Factory Supply Glucosamine Powder CAS 3416-24-8 Raw Materials

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Uses and synthesis of Glucosamine Powder

Glucosamine, also known as Glucosamine, Glucosamine Powder, 2-Deoxy Glucosamine, is a common aminosugar and a derivative of glucose. It is a derivative of glucose. It is a compound made by replacing the hydroxyl group on the second carbon atom of the glucose molecule with an amino group. A hydrogen atom on the amino group is often replaced by an acetyl group to form N-acetylglucosamine. It rarely exists freely in living organisms and is mainly used as a component of chitin, glycoproteins and proteoglycans.

Glucosamine CAS 3416-24-8, Glucosamine Hydrochloride, or Glucosamine Sulfate, is the name of a western medicine. It is an anti-inflammatory and anti-rheumatic drug. Used for osteoarthritis in various parts of the body, such as knee, hip, and spine, wrist, hand, shoulder, and ankle, etc. Glucosamine Raw Materials, a compound in which one of the hydroxyl groups of glucose is replaced by an amino group. Molecular formula C6H13O5N, commonly known as aminosugar.

Glucosamine CAS 3416-24-8 is widely found in nature.2-Amino-2-deoxy-D-glucose is usually found in microorganisms, polysaccharides of animal origin, and bound polysaccharides, either as N-acetyl derivatives (e.g., chitosan) or in the form of N-sulphate esters and N-acetyl-3-O-lactate ethers (cytosolic acid).

Glucosamine Raw Materials are currently extracted from crustaceans such as shrimp and crab.

Applications / Functions of Glucosamine Powder

Glucosamine Powder is widely used in the production of health medicines, health foods, and beauty cosmetics. It has an important health care role in improving the life rate of human activities and promoting the growth of tissues that synthesize life substances in the human body.

1、Applicable Diseases：Degenerative Arthritis of Knee Joints

Mechanism of Glucosamine Raw Materials: Glucosamine Raw Materials treats knee arthritis mainly by repairing articular cartilage, catalyzing synovial fluid, so that there is no more hard friction between joint surfaces, and there is no more pain, swelling, bone friction sound and other symptoms, and through the repair of articular cartilage, it restores the joint gap to normal, and joint function is completely restored. Joint function is completely restored.

2、Adaptive disease: osteophytes

Glucosamine Powder mechanism: exogenous intake of glucosamine, so that the content of glucosamine in the joints to restore the balance of the state, stimulate chondrocytes to synthesize proteoglycans and collagen fibers, the generation of cartilage matrix, the repair of damaged cartilage, so that the articular cartilage itself to increase the ability to repair through the Glucosamine Powder to repair the articular cartilage, the generation of synovial fluid, and so that the joint function is completely restored. It plays a fundamental role in the treatment of osteoarthritis (osteoarthritis).

3、Applicable Diseases：Meniscus Injury

Glucosamine Powder's mechanism of action: Glucosamine Powder can repair the damaged meniscus, and at the same time, repair the cartilage damage on the joint surface secondary to meniscus injury, and repair the joint damage fundamentally. At the same time, Glucosamine Powder can remove harmful factors, inhibit and eliminate synovial inflammatory reaction.

4、Indications: patella, chondromalacia

Glucosamine CAS 3416-24-8 Mechanism of Action: Exogenous supplementation of Glucosamine CAS 3416-24-8 can repair the articular cartilage between patella and femur.

5, Adaptation disease: cervical spondylosis nerve root type

6. Adapted Diseases: Cervical spondylosis spinal cord type

7, Adaptation diseases: cervical spondylosis vertebral artery type

8、Indications for diseases: cervical spondylosis sympathetic type

Glucosamine CAS 3416-24-8 Mechanism of action: Glucosamine Powder inhibits the inflammatory reaction of intervertebral joint soft tissues, eliminates soft tissue edema, and repairs the broken cartilage ring, so that the herniated disc is not easy to break out, and promotes the normal secretion of synovial fluid, so as to make the neck movement more flexible.

9、Adaptive Disease：Synovitis

Glucosamine Powder Mechanism of Action: Glucosamine Raw Materials can remove harmful substances in the joint cavity and also repair the joint cartilage and diseased synovial membrane to alleviate pain, swelling and other symptoms.

10、Adaptive diseases: hand bone, arthritis

Glucosamine Raw Materials Sugar Mechanism: Supplementation of Glucosamine Raw Materials can repair worn out articular cartilage and reduce joint pain caused by worn out articular cartilage.

11、Adaptive disease: foot bone, arthritis

Glucosamine Raw Materials mechanism of action: after taking Glucosamine, Glucosamine can repair the wear and tear of articular cartilage, such as long-term use of the ankle joints of athletes who frequently engage in strenuous physical activity, has a very good protective effect.

12、Adaptive Diseases：Frozen shoulder

Glucosamine Powder Mechanism: Glucosamine can repair soft tissues such as tendon, ligament, synovium and bursa by promoting the synthesis of proteoglycans and collagen fibers, catalyzing the synovial fluid of joints and bursa, lifting the adhesion of joints and soft tissues, and restoring the activity function of shoulder joints.

13、Adaptive disease: lumbar intervertebral disc herniation

Glucosamine Raw Materials Mechanism: Supplementation of Glucosamine Powder can significantly improve the degradation of intervertebral articular cartilage and intervertebral disc fibrocartilage ring, reduce the pain of patients.

14、Adaptive Diseases：Rheumatism, arthritis

Mechanism of Glucosamine Powder: Rheumatoid arthritis will lead to the destruction of articular cartilage, supplementation of Glucosamine Raw Materials can repair the wear and tear of articular cartilage and reduce the pain of patients.

Glucosamine Powder properties and stability

Glucosamine Powder is white crystalline or crystalline powder.

Molecular formula C6H13NO5, molecular weight 179.17, Glucosamine has the nature of polyhydroxy amine, in the form of polymers or derivatives exist in crustaceans, insects, molds and bacteria in the cell wall. Chitosan (condensate of N-acetylamino glucose) is generated when water is aminoglucose. α-body is crystalline, melting point 88 ° C, in aqueous solution to change the spin [α] D20100 ° → 47.5 ° (30 minutes). β-body from methanol to get needle crystals, 110 ° C decomposition, in aqueous solution to change the spin [α] D2028 ° → 47.5 ° (30 minutes). Soluble in water, soluble in hot methanol, slightly soluble in cold methanol and ethanol, insoluble in ether and chloroform. Exists in chitosan, mucin, mucopolysaccharide. A trace organic component in seawater, particulate matter and marine sediments. The content in marine specimens can be determined photometrically after hydrolysis and cation exchange column separation. Preparation: Reaction of dehydrated glucose with ammonia in absolute anhydrous ethanol, followed by hydrolysis to produce glucosamine crude.

Pharmacologic action of Glucosamine Powder

• Amino eugenol is an amino monosaccharide present in the body, especially in the articular cartilage. It is an important component for the synthesis of proteoglycan in the matrix of human articular cartilage. It can selectively act on osteoarthritic joints, interrupt the pathological process of osteoarthritic joints, stimulate the cartilage to produce glycoproteins with normal multimeric structure, inhibit cartilage-donating enzymes such as collagenase and phosphoconjugate A, and control the production of superoxide gateway radicals in the injured cartilage, preventing the damage of corticosteroid and certain non-residual antisale drugs to the cartilage and alkaline endotoxin factors from releasing in the injured cartilage. The above mentioned pathways, this product has a direct effect on cartilage damage. Through the above pathway, this product has a direct effect on the pain of osteoarthritis, can alleviate the pain symptoms of osteoarthritis, improve the function of joints, and can be used to stop the development of osteoarthritis disease.
• Glucosamine Raw Materials is well tolerated, and the results of acute toxicity test show that the LD56 of mice given by mouth is more than 20g/kg, and the LD56 of mice given by intraperitoneal injection is more than 7.5g/kg.
• Osteoarthritis is a degenerative disease of articular cartilage caused by abnormal proteoglycan biosynthesis.
• Glucosamine Powder is a normal constituent of cartilage matrix polypolysaccharide chain and joint fluid polyglucosamine. In vivo and in vitro studies have shown that Glucosamine Sulfate can stimulate chondrocytes to synthesize physiological polyglucosamine and proteoglycans and synovial cells to synthesize hyaluronic acid. In addition, it inhibits the activity of enzymes that cause cartilage damage, such as collagenase and phospholipase A2, inhibits the production of certain tissue-damaging substances such as superoxide radicals, and inhibits the activity of lysosomal enzymes. It has shown mild anti-inflammatory effects in in vivo tests including several different types of arthritis models. Unlike NSAIDs, glucosamine sulfate does not inhibit prostaglandin synthesis.
• Safety tests have shown no effect on the cardiovascular system, respiratory system, central nervous system or autonomic nervous system.

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