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Uses and synthesis of NMN Powder

Nicotinamide mononucleotide, also known as NMN Powder, is a substrate for the synthesis of coenzyme I. NMN has also been used in anti-aging research.

Studies have shown that NMN Powder CAS 1094-61-7 can also regulate insulin secretion and have an effect on mRNA expression levels, NMN Raw Materials has a wide range of applications in the field of medical therapy.

NMN Raw Materials is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate.NMN Powder improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression associated with oxidative stress, inflammatory responses, and circadian rhythms, in part through SIRT1 activation.

Nicotinamide mononucleotide, or NMN for short, is intrinsic to the human body and is also abundant in some fruits and vegetables, including broccoli and cabbage.

Applications / Functions of NMN Powder

In mammals, NMN Raw Materials are produced by the catalytic action of Nampt (a protease in the body), followed by the production of NAD+ from nicotinamide mononucleotides catalyzed by nicotinamide mononucleotide adenylyltransferase.

NMN Powder is a direct way to replenish NAD+, and it is by dramatically increasing the ability to repair DNA damage in cells that NMN Powder ultimately reverses the effects of aging.NMN Powder CAS 1094-61-7 is converted into nicotinamide adenine dinucleotide (NAD), a substance that is essential for energy metabolism in the body. "NMN Powder NMN Powder CAS 1094-61-7 converts nicotinamide adenine dinucleotide (NAD), which is essential for energy metabolism in the body, into a substance called nicotinamide adenine dinucleotide (NAD), which has been shown to activate a gene called acetylase in the body in mouse tests, thus producing a life-prolonging effect and treating diabetes.

NMN Powder CAS 1094-61-7 is the precursor of NAD+, a cofactor of longevity protein, which is an important coenzyme in the tricarboxylic acid cycle and promotes the metabolism of sugar, fat and amino acid, and participates in the synthesis of energy, and NAD+ is the only substrate of coenzyme I depletion enzyme (the only substrate of DNA repair enzyme PARP, the only substrate of longevity protein Sirtuins). NAD+ is the only substrate for Coenzyme I depletion enzymes (DNA repair enzyme PARP, longevity protein sirtuins, and cyclic ADP-ribose synthase CD38/157) NAD+ is involved in every aspect of human metabolism, and is a key coenzyme, without which metabolism fails, and when the elderly are deficient in NAD+, all kinds of major and minor ailments arise.

Preclinical studies have demonstrated multiple pharmacological activities of NMN Raw Materials in cardiac and cerebral ischemia, Alzheimer's disease, dietary and age-induced type 2 diabetes, and obesity. NMN Raw Materials, as a precursor drug to NAD+, primarily synthesizes NAD+ in the body to exert pharmacological effects, all of which are related to NAD+ deficiency.

NMN Powder properties and stability

NMN Raw Materials is a white to slightly yellow crystalline powder with no apparent odor.

NMN Raw Materials (full name β-nicotinamide mononucleotide) - "C11H15N2O8P", a molecule that occurs naturally in all forms of life. At the molecular level, it is ribonucleic acid, the basic structural unit of the nucleic acid RNA. Structurally, the molecule consists of a nicotinamide group, a ribose group and a phosphate group.NMN Powder is a direct precursor to the essential molecule nicotinamide adenine dinucleotide (NAD+), and is thought to be a key component in increasing intracellular NAD+ levels.

Production method of NMN Powder

NMN Powder was prepared by adding 150 ml of phosphate buffer solution in a 500 ml four-necked bottle. 2 g of MgCl2, 10 g of ATP, 7 g of ribose, 10 g of nicotinamide were added at once and kept at 35°C with stirring. The pH of the reaction system was detected and pH = 8.0 was adjusted with 10% Na2CO3 solution, then 1 g of RK enzyme powder and 2 g of NAMPT enzyme powder were added and stirred to dissolve. The reaction was stirred at 200 rpm at 37 °C, and the conversion rate of the reaction was monitored using liquid chromatography-mass spectrometry, and after 6 h of reaction, the reaction was stopped by detecting that ATP had been consumed. NMN Powder CAS 1094-61-7 can be obtained by further filtration, adsorption on HZ-818-type macroporous resin, lyophilization, and recrystallization from ethanol and water in 70% yield.

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