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Uses and synthesis of Hyaluronic Acid Powder

Hyaluronic Acid Raw Materials, also known as hyaluronic acid, with the molecular formula (C14H21NO11)n, is a disaccharide unit glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine.]

Hyaluronic Acid Powder is a kind of acidic mucopolysaccharide, which was firstly isolated from the vitreous humor of cow's eye by Meyer et al, professor of ophthalmology of Columbia University, USA in 1934.

With its unique molecular structure and physicochemical properties, Hyaluronic Acid Powder displays a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating the diffusion of proteins, water and electrolytes and their operation, and promoting the healing of wounds.

Hyaluronic Acid CAS 9004-61-9 is a multifunctional matrix, hyaluronic acid (hyaluronic acid) HA is widely distributed in all parts of the body. Among them, the skin also contains a large amount of hyaluronic acid. Human skin maturation and aging process also changes with the content and metabolism of hyaluronic acid, Hyaluronic Acid CAS 9004-61-9 can improve skin nutrition metabolism, so that the skin is soft, smooth, wrinkle, increase elasticity, to prevent aging, in the moisturizing and at the same time, is a good transdermal absorption promoter.

Hyaluronic Acid CAS 9004-61-9 can be used in combination with other nutrients to promote the absorption of nutrients.

Applications / Functions of Hyaluronic Acid Powder

1. Hyaluronic Acid CAS 9004-61-9 is a biochemical drug with high clinical value, which is widely used in all kinds of ophthalmic surgeries, such as crystalline lens implantation, corneal transplantation and anti-glaucoma surgery. It can also be used to treat arthritis and accelerate wound healing. Used in cosmetics, it can play a unique role in protecting the skin, can keep the skin moisturized and smooth, delicate and soft, elastic, with anti-wrinkle, anti-wrinkle, beauty care and restoration of physiological functions of the skin.
2. Hyaluronic Acid Powder can be used in cosmetic creams, creams, honey, milk, masks, shampoos and other products to maintain the moisture of the skin and hair, moisturize the skin and hair, increase luster, and can prevent skin cracking and wrinkles. Hyaluronic acid skin cream reference formula and preparation process:Take stearic acid 7 7 g, liquid paraffin 1 0 . 5 g, white petroleum jelly 3 5 g, glycerol monostearate 3 5 g mixed, heated to 8 0 ° C, another 2 3 5 g of water, add sodium dodecyl sulfate 0 . 7 g and triethanolamine 2 . 4 5 g, heated to 8 0 °C, then add 1 0% nipaginol liquid 3 . 5 mL and glycerol 1 4 g. The oil phase was slowly poured into the aqueous phase, stirring in the same direction while pouring, and when the temperature was reduced to about 7 0 °C, 0 . 5% hyaluronic acid solution 2 2 0 mL poured into the above liquid, and add a little flavor, rapid stirring until semi-solid can be packaged.
3. Hyaluronic Acid Powder for arthritis and accelerated wound healing.

The effects and functions of Hyaluronic Acid Raw Materials:

• 1, Hyaluronic Acid Raw Materials has excellent affinity for water, which reorganizes the water inside the tissue to better bear the load or lubrication.
• 2, Folding occurs to form a three-dimensional network that produces physiological effects. These include generating fluid resistance, maintaining water balance in the body and stability of the internal environment, affecting the solubility, spatial configuration, chemical balance and systemic osmotic pressure of biological macromolecules, preventing pathogen playback, and directing the deposition of secretory substances in collagen fibers.
• 3, Hyaluronic Acid Raw Materials connects with proteins that cannot be separated to form aggregates to maintain the shape and volume of tissues and ensure the reversibility of tissues against compression force.
• 4, Hyaluronic Acid CAS 9004-61-9 has a certain effect on macrophages, mucous cells, lymphocytes, natural killer cells.
• 5, Hyaluronic Acid CAS 9004-61-9 is an important component of the intercellular matrix and is mainly degraded in the liver. When liver fibrosis is active, HA synthesis increases, coupled with reduced function in cirrhosis, so blood HA levels are abnormally high. Currently, HA is evaluated as a highly sensitive and specific indicator for diagnosing the degree of liver fibrosis and cirrhosis.

Hyaluronic Acid Powder properties and stability

Hyaluronic Acid CAS 9004-61-9 is white amorphous solid, odorless and tasteless, hygroscopic. Soluble in water, insoluble in organic solvents. The specific rotation of aqueous solution is -70°-80°.

Hyaluronic Acid Powder is most prominent in having high viscosity characteristics, the viscosity of its solution, when the following conditions, an irreversible decline can occur: pH below or above 7; hyaluronidase is present; many reducing substances, such as cysteine, pyrogallic gallic acid, ascorbic acid, or heavy metal ions are present; (4) ultraviolet light, electron beam irradiation, and so on. A polymer consisting of the disaccharide repeating unit of (1→3)-2-acetamido-2-deoxy-β-D-glucose-(1→4)-O-β-D-glucuronide, which on hydrolysis produces a hexosamine (e.g., glucosamine) and a glucuronide (e.g., glucuronide).

Originally used only as a biochemical reagent, it has now become a biochemical drug with high clinical value. It is widely found in nature in various tissues of animals: connective tissue, umbilical cord, skin, human serum, cockles, synovial fluid of joints, brain, cartilage, vitreous body of the eye, human urine, chicken embryo, rabbit oocytes, arteries and veins in the wall. Hyaluronic acid is often bound to proteins and coexists with other mucopolysaccharides. In vitreous humor and synovial fluid, it exists in a soluble form, and in cockles and umbilical cords as a gel.

Production method of Hyaluronic Acid Powder

The production process and technology of Hyaluronic Acid Powder determines the quality of the product, so it is important to use the product from the right source in order to have therapeutic benefits. Generally speaking, there are three methods of extraction.

• 1, animal tissues: the main raw materials are chicken crowns and cow's eye vitreous humor. With acetone or ethanol will be raw materials degreasing, dehydration, with distilled water immersion, filtration, and then treated with aqueous sodium chloride and chloroform solution, followed by adding trypsin insulation to get the mixture, and finally with ion exchange agent treatment, purification to get the refined hyaluronic acid. This method of extraction rate is very low, only about 1%, the separation process is complex, resulting in expensive hyaluronic acid, up to 5000 U.S. dollars / kg, limiting the use of large quantities in cosmetics.
• 2, microbial fermentation: glucose as a carbon source fermentation solution. Fermentation in the medium for 48 hours, after the end of fermentation, filtration to remove mycelium and impurities, and then alcohol precipitation method and other simple operations to obtain high-purity products. The advantage of hyaluronic acid manufactured by the fermentation method is that the molecular weight size can be set according to the commercial design. The key to the fermentation method lies in the selection of strains of bacteria, mostly streptococcus, lactococcus and so on.
• 3, chemical synthesis: the use of natural enzyme polymerization reaction; the first use of polysaccharide polymers to synthesize "hyaluronic acid oxygen azepine derivatives", and then add water decomposition enzyme to create a complex of derivatives and enzymes, and finally in the reaction solution at 90 degrees Celsius to remove the enzyme, the synthesis of hyaluronic acid. The use of synthetic methods can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less pure.

The same product of hyaluronic acid has a significant effect on the effect because of the difference in the source of raw materials and the technology of making it. The concentration of the product cannot be used as a reference for choosing a product. It is the purity, molecular weight, and 3D three-dimensional structure that will directly affect the water-absorbing effect of hyaluronic acid. Usually, the larger the molecular weight and the more complete the reticular structure, the better the water-absorbing effect. Maintenance products and cosmetics are popular in the market, but the hyaluronic acid made by many companies is cheap, but not necessarily effective. Some people even promote oral hyaluronic acid, after gastrointestinal absorption, it will be broken down into small unit molecules of carbohydrates and amino acids, or must be synthesized through the body in order to be generated in the skin, connective tissues, and its effect must also be discounted.

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