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Uses and synthesis of L-Methionine Powder

L-Methionine Powder is a sulfur-containing non-polar aliphatic amino acid, also known as methionine, one of the essential amino acids, abbreviated as Met, M. It is an essential amino acid for gluconeogenesis.It was isolated from casein in 1922. It is the only amino acid containing sulfur ether structure. There are l-body and dl-body. The natural product is l-body. Relative molecular mass 149.21, with a special odor. Slightly sweet flavor.

L-Methionine CAS 63-68-3 is an essential amino acid for the nutrition of human and animal body, commonly used in the preparation of complex amino acid infusion, or the treatment of acute hepatitis, cirrhosis of the liver, and the antidote for drugs.DL-Methionine is used in large quantities in the matching feed for cattle, pigs, and young chickens.L-Methionine Raw Materials Metabolism is associated with Cysteine is associated. In prokaryotes, formylated methionine is the starting amino acid for protein biosynthesis.L-Methionine Raw Materials can also be converted to s-adenosylmethionine by ATP activation, which serves as a methyl donor for the synthesis of creatine and choline.L-Methionine Raw Materials can be converted to s-adenosylmethionine by ATP activation.

L-Methionine Powder's main physiological function is to supply methyl.L-Methionine CAS 63-68-3 participates in the biochemical reaction of methyl transfer in vivo by supplying a methyl group (-CH3), which is needed to supply methyl during the synthesis of choline and creatine, and is also needed to supply lysine, histidine, and arginine in some protein molecules.L-Methionine Raw Materials can also be activated by ATP to convert s-adenosylmethionine to s-adenosylmethionine as a methyl donor to participate in the synthesis of creatine and choline. In some protein molecules such as lysine, histidine and arginine, it also needs to supply methyl for methylation, and the free carboxyl group on protein molecules also needs it to supply methyl for methylation. Foods rich in methionine include meat, fish, poultry and eggs. Mixing with legumes and cereals can play a complementary role of protein.

Applications / Functions of L-Methionine Powder

L-Methionine CAS 63-68-3 is used for liver cirrhosis and fatty liver. In addition, it is used as a large number of feed additives to improve the quality of feed, increase the utilization of natural proteins and promote the development of animals. For example, L-Methionine Powder can improve the egg production of chickens, increase the weight of hogs and milk production of cows. Adverse reactions: contraindicated in hepatic coma.

Nutritional supplement. One of the essential amino acids. Because the price is higher than L-Methionine Powder but the effect is equal, so DL-Methionine is commonly used.

L-Methionine Raw Materials are used in biochemical research and nutritional supplements, and also used in the adjuvant treatment of pneumonia, hepatic cirrhosis and fatty liver.

Physicochemical Property of L-Methionine Powder

L-Methionine Raw Materials is white flaky crystal or crystalline powder, special odor, slightly sweet. mp280-282 ℃ (decomposition), no spin, stable to heat and air, unstable to strong acid, can lead to demethylation. Soluble in water (3.5%, 25 ℃), dilute acid and dilute alkali solution, very difficult to dissolve in ethanol, insoluble in ether. Isoelectric point 5.74.

L-Methionine Powder is non-toxic and can be used as feed additive. However, it is reported that ingestion of large quantities of this product will cause vomiting, loss of appetite and other symptoms. For rats, intraperitoneal injection, L-type: LD50 is 29mmol/kg; D-type: LD50 is 35mmol/kg. special attention should be paid to the use of highly toxic raw material sodium cyanide in the production process of methionine, so the production workshop should be in accordance with the requirements of the toxicity of sodium cyanide to protect the appropriate measures: equipment should be sealed, the production site should be well ventilated, the operator should wear protective equipment, and so on.

L-Methionine CAS 63-68-3 is known as methylthiobutyric acid. It is one of the essential amino acids. White flaky crystals or crystalline powder, with special odor. Molecular weight 149.21.DL-Methionine(Racemic) melting point 281°C(Decomposition). relative density 1.340. soluble in water. Relative density 1.340. soluble in water, dilute acid and dilute alkali, slightly soluble in 95% ethanol, insoluble in ether.

L-Methionine Powder (levulose) melting point 280 ~ 281 ℃ (decomposition). Soluble in water and hot dilute alcohol. Insoluble in anhydrous ethanol, ether, petroleum ether, benzene and acetone.D-Methionine (dextrose) melting point 273 ° C (decomposition). Soluble in water, dilute acid and alkali, very slightly soluble in alcohol, insoluble in ether. Generally amino acid dextransformers are biochemically ineffective, with the exception of methionine.Both D-Methionine and L-Methionine Raw Materials are potent generative enhancers due to the ability of D-Methionine to be converted to L-Methionine in living organisms. Therefore the synthesized DL-Methionine does not need to be dialyzed and is applied directly. Methionine is an essential amino acid for animal bodies and is one of the components that make up proteins.

L-Methionine Raw Materials maintains the growth and development of the body and nitrogen balance. It cannot be synthesized in the animal's body and must be supplied from outside the body in the form of amino acids or proteins. Methionine is an important feed additive (nutritional enhancer).

L-Methionine CAS 63-68-3 is mainly used in food as a flavoring agent with amino acids such as glycine, alanine, valine and glutamic acid. In medicine, methionine is one of the main components of amino acid infusion and compound amino acid preparation.

L-Methionine Powder is also used in the prevention and treatment of liver diseases and poisoning by arsenic and benzene. It is also used as a protein nutritional supplement for patients with protein deficiency or insufficient absorption. It is obtained by the addition of methyl mercaptan and acrolein followed by the reaction with sodium cyanide and ammonium chloride to produce α-aminonitrile, which is then hydrolyzed. It can also be obtained from casein by hydrolysis and refining.

Production methodprocess of L-Methionine Powder

Produced from acetyl-DL-methionine by splitting the spin by amylase.

Technical route

The process of dehydration is based on the dosage ratio of glycerol, potassium bisulfate and potassium sulfate at 1:0.5:0.026. Firstly, put 1/7 of glycerol and all of potassium bisulfate and potassium sulfate into the reaction tank, and then start to add the rest of glycerol dropwise after warming up to 190℃, and then control the temperature of reaction 180-220℃, and the acrolein gas generated by the reaction will be collected in the tank through condenser, and then get the crude product of acrolein.

The crude product with 10% NaHCO3 solution to pH 6, for fractionation, collect 50-75 ℃ fraction, acrolein crude product. Add according to acrolein, methyl isothiourea sulfate, sodium hydroxide, copper acetate, formic acid to 1:2.45:3.8:0.01:0.024 ratio of proportional feeding. The cyclic synthesis was first put methylisothiourea sulfate into the methyl mercaptan generating tank, NaOH solution was added dropwise and heated at the same time to control the temperature not exceeding 95 ℃, and the generated methyl mercaptan firstly entered into the buffer tank, then entered into the washing tank containing 50% of sulfuric acid solution and the other first-stage rinsing tank, and finally entered into the addition tank in which acrolein, formic acid, and copper acetate were preinputted, heated and stirred to keep the reaction temperature at 35-41 ℃. When the reaction is close to the end, the reaction was light yellow and mixed with flocculent, and from time to time to determine its relative density, when the relative density of 1.066-1.074 (20 ℃) when the reaction has reached the end. Get 3-methylthiopropionaldehyde. According to 3-methylthiopropionaldehyde, sodium cyanide, ammonium bicarbonate to 1:0.52:1.75 ratio of the ingredients.

Ammonium bicarbonate dissolved in 4 times its weight in water and sodium cyanide dissolved in 3 times its weight in water, respectively, put into the reaction tank, under stirring slowly add 3-methylthiopropionaldehyde, and keep warm at 75-80 ° C reaction for 3h, to get the acylurea. Hydrolysis will be 1.1 parts of lime made of lime milk, another 0.424 parts of sodium hydroxide solution into the reaction tank, and then add 1 part of the acetylurea, alkali hydrolysis at elevated temperatures and discharge of ammonia for 1h, holding temperature of 165 ℃, the pressure of 0.5MPa, the reaction for 1h, DL-methionine sodium salt. Neutralization, decolorization of the above DL-methionine sodium salt plus HCl pH5-6, activated carbon 1% boiled for 45min, while hot, filtration slag, collect the filtrate, cooling crystallization, filtration of the crystals, dried at 100 ℃ to get the DL-methionine crude product.

Refining according to the crude, distilled water, activated carbon, EDTA to 1:7:0.04:0.0007 ratio of proportional feeding, will be put into the refining tank, stirring, decolorization 1.5h, filtration and dregs, collection of filtrate, cooling placed 15-20h crystals, filtration and crystallization, drying, DL-methionine finished products.

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