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Uses and synthesis of Vitamin B12 Powder

Vitamin B12 CAS 68-19-9 is abbreviated as VB12, also known as cobalamin, one of the B vitamins, is a class of cobalt-containing cobalt complex organic compounds, containing trivalent cobalt is located in the center of the porphyrin-like cobalt ring plane. It is the largest and most complex vitamin molecule that has been discovered, and is the only vitamin that contains metal ions; its crystallization is red, so it is also known as the red vitamin. Plants do not contain VB12 and cannot manufacture Vitamin B12 CAS 68-19-9

Liver is the best source of VB12, followed by milk, meat, eggs, fish, etc. VB12 is an essential coenzyme in the synthesis of ribonucleic acid and deoxyribonucleic acid, and a deficiency of Vitamin B12 Powder in the body can cause pathologic changes in the nervous system, such as peripheral and central encephalopathy. The prototypes of the family of naturally occurring cobalt-ligand compounds are called corrinoids.The analogs of Vitamin B12 Raw Materials differ only in the beta ligand of cobalt and are called cobalamin.

Vitamin B12 Raw Materials Western drug name. Common dosage forms include injections, tablets, and eye drops. Vitamin B12 Raw Materials. Used in megaloblastic anemia; also used as adjunctive therapy for subacute combined degenerative neurologic lesions such as neuritis.

Applications / Functions of Vitamin B12 Powder

Vitamin B12 Raw MaterialsThe prototype of the naturally occurring family of cobalt coordination compounds is called cobaltoid. The analogs of vitamin B12 differ only in the beta-ligand of cobalt and are called cobalamin. It is synthesized almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamin. The body converts them to biologically active forms, methylcobalamin and cobalamin, which act as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological dysfunction.

• 1.Vitamin B12 Powder medical and health care applications are mainly used in the treatment of various VB12 deficiencies, such as: can treat megaloblastic anemia, anemia caused by drug poisoning, aplastic anemia and leukopenia, etc.; with pantothenic acid, it can prevent pernicious anemia, help the absorption of Fe2+ and the secretion of gastric acid; it is also used to treat arthritis VB12 has also been used in the treatment of arthritis, facial nerve palsy, trigeminal neuralgia, hepatitis, herpes, asthma and other allergies, atopic dermatitis, measles, eczema, and bursitis; VB12 can also be used in the treatment of nervousness, irritability, insomnia, memory loss, and depression. New research shows that VB12 deficiency can also cause depression and other mental illnesses. Vitamin B12 Powder as a therapeutic agent or health care products is very safe, more than thousands of times the RDA Vitamin B12 Raw Materials were injected intravenously or intramuscularly no toxicity has been found.
• 2.Vitamin B12 Raw Materials in the application of feed VB12 can promote the growth and development of poultry, livestock, especially young birds, young animals to improve the utilization rate of feed protein, which can be used as feed additives. The treatment of fish eggs or fry with VB12 aqueous solution can improve the tolerance of fish to toxic substances in water, such as benzene and heavy metals, and reduce the mortality rate. Since the "mad cow disease" incident in Europe, the use of vitamins and other chemical structure of the clear nutritional supplements to replace the "meat and bone meal" has a greater space for development. At present, most of the Vitamin B12 CAS 68-19-9 produced in the world is used in the feed industry.
• 3.Vitamin B12 CAS 68-19-9 in other applications in developed countries, VB12 and other substances used in cosmetics; in the food industry, VB12 can be used as ham, sausage, ice cream, fish sauce and other food coloring agent. In family life, Vitamin B12 Powder solution adsorbed on activated carbon, zeolite, non-woven fiber or paper, or made into soap, toothpaste, etc.; can be used for toilets, refrigerators, etc., anti-odor, to eliminate the smell of sulfide and aldehyde; Vitamin B12 CAS 68-19-9 can be used for environmental protection of common pollutants in the soil and surface water - the dehalogenation of organohalogenides.

Vitamin B12 Powder deficiency can lead to anemia and neurological disorders. It can be used in infant food at a dosage of 10-30 μg/kg and in fortified drinks at a dosage of 2-6 μg/kg.

Vitamin B12 Powder is mainly used for the treatment of megaloblastic anemia, malnutrition, hemorrhagic anemia, neuralgia and disorders.

Vitamin B12 CAS 68-19-9 is used as feed nutrient fortifier, with anti-anemia effect, it is effective for pernicious anemia, nutritional anemia, parasitic anemia with dosage of 15-30mg/t.

Vitamin B12 Raw Materials is an essential vitamin in the process of human tissue metabolism. The average total amount of vitamin B12 in the human body is 2-5mg, of which 50-90% is stored in the liver and released into the blood to form red blood cells when needed by the body. Long-term lack of B12 will lead to pernicious anemia. B12 and folic acid is an important enzyme in the process of cellular synthesis of nucleic acids, involved in the synthesis of purines, pyrimidines, nucleic acids, and methionine, etc.; and can make methyl transfer, and promote the synthesis of butane; and at the same time increase the synthesis of sugar metabolism, thus having the role of eliminating liver fat. Clinically, it is often used as a drug for the treatment of liver disease. The human body needs about 211 micrograms of vitamin B per day, and 2 micrograms of vitamin B12 can be provided in food every day to ensure the normal needs. Hydroxocobalamin in Vitamin B12 can react with cyanide to produce cyanocobaltic acid, which can eliminate the toxicity of cyanide. Therefore, Vitamin B12 Raw Materials deficient people are more sensitive to cyanide than the general population.Vitamin B12 Raw Materials is mainly used in the treatment of pernicious anemia, megaloblastic anemia, anemia initiated by antifolic acid drugs and polyneuritis.

Vitamin B12 Powder properties and stability

Vitamin B12 Powder is a deep red crystalline or amorphous crystalline powder, odorless and tasteless. Melting point 210～220°C (carbonization black).1g of this product can be dissolved in 80mL water, soluble in ethanol, insoluble in acetone, ether or chloroform. Anhydrous material is easy to absorb moisture, crystalline cyanocobalamin in neutral and slightly acidic solution, air and heat stability is good, in alkaline, strong acid and reducing agent is less stable, intolerance of light and ultraviolet light.

Production method of Vitamin B12 Powder

Vitamin B12 Powder can be synthesized in large quantities by actinomycetes such as Streptomyces griseus, and the cultures of such bacteria are used industrially to produce Vitamin B12. The total synthesis of Vitamin B12 Raw Materials was accomplished by R.B. Woodward in 1973, which was a very prominent work in organic synthesis.

1. (1) Prepared by fermentation of Streptomyces griseus, the fermentation broth was acidified and adsorbed with a weakly acidic acrylic acid-based cation exchange resin - 122, then eluted, purified, converted with 1% cyanide, and the finished product was obtained by repeated extraction with solvent and water, lead oxide chromatography, and acetone crystallization.
2. (2) glucose sugar, corn syrup as raw materials, inoculated with Propionibacterium shermarii (Propionibacterium shermarii) fermentation, to the fermentation broth, add cobalt chloride, 5,6-2 methylbenzimidazole, after extraction and drying to obtain the product

Prepared by the fermentation of Streptomyces griseus, the fermentation broth was acidified and adsorbed with weakly acidic acrylic acid system cation exchange resin-122, then eluted, purified, transformed with 1% cyanide, and the finished product was obtained by repeated extraction, concentration, lead oxide chromatography, and acetone crystallization by solvent and water.ChemicalbookTaking glucose and corn syrup as the Raw material, inoculated with Propionibacteriumshermarii fermentation; add cobalt chloride, 5,6-dimethylbenzimidazole to the fermentation broth, extracted and dried to obtain the product.

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