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Uses and synthesis of Inosine Powder

Inosine Powder, also known as hypoxanthine, hypoxanthine nucleoside, etc., the properties of white needle-like crystals, odorless, slightly bitter taste.Inosine Powder is a nucleoside analog from the combination of hypoxanthine and ribose. Inosine Powder is a nucleoside compound formed by combining hypoxanthine with ribose. In the de novo synthesis of purine (denovosynthesis), Inosine Powder can be used as a precursor for the synthesis of adenosine monophosphate (AMP) and guanosine monophosphate (GMP). The melting point is 218 degree C. 1.6g of the product is dissolved in 100ml of water at 20 degree C. The product can be used as a precursor for the synthesis of AMP and GMP.

Inosine CAS 58-63-9 is also known as hypoxanthine, hypoxanthine nucleoside and so on. It is a nucleoside compound which is formed by the combination of hypoxanthine in ribose. In the de novo synthesis of purines, inosine (IMP) can be used as a precursor for the synthesis of adenosine monophosphate (AMP) and guanosine monophosphate (GMP).

Inosine CAS 58-63-9 is used in the treatment of leukopenia, thrombocytopenia, cardiac diseases, acute and chronic hepatitis, cirrhosis, etc. It can also be used in the treatment of central retinitis, optic nerve atrophy.

Inosine Raw Materials The name of a western medicine. Common dosage forms include oral solution, tablets, capsules, and injections. Inosine Raw Materials is used for the treatment of leukopenia or thrombocytopenia, various acute and chronic liver diseases, pulmonary heart disease and other heart diseases; central retinitis, optic atrophy and other diseases. The type of medical insurance for this product is: Inosine Powder oral solution for non-medical insurance, injectable inosine, inosine tablets, inosine injection, inosine capsules for medical insurance A class.

Applications / Functions of Inosine Powder

Inosine Powder Oral Solution is mainly used for the adjuvant treatment of acute and chronic hepatitis. Mild and moderate chronic hepatitis: The early symptoms of typical chronic hepatitis are mild and lack specificity, fluctuating and intermittent, or even years without any symptoms. The most common are easy fatigue and stomach discomfort, which can be easily ignored and mistaken for stomach disease; patients with insidious cirrhosis are often seen in the clinic, who do not feel any obvious discomfort before the appearance of cirrhosis and do not undergo routine physical examination, and gradually develop into cirrhosis unknowingly; occasional patients with nausea, abdominal distension, jaundice, and dark urine, but based on the symptoms, they cannot determine the chronic hepatitis However, the severity of chronic hepatitis cannot be judged based on the symptoms.

1. Inosine Powder is involved in energy metabolism and protein synthesis in the body. It can be used to treat leukopenia and thrombocytopenia due to various reasons. It can cause mild diarrhea, and cannot be combined with lactic acid, chloramphenicol, pansentin and sodium thiopental injection.
2. Inosine CAS 58-63-9 is used as coenzyme drugs.
3. Inosine Raw MaterialsBiochemical studies. Pharmaceutically used to promote white blood cell growth
4. Inosine Raw Materials is a potential stimulator of nerve production factor (NGF).
5. Inosine CAS 58-63-9 almost no toxicity and side effects, can directly through the cell membrane into the body cells, so that the cells in the human low-energy, hypoxic state can continue to carry out the metabolism smoothly, and can activate the pyruvate oxidase class, participate in the body's protein synthesis. It is mainly used for various types of liver disease, heart disease, leukopenia, thrombocytopenia, central retinitis, as well as preventing and relieving the side effects caused by antimony.

Inosine Powder properties and stability

Inosine Raw Materials is white crystalline powder; odorless; slightly bitter taste. Slightly soluble in water, insoluble in chloroform, ethanol, soluble in dilute hydrochloric acid or sodium hydroxide and other alkali solutions.The saturated aqueous solution of Inosine Powder contains about 1.5% of inosine. mp218°C (decomposition).

Inosine CAS 58-63-9 is white crystalline powder; odorless; slightly bitter taste. Insoluble in chloroform, ethanol, soluble in dilute hydrochloric acid or alkali hydroxide solution.Saturated aqueous solution of Inosine CAS 58-63-9 contains about 1. 5% inosine. Melting point 218°C (decomposition).

Inosine Powder is a normal component of human body, it is the intermediate product of nucleotide metabolism in the body, under the action of relevant enzymes, it can form hypoxanthine nucleoside, and further converted to adenine nucleotide or guanine nucleotide, thus also provide raw material for ATP synthesis.Inosine Powder can directly enter into the cell, participate in glucose metabolism, improve the activity of coenzyme A and activate the pyruvate oxidase, make the inosine inactive in the cell. Inosine Powder can directly enter into the cell, participate in glucose metabolism, increase the activity of coenzyme A and activate pyruvate oxidase, so that the cells in a state of low energy and hypoxia can continue to metabolize smoothly, which can help to restore the function of damaged liver cells..

Production method of Inosine Powder

Inosine Powder can be produced by direct fermentation or semi-synthetic method. Semi-synthetic method uses fermented disodium inosinate as raw material, and then dephosphorylates to obtain inosine.

Inosine dephosphorylation method of disodium inosinate preparation Rodobacterium 269 fermentation, fermentation broth to remove the bacterium, adsorption, elution, concentration, addition of ethanol, pH 7-7.5 conditions of crystallization can be obtained inosine disodium inosinate. Rod-shaped bacillus 269 [fermentation] → fermentation broth [depyrogenation, adsorption, elution, concentration] → concentrate [ethanol] → [pH 7-7.5] disodium inosinate Inosine crude preparation in acetic acid buffer, adjust pH 5.4-5.6, pressurized 137-147kPa, dephosphorylated for 5h, inosine can be obtained as a crude product. Disodium inosinate [acetic acid, pressurized] → Inosine refined distilled water dissolution, pH = 6, recrystallization, can get Inosine Raw Materials

• (1)Fermentation of Corynebacterium fermentation to produce inosinic acid, and then chemically remove the phosphoric acid to obtain Inosine CAS 58-63-9.
• (2)Inosine Powder was prepared by one-step fermentation with adenine and thiamine double nutrient-deficient Bacillus mutans strain.

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