Quinine powder Raw Materials CAS 130-95-0

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Uses and synthesis of Quinine powder

Quinine powder, also known as cinchona cream and cinchona alkali, is the main alkaloid in the bark of Cinchona tree and other plants of the rubiaceae family. Cinchona bark contains more than 20 kinds of alkaloids. In addition to quinine, Quinine and cinchonidine have anti-malaria effects. All alkaloids of cinchona bark are used as antimalarial drugs and antipyretic drugs, called cinchona alkaloid or cinchona quinine. Quinine chemically belongs to the quinoline family and is an isomer of quinidine. Quinine white amorphous powder or crystal, odorless, extremely bitter taste. It has a melting point of 172.8 ° C, and has left-handed optical activity, [α]D20-168°(ethanol). Soluble in ethanol, chloroform, benzene, ether, slightly soluble in water. Its dilute sulfuric acid solution has blue fluorescence, drop bromine water and excess ammonia water, that is, it appears emerald green.

Quinine powder was obtained by treating cinchona bark powder with lime and sodium hydroxide, extracting kerosene, neutralizing with dilute sulfuric acid, and reacting the precipitated quinine sulfate with ammonia. It can also be synthesized from m-hydroxybenzaldehyde and α-aminoacetaldehyde. Quinine powder is used for the treatment and prevention of various forms of malaria, medicinally as its sulfate or hydrochloride.

Applications/Functions of Quinine powder

1. Quinine powder is mainly used for patients infected with plasmodium that is resistant to chloroquine. It is also used in vivax malaria and falciparum malaria. All the salts used in medicine are quinine
2. Quinine is widely used as a wonder drug for malaria, and its antimalarial effect is similar to chloroquine, which works by interfering with DNA synthesis. It can inhibit the red blood cell phase of various plasmodium parasites and control the onset of malaria symptoms.

Physicochemical Property of Quinine powder

Quinine white amorphous powder or crystal, odorless, extremely bitter taste. It has a melting point of 172.8 ° C, and has left-handed optical activity, [α]D20-168°(ethanol). Soluble in ethanol, chloroform, benzene, ether, slightly soluble in water. Its dilute sulfuric acid solution has blue fluorescence, drop bromine water and excess ammonia water, that is, it appears emerald green.

Production methodprocess of Quinine powder

Quinine powder was obtained by treating cinchona bark powder with lime and sodium hydroxide, extracting kerosene, neutralizing with dilute sulfuric acid, and reacting the precipitated quinine sulfate with ammonia. It can also be synthesized from m-hydroxybenzaldehyde and α-aminoacetaldehyde.

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