Factory Supply Coenzyme Q10 Powder CAS 303-98-0 Raw Materials

MF:C59H90O4

MW: 863.34

EINECS:206-147-9

Specification:Coenzyme Q10 Powder

Sample:Coenzyme Q10 Powder

Brand: Coenzyme Q10 Powder

Appearance: Yellow Powder

Storage: Cool Dry Place

Brand: Globalchemical

Shelf Life: 2 Years

Test Method: HPLC

Uses and synthesis of Coenzyme Q10 Powder

Coenzyme Q10 Raw Materials is a small molecule fat-soluble quinone organic compound found in a wide range of plant and animal cells. Its structure is similar to that of Vitamin K, and it is a powerful antioxidant when used alone or in combination with Vitamin E. Coenzyme Q10 Raw Materials is essential for driving the body's energy production (ATP) cycle.

Coenzyme Q10 Raw Materials is required to drive the body's energy production (ATP) cycle. It functions to promote oxidative phosphorylation reactions and protect the structural integrity of biological membranes. Different sources of Coenzyme Q have different numbers of side chain isoprenyl units, 10 isoprenyl units in humans and mammals, hence the name Coenzyme Q10.

Coenzyme Q10 CAS 303-98-0 plays an important role in proton translocation and electron transfer in the respiratory chain in vivo. It is an activator of cellular respiration and cellular metabolism, as well as an important antioxidant and non-specific immune enhancer.

Coenzyme Q10 Powder is a fat-soluble antioxidant, which can activate the nutrition of human cells and cellular energy, and has the functions of improving human immunity, enhancing antioxidant, slowing down the aging process, and enhancing human vitality, etc. It is widely used in cardiovascular diseases in medicine, and is also widely used in nutritional health care and food additives at home and abroad.

Applications / Functions of Coenzyme Q10 Powder

Coenzyme Q10 CAS 303-98-0 can be used as an endogenous cellular antioxidant; it is an important component of the electron transfer chain. It is also a coenzyme analog used as an adjunctive therapy for congestive heart failure, arrhythmias, sinus tachycardia, premature beats, hypertension and cancer;

Coenzyme Q10 Powder is used in the comprehensive treatment of acute and chronic viral hepatitis and subacute hepatic necrosis. It is also used in primary and secondary aldosteronism, cerebrovascular disorders and hemorrhagic shock. It can activate the nutrition of human cells and cellular energy, and has the ability to improve human immunity, enhance antioxidant, delay aging and enhance human vitality.

In addition, recent studies have shown that Coenzyme Q10 Powder also has anti-tumor effects, clinical for advanced metastatic cancer has a certain degree of efficacy, in the prevention of coronary heart disease, alleviate periodontitis, the treatment of duodenal ulcer and gastric ulcers, to enhance the human body's immune system function as well as the relief of angina pectoris has significant effects. It is widely used in pharmaceuticals, cosmetics, food additives and other industries.

• 1, Coenzyme Q10 Raw Materials can reduce the weakening of myocardial contraction force and the reduction of phosphocreatine and adenosine triphosphate content in acute ischemia, maintain the morphology and structure of mitochondria in ischemic cardiomyocytes, and have a certain protective effect on ischemic myocardium.
• 2、Coenzyme Q10 Powder increases cardiac output and reduces peripheral resistance, which is beneficial to the treatment of anti-heart failure, and may inhibit the synthesis and secretion of aldosterone and block its effect on renal tubules.
• 3、Coenzyme Q10 Powder can shorten the duration of action potential and produce ventricular arrhythmia threshold higher than that of control animals when perfusing isolated ventricular muscle of animals under hypoxic conditions.
• 4, Coenzyme Q10 CAS 303-98-0 can make the peripheral vascular resistance decrease, and have anti-aldosterone effect.
• 5, Coenzyme Q10 CAS 303-98-0 has anti-adriamycin cardiotoxic effect and hepatoprotective effect.

Coenzyme Q10 Powder properties and stability

Coenzyme Q10 Powder Yellow or orange-yellow crystalline powder; odorless and tasteless; easily decomposed when exposed to light.

Coenzyme Q10 CAS 303-98-0 is found in relatively high levels in organs (heart, liver, kidneys), beef, soybean oil, sardines, mackerel, and peanuts, etc. Consumption of approximately 1 pound of sardines, 2 pounds of beef, or 3 pounds of peanuts provides approximately 30 mg of Coenzyme Q10, respectively.

Coenzyme Q10 Raw Materials was discovered in 1957 and its chemical structure was determined in 1958 by Dr. Kaluforukas, who received the Priestly Medal, the highest honor of the American Chemical Society, and is known as the father of Coenzyme Q10 research, when he proposed that Coenzyme Q10 Raw Materials plays an important role in heart function. Coenzyme Q10 Raw Materials play an important role in heart function. In reality, Dr. Karuforukas, who took Q10 for 40 years until his death at the age of 91, has been energetically engaged in research activities as an active professor.

Production method of Coenzyme Q10 Powder

1. Method I. Alcohol - alkali saponification method of saponification solution preparation take pig heart residue, press dry weighing, according to the dry residue weight plus 300g / L industrial pyrogallic gallic acid, stir well, add alcohol - alkali solution (dry residue weight 3-3.5 times the amount of ethanol, 320g / L sodium hydroxide), heating and stirring reflux 25-30min, quickly cooled to room temperature, saponification solution. Pig heart residue [NaOH] → [pyrogallic gallic acid, ethanol] saponification liquid concentrate preparation Take the saponification liquid, immediately add its volume 1/10 amount of petroleum ether or 120 gasoline extracted 3-4 times, stirring, stratification, get the extract. Washed to nearly neutral, concentrated to 1/10 of the original volume at 40 ° C or below, cooled, -5 ° C or below the static overnight, filtration, to get the concentrate. Saponification solution [petroleum ether] → extract [<40 ° C] → concentrate coenzyme Q10 refined products preparation will be concentrated over silica gel column chromatography, successively eluted with petroleum ether, 10% ethyl ether - petroleum ether, collect the eluent, recover the solvent, get yellow oil. Heating anhydrous ethanol to dissolve, filtration, filtrate static, cooling crystallization, vacuum drying, coenzyme Q10 refined products. Concentrate [silica gel column, ether - petroleum ether] → eluent [anhydrous ethanol] → Coenzyme Q10 Powder refined products
2. Method II, alcohol - ether mixed solvent extraction method Coenzyme Q10 crude product preparation Take pig heart residue, add 1.5 times the amount of V ethanol: V ether = 3: 1 mixed solvent, heating extraction 3-4 times, each time 15-20min, cold to room temperature, filtration, and merge the extract. Concentrate, add appropriate amount of water, add petroleum ether extraction, the extract is concentrated, the concentrate is yellow oil, that is, Coenzyme Q10 crude products. Preparation of coenzyme Q10 finished products take coenzyme Q10 crude products, add acetone to dissolve, set -10 ℃ below the precipitation impurities, filtration, filtrate evaporation of acetone, add a small amount of petroleum ether to dissolve, over the silica gel column chromatography separation, add anhydrous ethanol crystallization, coenzyme Q10 finished products. Coenzyme Q10 Raw Materials [silica gel column] → [acetone, anhydrous ethanol] Coenzyme Q10 Raw Materials finished product
3. Method III. Beef heart dregs as raw material Beef heart dregs [10% NaOH-80% ethanol] → brownish-black solution [extraction] → gasoline extract [washing] → butter layer orange [concentration] → Coenzyme Q10 crude product [lipid precipitation] → clear oil layer [column chromatography] → Coenzyme Q10 eluent [freezing, concentration] → orange-yellow oily material [crystallization and drying] → Coenzyme Q10 CAS 303- 98-0Finished product