and almost insoluble in water; Soluble in glacial acetic acid; An antimicrobial agent. The antibacterial range is similar to that of sulfanilamide. When used in combination with sulfanilamide, it can enhance its efficacy several times to dozens of times. Trimethoprim is suitable for respiratory tract infection, senile chronic bronchitis, dysentery, urinary system infection, enteritis, typhoid fever, malaria and other diseases. Trimethoprim powder is used as a feed additive and has obvious synergistic effect when combined with sulfonamides and anti-biological drugs, which can increase the effect by ten to ten times.

Applications/Functions of Trimethoprim powder

1. Trimethoprim powder, as an antibacterial synergist, can also treat bacterial infections and coccidiosis in poultry.
2. Dihydrofolate reductase inhibitors with prokaryotic enzyme selectivity are preferred as antibacterial agents. Specific dosage form inhibitors, Trimethoprim is widely used in the study of dihydrofolate reductase; Tetrahydrofolate synthesis is inhibited by prokaryotic specific dihydrofolate reductase (DHFR)

Physicochemical Property of Trimethoprim powder

Trimethoprim white crystalline powder, odorless, bitter taste. Melting point 199-203℃. Insoluble in water, ether, benzene, slightly soluble in chloroform, methanol, acetic acid.

Production methodprocess of Trimethoprim powder

Trimethoprim powder was synthesized from trimethoxybenzaldehyde by condensation with methoxypropanitrile to produce 3'4'5' -trimethoxy2-cyano-3-methoxypropene, and then by cyclic synthesis with guanidine nitrate in methanol/sodium methanol. 

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