Factory Supply Folic Acid Powder CAS 59-30-3 Raw Materials

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Uses and synthesis of Folic Acid Powder

Folic Acid Raw Materials is the name of a western medicine. Commonly used in tablet form. It is an anti-anemia drug. Used for various causes of folic acid deficiency and folic acid deficiency caused by megaloblastic anemia; pregnancy, lactating women prophylaxis; chronic hemolytic anemia caused by folic acid deficiency.

Folic Acid Raw Materials is an important B water-soluble vitamin, isolated from spinach in 1941, and named for its very rich content in green leaves, also known as natriuretic glutamate. It exists in several forms in nature, and its parent compound is a combination of three components: nystatin, p-aminobenzoic acid and glutamic acid. Folic acid contains one or more glutamyl groups, and most naturally occurring folic acid is in the polyglutamic acid form. The biologically active form of folic acid is tetrahydrofolate.In 1981, the Committee on Nomenclature of the American Institute of Nutrition (CNAIN) referred to folic acid and related compounds with the biological activity of folic acid collectively as fo-lacin.Biological activity is generally expressed in weight units.

Folic Acid Powder is a dark yellow substance that is not readily soluble in water, and its sodium salt is more soluble. It is heat-stable in neutral and alkaline solutions, but decomposes in acidic solutions at temperatures exceeding 100°C. It is a dark yellow substance that does not dissolve easily in water, and its sodium salt is more soluble.

Folic Acid CAS 59-30-3 and its sodium salt are destroyed by light in solution. Folic acid isolated from liver and yeast is mainly derivatives containing three or seven glutamates. The vast majority of dietary folic acid is polyglutamate compounds that are not absorbed intact into the bloodstream. Experiments with pteroyl polyglutamate labeled with a second glutamyl residue in 14C were broken down to pteroylglutamate during absorption, and serum was free of radioactive folic acid, while exhaled gas contained 14 C. The breakdown of the polyglutamate chain takes place in the cells of the intestinal mucosa.Folic Acid CAS 59-30-3 is stored in small quantities in the liver. The 4-hydroxyl group in the pteridine nucleus is replaced by an amino group to become 4-amino folic acid, which is an antagonist of folic acid and hinders nucleic acid synthesis.Folic Acid CAS 59-30-3 is an antagonist of folic acid.

Folic Acid CAS 59-30-3, also known as vitamin B9, is a water-soluble vitamin.

0.4 mg folic acid is used for the prevention of fetal neural tube malformations, Splendid Folic Acid Project research, after 250,000 cases of China and the United States to prevent neural tube malformations cooperation project verification[1], mothers-to-be in the preparation for pregnancy to take 0.4 mg folic acid can be reduced by 85% of fetal neural tube malformations, the results of this result so far by more than 50 countries around the world are widely used. 5 mg folic acid is used to treat anemia in women, the consumer must read the instructions carefully when choosing to buy. When choosing to buy, consumers must carefully read the instructions and choose according to different situations.

Folic Acid CAS 59-30-3 one of the vitamin B complex, equivalent to pteroylglutamic acid (pteroylglutamic acid, PGA), is Mitchell (H. K. Mitchell, 1941) from the spinach leaf extraction purification, so named folic acid. It has the function of promoting the maturation of young cells in the bone marrow, and the lack of folic acid in human beings can cause megaloblastic anemia and leukopenia, which is especially important for pregnant women.

Applications / Functions of Folic Acid Powder

Folic Acid CAS 59-30-3 can improve megaloblastic anemia, and the safe intake of folic acid by pregnant women can prevent vascular sclerosis, fetal malformations and preterm delivery; in addition, pregnant women need to start supplementing folic acid in the first trimester of pregnancy in order to satisfy the needs of the gestation period, because folic acid can only be transformed to play a physiological role after 4 weeks of intake into the human body. Lactating women can promote milk secretion by supplementing folic acid. Supplementation of folic acid can improve tongue redness, swelling and pain, depression, fatigue, insomnia; to prevent intestinal parasites and food poisoning; to promote skin health, reproduction of oral mucosal ulcers; with pantothenic acid and p-aminobenzoic acid can prevent gray hair; when the body is weak to take can promote appetite.

• 1.Folic Acid Powder biochemical research; clinical drug for the vitamin B group, used in pregnancy and infantile megaloblastic anemia and other conditions of treatment.
• 2.Folic Acid Powder is an anti-anemia drug used for symptomatic or nutritional megaloblastic anemia.
• 3.Folic Acid Raw Materials are used as biochemical reagents, also used in pharmaceutical industry, etc.
• 4.Folic Acid Raw Materials are anti-anemia drugs. Livestock and poultry lack of folic acid, loss of appetite, growth inhibition, poor feather growth. Dosage 0.5-1.0mg/kg.
• 5. As food fortifier. It can be used in baby food, the dosage is 380-700μg/mg; the dosage in food for pregnant women and lactating mothers is 2-4mg/kg.
• 6.Folic Acid CAS 59-30-3 is an anti-anemia drug; it can also prevent most of the neural tube defects (NTDs).
• 7.Folic Acid CAS 59-30-3 is used as a biochemical reagent; as a food fortification agent; also used in the pharmaceutical industry and so on.
• 8.Folic Acid CAS 59-30-3 is used in polyamide industry to prepare nylon, also used as raw material of saturated polyurethane.
• 9.Folic Acid Raw Materials are used in feed, medicine and food, but mainly used in feed.
• 10.Folic Acid Powder Dihydrofolate reductase substrate

Folic Acid Powder properties and stability

Folic Acid Powder Orange needle-like crystals. No melting point, 250 ℃ carbonization. Stable to visible light, see ultraviolet light activity decreases, acid, alkali accelerated oxidative hydrolysis. Specific optical rotation [α] 25D+23°(0.5%, 0.1mol/L sodium hydroxide solution). The 0.1mol/L NaOH solution of this product has maximum absorption at 256nm, 283nm, 365nm. Insoluble in water, ethanol, ether and chloroform, slightly soluble in methanol, soluble in acetic acid, pyridine, alkali hydroxide and carbonic acid alkali solution.LD50 (rat, intravenous) 500mg/kg.

Production method of Folic Acid Powder

1. Folic Acid Powder is made from p-aminobenzoylglutamic acid, 2,4,5-triamino-6-hydroxypyrimidine and trichloroacetone in the presence of sodium metabisulphite and sodium acetate, keeping the Ph value of 3.4-3.6, the temperature of 36-40 ° C under the cyclic reaction for 6h to obtain orange-red folic acid precipitation. α,β-dibromopropionaldehyde can also be used instead of trichloroacetone, and the product is obtained by condensation under similar conditions.
2. Folic Acid Raw Materials was first extracted from liver leachate, but now it is produced by synthetic method. The synthetic method can first synthesize the pteridine nucleus and then condense it with p-aminobenzoylglutamic acid to obtain folic acid, or it can be obtained by reacting 2,4,5-triamino-6-hydroxypyrimidine, α,β-dibromopropionaldehyde, and p-aminobenzoylglutamic acid in a buffered solution of acetic acid-sodium acetate, and then purifying it to obtain folic acid containing two molecules of water of crystallization. Similar to the latter synthesis, p-aminobenzoylglutamic acid, trichloroacetone and 2,4,5-triamino-6-hydroxypyrimidinium sulfate ([1603-20-7]) were reacted in the presence of sodium acetate and sodium metabisulfite for 6h at a temperature of 36-40°C to give an orange-red folic acid precipitate by cyclization.
3. Folic Acid CAS 59-30-3 by p-aminobenzoylglutamic acid, 2,4,5-triamino-6-hydroxypyrimidine and trichloroacetone, in the presence of sodium metabisulfite and sodium acetate, keep pH 3.4-3.6, temperature 36-40 ℃ under the cyclization reaction 6h, get orange-red folic acid precipitate. Can also be used α,β-dibromopropionaldehyde instead of trichloroacetone, condensed under similar conditions to obtain the product.
4. Folic Acid CAS 59-30-3 is produced by condensation reaction with 2,4,5-triamino-6-hydroxypyrimidine, 2,3-dibromopropionaldehyde and p-aminobenzoylglutamic acid as main raw materials.

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