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Amphotericin B powder Raw Materials CAS 1397-89-3
Product Overview:
Amphotericin B powder, also known as Lushanomycin, is a polyene antifungal antibiotic isolated from Streptomycesnodosus culture solution. Amphotericin B is yellow or orange-yellow powder, odorless or almost odorless, tasteless. It has wettability and is easy to be destroyed and fail in sunlight. It gradually decomposes above 170℃ and is unstable at 37℃. . It is dissolved in dimethyl sulfoxide, slightly dissolved in dimethylformamide, very slightly dissolved in methanol, and insoluble in water, anhydrous ethanol, chloroform, or ether. Amphotericin B has a strong inhibitory or killing effect on a variety of fungal infections, such as cryptococcus neoformans, Candida albicans, histoplasma capsulatus, odontococcus dermatitis, Sporotrichia Schenckii, mucor and coccidioides. Amphotericin B powder is mainly used as the drug of choice for deep fungal diseases.
Amphotericin B powder Raw Materials CAS 1397-89-3 Attributes
Amphotericin B powder Raw Materials
CAS:1397-89-3
MF:C47H73NO17
MW:924.08
EINECS:215-742-2
Specification:99% min Amphotericin B powder
Sample:Amphotericin B powder Avaliable
Keywords:amphotericin B dosage
Appearance:white powder
Storage: Cool Dry Place
Brand: Ausreson
Shelf Life: 2 Years
Test Method: HPLC
Amphotericin B powder Raw Materials CAS 1397-89-3 Details
Uses and synthesis of Amphotericin B powder
Amphotericin B powder, also known as Lushanomycin, is a polyene antifungal antibiotic isolated from Streptomycesnodosus culture solution. Amphotericin B is yellow or orange-yellow powder, odorless or almost odorless, tasteless. It has wettability and is easy to be destroyed and fail in sunlight. It gradually decomposes above 170℃ and is unstable at 37℃. . It is dissolved in dimethyl sulfoxide, slightly dissolved in dimethylformamide, very slightly dissolved in methanol, and insoluble in water, anhydrous ethanol, chloroform, or ether. Amphotericin B has a strong inhibitory or killing effect on a variety of fungal infections, such as cryptococcus neoformans, Candida albicans, histoplasma capsulatus, odontococcus dermatitis, Sporotrichia Schenckii, mucor and coccidioides. Amphotericin B powder is mainly used as the drug of choice for deep fungal diseases.
| Formulation | Standard Dose | Max Daily Dose | Infusion Time |
|---|---|---|---|
| Conventional | 0.3-1.5 mg/kg | 1.5 mg/kg | 2-6 hours |
| Liposomal | 3-5 mg/kg | 10 mg/kg | 2 hours |
| ABLC | 5 mg/kg | 5 mg/kg | 2 hours |
Applications/Functions of Amphotericin B powder
- Amphotericin B powder has a strong inhibitory or killing effect on a variety of fungal infections, such as cryptococcus neoformans, Candida albicans, histoplasma capsulatus, odontococcus dermatitis, Sporotrichothrix Schenckii, mucor and coccidioides pachycoccidioides. Amphotericin B is the drug of choice for deep fungal diseases.
- Amphotericin B is a polyene antifungal drug. This product combines with sterols on fungal cell membrane, damages membrane permeability, leads to leakage of potassium ions, nucleotides, amino acids, etc. in bacterial cells, destroys normal metabolism and plays a antibacterial role.
amphotericin vs fluconazole.
| Amphotericin B | Fluconazole |
|---|---|
| - Nephrotoxicity (↓GFR, electrolyte imbalances like hypokalemia, hypomagnesemia) | - Generally well-tolerated |
| - Infusion reactions (fever, chills, hypotension) | - Hepatotoxicity (rare, but monitor LFTs) |
| - Anemia (suppresses erythropoietin) | - QT prolongation (risk with high doses or drug interactions) |
| - Lipid formulations reduce toxicity but are expensive | - Drug interactions (CYP450 inhibitor: affects warfarin, sulfonylureas, phenytoin, etc.) |
When to Choose Which?
-
Amphotericin B:
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Critically ill patient with suspected broad fungal infection.
-
Mucormycosis, resistant Candida, or Aspergillus.
-
-
Fluconazole:
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Stable patient with susceptible Candida or cryptococcal infection.
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Step-down therapy after amphotericin B induction.
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Physicochemical Property of Amphotericin B powder
Pale yellow to orange-yellow acicular crystal or powder. Insoluble in water, ethanol, soluble in acidic DMF, DMSO, slightly soluble in DMF, acidic or alkaline water-containing low alcohols. Odorless, almost tasteless. Easily destroyed by light, heat and acid.
FAQ.
Q: Why is it called "amphotericin"?
A: Due to amphoteric properties - soluble in both acid and base conditions
Q: How long is typical treatment?
A: 2-6 weeks depending on infection, sometimes months for cryptococcal meningitis
Q: Can side effects be prevented?
A: Pre-meds and hydration reduce but don't eliminate reactions
Q: Why choose liposomal form?
A: Fewer kidney effects but 20-50x more expensive
Q: Any new alternatives?
A: Echinocandins (caspofungin) for some infections, but AmB remains gold standard
Production methodprocess of Amphotericin B powder
Using Streptomyces nobilis strain as a strain, the aerated deep fermentation was carried out in liquid medium containing carbohydrate and organic nitrogen source, and amphotericin was extracted from the fermentation liquid when the equivalent titer unit was reached. Amphotericin contains two components, A and B. Component A has low toxicity and weak anti-fungal effect, and is not used in clinical practice, while component B has a strong effect, which is called Amphotericin B powder.
