Healthcare Supplement Pure Shikonin Lithospermum Extract Powder

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Uses and synthesis of Shikonin powder

Shikonin powder (shikonin, shikonin, porphyrin) is a kind of natural product with naphthoquinone structure extracted from the root of Shikonin, which has anti-inflammatory, antioxidant, anti-tumor and wound healing effects. In recent years, the antitumor effects of Shikonin and its derivatives have been extensively studied. Purple brown acicular crystal, soluble in pheneether, acetone, chloroform, methanol, ethanol, glycerin, animal and vegetable oil and alkaline aqueous solution, insoluble in water. Shikonin as a food colorant, China stipulates that it can be used for fruit juice (flavor) drinks, fruit wine, ice cream and popsicles, with the maximum usage of 0.1g/kg.

Applications and Functions of Shikonin powder

• Anti-tumor effect (potential): A large number of in vitro and animal experiments have shown that shikonin has an inhibitory effect on a variety of tumor cells, can inhibit tumor cell proliferation, induce tumor cell apoptosis, inhibit tumor angiogenesis, etc. However, the current human clinical trial data is still very limited, and the application of shikonin as an anti-tumor drug is still in the early research stage and cannot replace regular cancer treatment methods.
• Antioxidant effect: Shikonin has certain antioxidant activity, which can scavenge free radicals, reduce oxidative damage, and protect cells from damage.
• Anti-inflammatory effect: Shikonin has significant anti-inflammatory activity and can inhibit the release of a variety of inflammatory mediators, such as prostaglandins, leukotrienes, tumor necrosis factor α (TNF-α), etc., thereby reducing inflammatory responses. This may help alleviate the symptoms of a variety of inflammatory-related diseases.
• Antibacterial effect: Shikonin has an inhibitory effect on a variety of bacteria, especially Gram-positive bacteria, such as Staphylococcus aureus and Propionibacterium acnes. Its antibacterial mechanism may be related to destroying bacterial cell membranes and inhibiting bacterial protein synthesis.
• Antiviral effect: In vitro experiments have shown that shikonin has an inhibitory effect on certain viruses, such as herpes simplex virus, influenza virus, HIV virus, etc.

Benefits and Uses of Shikonin powder

• Promoting wound healing: This is the most traditional and mature application area of ​​shikonin. External preparations such as shikonin ointments and oils are widely used to treat various types of wounds such as burns, scalds, trauma, surgical incisions, etc., to accelerate wound healing and reduce scar formation. Many modern clinical studies have also confirmed the effectiveness of shikonin in promoting wound healing.
• Treatment of skin diseases: Shikonin is widely used to treat a variety of inflammatory skin diseases, such as eczema, dermatitis, acne, rosacea, psoriasis, etc. Its anti-inflammatory, antibacterial, and skin regeneration effects help relieve symptoms such as skin inflammation, itching, redness, swelling, and exudation, improve skin barrier function, and promote skin health. There are many skin care products and ointments containing shikonin on the market
• Anti-inflammatory and analgesic applications: Based on its anti-inflammatory and analgesic effects, shikonin can theoretically be used to relieve a variety of inflammatory and painful diseases, such as arthritis, muscle pain, neuralgia, oral ulcers, hemorrhoids, etc. There are also related applications in traditional medicine. However, there is relatively little evidence from modern clinical studies, and more high-quality clinical trials are needed to verify its efficacy.
• Anti-tumor application (under study): Although in vitro and animal experiments have shown the anti-tumor potential of shikonin, the current human clinical trial data are very limited and mostly early studies. Shikonin has not yet been approved for cancer treatment and cannot replace regular cancer treatment methods. The future application prospects of shikonin in the field of anti-tumor still need more in-depth research.

Production methodprocess of Shikonin powder

The roots of comfrey were extracted with 4 times the amount (mass) of refined soybean oil for 6min at 165 ~ 170 ℃, and then the extract was divided into 2 times with 95% ethanol (volume ratio), which was slightly more than the soybean oil. The ethanol extract was concentrated at a vacuum of 80kPa, and then the insoluble matter was filtered to obtain Shikonin powder.

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