Amphotericin B powder Raw Materials CAS 1397-89-3

MF:C47H73NO17

MW:924.08

EINECS:215-742-2

Specification:Amphotericin B powder

Sample:Amphotericin B powder

Brand:Amphotericin B powder

Appearance: powder

Storage: Cool Dry Place

Brand: chemical Raw Materials

Shelf Life: 2 Years

Test Method: HPLC

Uses and synthesis of Amphotericin B powder

Amphotericin B powder, also known as Lushanomycin, is a polyene antifungal antibiotic isolated from Streptomycesnodosus culture solution. Amphotericin B is yellow or orange-yellow powder, odorless or almost odorless, tasteless. It has wettability and is easy to be destroyed and fail in sunlight. It gradually decomposes above 170℃ and is unstable at 37℃. . It is dissolved in dimethyl sulfoxide, slightly dissolved in dimethylformamide, very slightly dissolved in methanol, and insoluble in water, anhydrous ethanol, chloroform, or ether. Amphotericin B has a strong inhibitory or killing effect on a variety of fungal infections, such as cryptococcus neoformans, Candida albicans, histoplasma capsulatus, odontococcus dermatitis, Sporotrichia Schenckii, mucor and coccidioides. Amphotericin B powder is mainly used as the drug of choice for deep fungal diseases.

Applications/Functions of Amphotericin B powder

1. Amphotericin B powder has a strong inhibitory or killing effect on a variety of fungal infections, such as cryptococcus neoformans, Candida albicans, histoplasma capsulatus, odontococcus dermatitis, Sporotrichothrix Schenckii, mucor and coccidioides pachycoccidioides. Amphotericin B is the drug of choice for deep fungal diseases.
2. Amphotericin B is a polyene antifungal drug. This product combines with sterols on fungal cell membrane, damages membrane permeability, leads to leakage of potassium ions, nucleotides, amino acids, etc. in bacterial cells, destroys normal metabolism and plays a antibacterial role.

Physicochemical Property of Amphotericin B powder

Pale yellow to orange-yellow acicular crystal or powder. Insoluble in water, ethanol, soluble in acidic DMF, DMSO, slightly soluble in DMF, acidic or alkaline water-containing low alcohols. Odorless, almost tasteless. Easily destroyed by light, heat and acid.

Production methodprocess of Amphotericin B powder

Using Streptomyces nobilis strain as a strain, the aerated deep fermentation was carried out in liquid medium containing carbohydrate and organic nitrogen source, and amphotericin was extracted from the fermentation liquid when the equivalent titer unit was reached. Amphotericin contains two components, A and B. Component A has low toxicity and weak anti-fungal effect, and is not used in clinical practice, while component B has a strong effect, which is called Amphotericin B powder.