Factory Supply 3-Methylpyridine Powder CAS 108-99-6 Raw Materials
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3-Methylpyridine Powder Usage and Synthesis.
3-Methylpyridine CAS 108-99-6, also known as β-methylpyridine, is an organic compound with the chemical formula C6H7N, a colorless or yellow liquid, soluble in water, soluble in ethanol, ether and most other organic solvents, mainly used as a solvent, also used in the preparation of nicotine and nicotinamide.
3-Methylpyridine CAS 108-99-6 is a homologue of pyridine, which is an aromatic hydrocarbon and a six-membered ring, similar to benzene in some aspects, but different from benzene, for example, toluene has no isomers, while methylpyridine has three isomers, namely 2-methylpyridine, 3-methylpyridine and 4-methylpyridine with a relative molecular mass of 93.13.
3-Methylpyridine CAS 108-99-6 is naturally present in coal tar and is chemically active, and can undergo side chain oxidation and nitrogen substitution, or condensation with aldehydes and ketones catalyzed by alkali.
Also known as α-methylpyridine, α-picoline. Colorless liquid. Has a strong irritating odor. Relative density 0.9462. melting point -66.8℃. Boiling point 128.8℃. Refractive index 1.4957. Flash point 26℃. Soluble in water and acetone, miscible with ethanol and ether. Azeotropic mixture with water, 52% of this product, azeotropic point 93.5℃. Oral LD501410 mg/kg in rats.
Application/Function of 3-Methylpyridine Powder
3-Methylpyridine Raw Materials is used to make 2-Vinyl pyridine, pharmaceuticals, dyes, fertilizer synergists, herbicides, veterinary drugs, rubber accelerators.
- Uses: raw materials for the production of 2-methylpyridine; raw materials for pesticide, production of "azoxystrobin", "pyridine-2,5-dicarboxylic acid ester", "chlormequat chloride", "clorodin", "clorodin", "Cloridine", "Dioxopicolinic acid", "Methyl iodide 2-pyridyl aldoxime", "Picloram", etc. 3-Methylpyridine Raw Materials is also known as β-methylpyridine, β-picoline. Colorless transparent liquid. Has a pungent odor. Taste slightly sweet. Relative density 0.9560, 0.9613(15℃). Melting point -18.3℃. Boiling point 143.9℃. Refractive index 1.5403. Flash point 36℃(closed). Miscible with water, ethanol and ether. It forms an azeotropic mixture with water, the content of this product is 27%, the azeotropic point is 96.7℃. This product is different from [1] and [3], its methyl reactivity is poor. It is irritating to the skin and can also be absorbed percutaneously. Its vapor irritates the eyes and respiratory tract, causing inflammation and, in severe cases, blisters, vomiting, headache and other symptoms. Oral LD50790mg/kg in rats.
- Uses: Pesticide raw materials, the production of herbicides, insecticides, fungicides, such as "procyanidin", "phenylpyrrol" and rodenticide "anti-rodent"; food additives, meat products processing It can be added to bread, pastry, rice products, dairy products, ham and sausage, etc., to strengthen the role of vitamin medicine, and can be used instead of vitamin B; as a vitamin fortification agent can be added to infant milk powder, women's expectant milk powder, food and drinks; also used as medicine, for the treatment of niacin deficiency; feed It can also be used as medicine for the treatment of niacin deficiency; feed additive; production of niacinamide or substitute for niacinamide; alcohol modifier; dye intermediate; rubber vulcanizing agent and film sensitizer raw material, etc.3-Methylpyridine Raw Materials is also known as γ-methylpyridine, γ-picoline. Colorless liquid. Flammable. Unpleasant odor. Sweet taste. If mixed with impurities, the color gradually becomes yellow. Relative density 0.9558. Melting point 3.7℃. Boiling point 144.9℃. Refractive index 1.5064(17℃). Flash point 56℃. Soluble in water, ethanol and ether. The product forms azeotropic mixture with water, the content of this product is 63.5%, the azeotropic point is 97.4℃. It is irritating to skin, eyes and mucous membranes, and can be felt even at a concentration of 1×10-6 due to a foul odor, which can be prevented early. After poisoning, nausea, vomiting, headache, and in serious cases, it can cause internal organs and nerve center disease. Oral LD501290mg/kg in rats.
- Uses: Medicine raw material, production of tuberculosis treatment "isoniazid", antidepressant "niacinamide", antidote "double compound phosphorus"; pesticide raw material, production of insecticides and herbicides; also It can be used in dyestuff, rubber auxiliary, fabric water repellent, resin curing agent; it is the raw material of nicotinaldehyde, 2-amino-4-methylpyridine (veterinary medicine), pyridine-4-carboxylic acid (anti-coagulant), etc.
- 3-Methylpyridine Raw Materials is used in pharmaceutical industry, also used as dye intermediates, resin intermediates, insecticides and water repellents, etc.
- 3-Methylpyridine Powder, also known as β-methylpyridine, 3-picoline, is an organic synthesis intermediate and solvent, used as an intermediate of insecticide imidacloprid and acetamiprid in pesticide, used in the synthesis of the next intermediate 3-methylpyridine-N-oxide, also used as pharmaceutical intermediates, dye intermediates, resin intermediates, etc.
- 3-Methylpyridine Raw Materials are mainly used in the manufacture of vitamin B6, nicotinic acid and nicotinamide, nicotinamide and cardiac stimulants and other drugs; also used as solvents, alcohol denaturant, dye intermediates, resin intermediates, rubber vulcanization accelerator, insecticide, water repellent raw materials, and film sensitizer additive.
- 3-Methylpyridine Powder is mainly used in the manufacture of vitamin B, nicotinic acid, cardiotonic agent, etc. It can also be used as solvent, alcohol denaturant, various intermediates, insecticide.
Property and Stability of 3-Methylpyridine Powder
- Chemical property is similar to pyridine, it is alkaline and can generate salt with inorganic acid and organic acid. It can form addition compounds with inorganic salts and halogenated alkanes. When hydrogenated, it can produce 3-methylpiperidine or pyridine depending on the reaction conditions. When oxidized, it produces pyridine-3-carboxylic acid (nicotinic acid, C5H4N-CO2H) or pyridine.
- Health hazard Invasion route: inhalation, ingestion, transdermal absorption. Health hazard: Exposure to this product may cause fatigue, general weakness, drowsiness, etc. In severe cases, neurological symptoms, such as unsteady gait, transient loss of consciousness, etc. Toxicological information and environmental behavior Toxicity: It is a low toxicity category. Acute toxicity: LD50400～800mg/kg (rat orally); LD50800～1600mg/kg (mouse orally). Hazardous characteristics: Flammable, in contact with high heat, open flame or oxidizer, there is a risk of combustion and explosion. Decomposition by heat emits toxic nitrogen oxide fumes. Combustion (decomposition) products: carbon monoxide, carbon dioxide nitrogen oxide. Protective measures Respiratory protection: A filtered gas mask (half mask) should be worn when exposure to its vapors is possible. If necessary, an air respirator is recommended. Eye protection: Wear chemical safety glasses Body protection: Wear toxic permeation resistant overalls. Hand protection: Wear rubber gloves. Other: Smoking is strictly prohibited at the work site. After work, shower and change clothes. Pay attention to personal cleanliness and hygiene.
- Stability: stable
- Prohibited substances: acid, acyl chloride, strong oxidizer, chloroform
- Avoid contact conditions: heat
- Polymerization hazard: No polymerization
Production method of 3-Methylpyridine Powder
3-Methylpyridine Powder should be stored in a cool, ventilated room. Keep away from fire and heat source. Storage temperature should not exceed 37℃. Keep the container sealed. Store separately from oxidizers and acids, and do not mix them. Use explosion-proof lighting and ventilation facilities. Prohibit the use of spark-prone machinery and tools. The storage area should be equipped with leakage emergency treatment equipment and suitable shelter materials.
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