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Uses and synthesis of Thioctic Acid Powder

Thioctic Acid Powder is a unique anti-free radical substance often referred to as a broad spectrum antioxidant. It is a vitamin-like substance produced in the body.Unlike other antioxidants produced in the body that have specific effects, Thioctic Acid Raw Materials is neither strictly fat-soluble nor water-soluble, which allows it to contribute to the activity of other antioxidants in the body, and is a widely available alternative to antioxidants when they are insufficient. It is also a widely available alternative when antioxidants are insufficient.

For example, if the body's stores of vitamin c and vitamin E are low, Thioctic Acid CAS 1077-28-7 can be temporarily replenished. Because DL-lipoic acid can cross the blood-brain barrier, it can help reverse the adverse effects caused by strokes.Thioctic Acid CAS 1077-28-7 also helps to maintain normal blood glucose levels and prevent serious complications of diabetes. As we age, the body will not be able to make enough DL-Lipoic Acid to maintain good health. If you are already in your forties. Then don't miss the opportunity to supplement with DL-Lipoic Acid. Commercially available DL-Lipoic Acid is available as tablets or as an antioxidant formulated product containing DL-Lipoic Acid. It is recommended to take one to two 50mg tablets of DL-Lipoic Acid daily.

Thioctic Acid CAS 1077-28-7 is a pale yellow powdery crystal, almost odorless, with a low solubility in water of about 1 g/L (20°C). Soluble in 10% NaOH solution, soluble in aliphatic solvents.Thioctic Acid Powder is soluble in methanol, ethanol, chloroform, ether.

Thioctic Acid Powder is also known as α-lipoic acid.

Thioctic Acid Raw Materials has a chiral center and therefore has both R and S configurations.

Natural Thioctic Acid Raw Materials are white crystals with only the R configuration, and only R-configured lipoic acid can covalently bond to lysine residues via amide bonds to function as a coenzyme.

Synthetic lipoic acid is a mixture of equal proportions of R- and S-configurations, and is a yellowish powder that is highly soluble in lipid-based solvents.

Applications / Functions of Thioctic Acid Powder

Thioctic Acid Raw Materials is also a highly effective antioxidant, which plays an important role in the prevention and treatment of many diseases.

Thioctic Acid Raw Materials In the pharmaceutical field, alpha lipoic acid is widely used in the prevention and adjuvant treatment of diabetes mellitus and its related complications.Thioctic Acid Powder can enhance glucose metabolism, attenuate oxidative stress, alleviate the symptoms of diabetic neuropathy, prevent diabetic cataracts, and prevent diabetic cardiovascular damage.

Thioctic Acid Powder Vitamins that stimulate fat metabolism.Thioctic Acid CAS 1077-28-7 is used in the treatment of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes, and other diseases and therapeutic healthcare

Antioxidant and as a coenzyme of e.g. pyruvatedehydrogenase and glycine decarboxylase, exogenous lipoic acid is reduced by two or more enzymes within the cell. This reduced form affects the cellular process of free radical scavenging. Increases glutathione (glutathione) synthesis and regulates transcription factor activity. Decreased phagocytosis of macrophage myelin.

Thioctic Acid Powder properties and stability

The appearance of Thioctic Acid CAS 1077-28-7 is light yellow powdery crystal, almost odorless, the chemical structure is 6,8 a DL-lipoic acid, in the 6,8 carbon between the disulfide bond connected to form an endodisulfide compound, when returned to the original Chemicalbook, the disulfide bond breaks to form dihydro DL-lipoic acid. When being reduced original, disulfide bond broken to form dihydro DL-lipoic acid. α-Lipoic acid is insoluble in water but soluble in fat solvents, some people listed as fat-soluble vitamins; soluble in methanol, ethanol, chloroform, ether.

Thioctic Acid CAS 1077-28-7 is a water-soluble and fat-soluble metabolic antioxidant that is a vitamin-like substance. Dr. Lester Parker, a professor of molecular cell biology at the University of California, Berkeley, is one of the world's leading antioxidant researchers, and he calls α-lipoic acid a "super antioxidant," one of the "most versatile and active" of all antioxidants.

Helps patients reduce their dependence on insulin and hypoglycemic medications

1. Thioctic Acid Powder is the only fat-soluble and water-soluble universal antioxidant, and the effect of alpha lipoic acid is more durable than other antioxidants. Lipoic acid can balance blood sugar, promote glucose absorption, improve blood sugar control in diabetic patients, so that patients can reduce the use of insulin or hypoglycemic drugs.
2. Protect the nerve tissue of diabetic patients, help treat peripheral neuropathyForeign studies have proved that Thioctic Acid Powder can significantly improve the clinical symptoms caused by diabetic peripheral neuropathy, and has been recommended for the adjuvant treatment of diabetic peripheral neuropathy in Germany for more than 30 years.Thioctic Acid Powder can protect the nerve tissues of diabetic patients, and help to treat the inflammation due to the deposition of proteins in the nerve cells. Inflammation due to protein deposition in nerve cells.
3. Thioctic Acid Raw Materials is a super antioxidant.Thioctic Acid Raw Materials has 5-10 times the antioxidant capacity of grape seed, which in turn has 20 times the antioxidant capacity of vitamin C. It has 60 times the antioxidant capacity of vitamin E, and combines both vitamin C and vitamin E with antioxidants. Vitamin E 60 times, both fat-soluble and water-soluble properties, can be absorbed by all tissues and organs.

Production method of Thioctic Acid Powder

• (1) Take sodium sulfide in a beaker, add distilled water to the beaker, and heat and stir below 50°C to dissolve it to form a 3 mol/L sodium sulfide solution; add sulfur to the resulting sodium sulfide solution, and stir to dissolve it to make the concentration of sulfur in the sodium sulfide solution 3.5 mol/L, and obtain a mixed solution;
• (2) Add ethyl 6,8-dichlorooctanoate and distilled water sequentially to the photoreactor to formulate a 3 mol/L ethyl 6,8-dichlorooctanoate solution, and then add a phase transfer catalyst to the solution, and stir to raise the temperature to 82-84 °C;
• (3) The mixed solution obtained from step (1) was added dropwise to the reaction solution of step (2) at a volume ratio of 5:3.5 within 180 min, while a 1000 W xenon lamp was used and a cut-off filter of 680 nm was used for photocatalysis of the reaction solution, and the reaction solution was stirred at a speed of 200 r/min;
• (4) Sodium sulfite was added to the photoreactor after the cyclization reaction, such that the concentration of sodium sulfite in the reaction solution was 0.45 mol/L, and the reaction was carried out under photocatalysis at 86-90°C for 60 min.
• (5) After the reaction was completed, the reaction solution was extracted at 80 to 90°C. The organic layer was diluted with toluene while the aqueous layer was extracted with toluene, the toluene layers were combined, and then the toluene layer was rotary evaporated to a constant weight, to obtain ethyl thioctanoate; and then ethyl thioctanoate was hydrolyzed and acidified to obtain thioctic acid.

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