Factory Supply Lipoic acid Powder CAS 62-46-4 Raw Materials

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Uses and synthesis of Lipoic acid Powder

Lipoic acid powder is an antioxidant that outperforms vitamins A, C, and E and eliminates free radicals that accelerate aging and cause disease. Lipoic Acid Powder also has a variety of beneficial effects on the human body. Lipoic acid is a limiting essential nutrient required by cells to produce energy from energy sources such as sugar, and Lipoic Acid CAS 62-46-4 is also an effective antioxidant and heavy metal chelator. Lipoic acid can be synthesized in appropriate amounts by the body, but its synthesis is not sufficient to meet the required amount when under stress or disease. As with many important substances in the body, Lipoic acid CAS 62-46-4 levels decline with age.

Lipoic acid Raw Materials has a unique versatility among many antioxidants. It is both water-soluble and fat-soluble and protects all tissues and interstitial spaces of the body. It is capable of resisting a wide range of free radicals such as oxidizing anions, hydroxide ions, singlet oxygen and hydrogen peroxide, as well as chelating (binding and neutralizing) with metal ions (e.g., iron, copper, cadmium, lead, mercury, and other metal ions) to catalyze the generation of free radicals.

Another important function of Lipoic acid Powder is to lower blood sugar. Due to its combination of antioxidant, metal chelating and hypoglycemic properties, lipoic acid prevents hyperglycemia and cross-link formation.

Lipoic Acid Powder is a coenzyme present in the mitochondria, similar to vitamins, which can eliminate free radicals that accelerate aging and cause disease.Lipoic Acid CAS 62-46-4 is absorbed through the intestines and enters the cells, and is both fat-soluble and water-soluble, so it can pass through the whole body unhindered and reach any cellular part, providing the body with comprehensive performance. It is a fat-soluble and water-soluble universal antioxidant.

Applications / Functions of Lipoic Acid Powder

Lipoic acid CAS 62-46-4 refers specifically to the naturally occurring form, which was first isolated from pig liver by Reed in 1951. Lipoic acid is a disulfide compound of a class of vitamins, which are usually regarded as B vitamins. Lipoic acid is an important coenzyme in living organisms, an essential cofactor for pyruvate dehydrogenase, ketoglutarate dehydrogenase, and aminocaproate dehydrogenase, and is one of the essential substances in the tricarboxylic acid cycle. The human body is capable of synthesizing sufficient amounts of lipoic acid on its own, and no patients with lipoic acid deficiency have yet been identified. However, in vitro supplementation with lipoic acid has been found to inhibit lipid oxidation in nerve tissue, prevent glycosylation of proteins, inhibit aldose reductase, and prevent the conversion of glucose or galactose to sorbitol, and has been used as a treatment for diabetic neuropathy or neurological complications in Europe.

In addition to playing the role of coenzyme, Lipoic acid Raw Materials also has a powerful antioxidant function, can eliminate free radicals that lead to accelerated aging and disease-causing, with antioxidant, anti-aging, improve immunity, prevention of cardiovascular disease, alleviate the symptoms of diabetes and other functions. With the rise of antioxidant foods, Lipoic Acid Powder is transitioning from traditional medicinal use to consumption. In view of its powerful healthcare functions, the Japanese Ministry of Health, Labor and Welfare reclassified it from a drug to a food product in June 2004, and in addition, the United States, Canada and other regions have classified alpha lipoic acid as a dietary supplement.

• 1.Lipoic acid Powder is a B vitamin that prevents the glycosylation of proteins and inhibits the enzyme aldose reductase, which prevents the conversion of glucose or galactose to sorbitol, so it is mainly used for the treatment and alleviation of peripheral neuropathy caused by the advanced stage of diabetes mellitus.
• 2.Lipoic acid CAS 62-46-4 is a super strong antioxidant, which can preserve and regenerate other antioxidants, such as vitamin C and E, etc., and can balance blood glucose concentration, effectively enhance the body's immune system, free from free radicals from the destruction of the energy metabolism, increase the other antioxidants to eliminate free radicals, to promote the restoration of insulin sensitivity, and to enhance the ability of the human body to build muscle and reduce fat. It can enhance the ability of human body to increase muscle mass and reduce fat, activate cells, anti-aging and beauty.
• 3.Lipoic acid Raw Materials can strengthen the function of liver activity, so that the energy metabolism rate increased, and make us eat food quickly into energy, eliminate fatigue, so that the body does not easily feel tired.

Antioxidative mechanism of Lipoic acid Powder

Lipoic acid Powder has a powerful antioxidant ability, which is 400 times better than VC and VE, it can remove the active oxygen components that cause skin aging, and it is smaller than VE, plus it is both water and fat soluble, so it is easily absorbed by the skin.

Lipoic acid CAS 62-46-4 is not only highly resistant to prolonged oxidative damage, but it is also effective in repairing more severe cellular oxidative damage that cannot be repaired by VC and VE.

It is pointed out that Lipoic Acid Raw Materials can be converted into Dihydrolipoic Acid in the body, both of which have strong antioxidant properties and work synergistically in the body. Meanwhile, the molecular weight of Lipoic acid Raw Materials is between ascorbic acid and tocopherol, and it has the amphiphilicity of water and lipid, so it can play a comprehensive antioxidant effect in the body, which is known as "universal antioxidant".The antioxidant efficacy of Lipoic acid CAS 62-46-4 is reflected in three main aspects:

• 1, direct scavenging of free radicals, Lipoic acid Powder can directly scavenge free radicals such as hydroxyl radicals and mono-linear oxygen after entering cells;
• 2, inhibit metal-induced oxidation, Lipoic acid CAS 62-46-4 has the effect of chelating metal ions, thus reducing the peroxidation of lipids and other macromolecules caused by metal ions;
• 3、Promote the recovery of other antioxidant components, Lipoic acid Powder can restore the ability of endogenous antioxidants such as vitamin E, glutathione, etc. in the body, thus enhancing the overall antioxidant capacity of the body.

Production methodprocess of Lipoic acid Powder

(1) Take sodium sulfide in a beaker, add distilled water to the beaker, and heat and stir it below 50°C to dissolve it to form a 3 mol/L sodium sulfide solution; add sulfur to the resulting sodium sulfide solution, and stir it to dissolve it, so that the concentration of sulfur in the sodium sulfide solution is 3.5 mol/L, and obtain a mixed solution;

(2) Add ethyl 6,8-dichlorooctanoate and distilled water sequentially to the photoreactor to formulate a 3 mol/L ethyl 6,8-dichlorooctanoate solution, and then add a phase transfer catalyst to the solution, and stir to raise the temperature to 82-84 °C;

(3) The mixed solution obtained from step (1) was added dropwise to the reaction solution of step (2) at a volume ratio of 5:3.5 within 180 min, while a 1000 W xenon lamp was used and a cut-off filter of 680 nm was used for photocatalysis of the reaction solution, and the reaction solution was stirred at a speed of 200 r/min;

(4) Sodium sulfite was added to the photoreactor after the cyclization reaction, such that the concentration of sodium sulfite in the reaction solution was 0.45 mol/L, and the reaction was carried out under photocatalysis at 86-90°C for 60 min.

(5) After the reaction was completed, the reaction solution was extracted at 80 to 90°C, the organic layer was diluted with toluene, while the aqueous layer was extracted with toluene, the toluene layers were combined, and then the toluene layer was rotary evaporated to a constant weight, to obtain ethyl thioctanoate; and then the ethyl thioctanoate was hydrolyzed and acidified to obtain Lipoic acid Powder.

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