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Uses and synthesis of Coenzyme Q10 powderCoenzyme Q10 powder is a small molecule fat-soluble quinone organic compound widely found in plant and animal cells. Its structure is similar to the structure of vitamin K, and it is a strong antioxidant when used alone or in combination with vitamin E. Coenzyme Q10 is required to drive the body's energy production (ATP) cycle. It can promote oxidative phosphorylation and protect the structural integrity of biofilm. Coenzyme Q10 exists in every cell in the human body, and its main role is to drive human cells to produce energy. It can accelerate cell renewal and stimulate cell activity, thus greatly promoting the ability of cells to take up nutrients.
Applications/Functions of Coenzyme Q10 powder
Coenzyme Q10 powder can be used as endogenous cellular antioxidant. Yes; An important part of the electron transfer chain. It is also a coenzyme drug used in the adjuvant treatment of congestive heart failure, arrhythmia, sinus tachycardia, premature beat, hypertension and cancer; Coenzyme Q10 can activate the body's cells and cellular energy nutrients, with the ability to improve human immunity, enhance antioxidant, delay aging and enhance human vitality. Coenzyme Q10 also has anti-tumor effects and has certain clinical efficacy for advanced metastatic cancer, preventing coronary heart disease, alleviating periodontitis, treating duodenal ulcer and gastric ulcer, enhancing human immune function and relieving angina pectoris. Widely used in medicine, cosmetics, food additives and other industries.
Pharmacological Action of Coenzyme Q10 powder
1. It can reduce the weakening of myocardial contractility and the reduction of creatine phosphate and adenosine triphosphate content during acute ischemia, maintain the morphological structure of ischemic myocardial cell mitochondria, and have a certain protective effect on ischemic myocardium.
2. It increases cardiac output and reduces peripheral resistance, which is beneficial to anti-heart failure treatment. It may inhibit the synthesis and secretion of aldosterone and block its effect on renal tubules.
3. When the isolated ventricular muscle of animals is perfused under hypoxic conditions, the duration of action potential can be shortened, and the threshold for ventricular arrhythmia is higher than that of control animals.
4. It can reduce peripheral vascular resistance and has an anti-aldosterone effect.
5. Coenzyme Q10 has anti-doxorubicin cardiotoxicity and liver protection effects.
Product method of Coenzyme Q10 powder
Preparation of crude coenzyme Q10 Take pig heart residue, add 1.5 times the amount of V ethanol: V ether = 3:1 mixed solvent, heat and extract 3-4 times, each time for 15-20 minutes, cool to room temperature, filter, and combine the extracts. Concentrate, add appropriate amount of water, add petroleum ether to extract, concentrate the extract, and the concentrate is a yellow oily substance, which is the crude coenzyme Q10 product.
Preparation of finished coenzyme Q10 Take crude coenzyme Q10, add acetone to dissolve, place below -10℃ to precipitate impurities, filter, evaporate the acetone from the filtrate, add a small amount of petroleum ether to dissolve, separate by silica gel column chromatography, add anhydrous ethanol to crystallize, and obtain the finished coenzyme Q10 product. Coenzyme Q10 crude product [silica gel column] → [acetone, anhydrous ethanol] Coenzyme Q10 finished product
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