Factory Supply Tauroursodeoxycholic acid Powder CAS 14605-22-2 Raw Materials

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Uses and synthesis of Tauroursodeoxycholic acid Powder

Tauroursodeoxycholic acid Powder is the main active ingredient of bear bile Tauroursodeoxycholic acid Raw Material is also the main ingredient of synthetic bear bile, widely found in the bile of human beings and many kinds of animals, a kind of binding bile acid, has a variety of physiological and pharmacological effects. Tauroursodeoxycholic acid CAS 14605-22-2 and its preparations have been on the market for twenty years in foreign countries, mainly used for steroidal gallbladder stones, biliary liver disease (e.g., primary biliary cirrhosis), bile reflux gastritis, autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (Sclerosing Cholangitis), and biliary cirrhosis (PBC). sclerosing cholangitis (PSC), chronic hepatitis (Hepatitis B, Hepatitis C, etc.), alcoholic fatty liver disease, non-alcoholic fatty liver disease, drug-induced liver damage, prevention and treatment of complications before and after liver transplantation.

Tauroursodeoxycholic acid Raw Materials is chemically known as 3α,7β dihydroxycholanoyl-N-taurine, which is a bound bile acid formed by the condensation between the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine.

Tauroursodeoxycholic acid CAS 14605-22-2 is a combined bile acid formed by the condensation between the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine.TUDCA was discovered in 1902 from bear bile, and is the main bile acid in bear bile, which has the effects of antispasmodic, anticonvulsant, anti-inflammatory, and cholecalciferolysis.

Applications / Functions of Tauroursodeoxycholic acid Powder

Tauroursodeoxycholic acid CAS 14605-22-2, also known as tauroursodeoxycholic acid, tauroursodeoxycholic acid, chemical name is 3α,7β dihydroxycholanoyl-N-taurine, mainly in the black bear bile, is the hallmark of bear bile in the active ingredients. It has antispasmodic, anticonvulsant, anti-inflammatory and cholelitholytic effects.

Tauroursodeoxycholic acid Powder has antispasmodic, anticonvulsant, anti-inflammatory and cholelitholytic effects. It is mainly used clinically for the treatment of gallbladder cholesterol stones, primary sclerosing cholangitis, primary biliary cirrhosis, and chronic viral hepatitis C, among others.

Biochemical research; Lipase accelerator; Anion remover, Tauroursodeoxycholic acid Raw Material for protein solubilization; Preparation of bacterial culture media (intestinal bacterial culture and isolation)

Tauroursodeoxycholic acid Powder is used for content determination/identification/pharmacological experiments.

Drug action and clinical application of Tauroursodeoxycholic acid Powder

Tauroursodeoxycholic acid Powder is also known as tauroursodeoxycholic acid, tauroursodeoxycholic acid, the chemical name is 3α, 7β dihydroxycholanoyl-N-taurine, mainly in the black bear bile, is the hallmark of bear bile in the active ingredients. It has antispasmodic, anticonvulsant, anti-inflammatory and cholelitholytic effects.

The modern synthetic drug Tauroursodeoxycholic acid CAS 14605-22-2, is a combined bile acid formed by condensation between the shuttle group of ursodeoxycholic acid and the amino group of taurine. Tauroursodeoxycholic acid capsules have been marketed abroad and were approved for sale in China as imported drugs in 2007.Clinical Tauroursodeoxycholic acid Raw Material is mainly used for the treatment of gallbladder cholesterol stones, primary sclerosing cholangitis, primary biliary cirrhosis, and chronic viral hepatitis C. Currently Tauroursodeoxycholic acid Raw Material and its preparations have no drug registration in China. Tauroursodeoxycholic acid sodium is a kind of natural bile acid isolated from bear bile, which is a chemical preparation, combined with taurine in the body and exists in bile, is a kind of hydrophilic bile acid, and is a kind of cholesterol stone dissolver. It can reduce the secretion of cholesterol by liver, lower the saturation of cholesterol in bile, promote the secretion of bile acids, increase the solubility of cholesterol in bile, and dissolve cholesterol stones or prevent the formation of stones. It can increase bile secretion, relax the bile duct sphincter to produce choleretic effect, which is conducive to the discharge of stones.

Tauroursodeoxycholic acid Powder cannot dissolve other types of gallstones. It is suitable for the treatment of cholesterol stones, hyperlipidemia, bile secretion disorders, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis, and the prevention of acute rejection of liver transplants, etc. Tauroursodeoxycholic acid CAS 14605-22-2 has a slightly weaker stone dissolving effect than Goose Deoxycholic Acid.

Production methodprocess of Tauroursodeoxycholic acid Powder

• 1) The preparation of Tauroursodeoxycholic acid CAS 14605-22-2 crude product was carried out according to the following steps: In the reaction kettle, 4.0KG ursodeoxycholic acid was added, 19KG acetone was added, and 1,650ml of triethylamine was added with stirring, and the jacket refrigeration was turned on, and the temperature of the mixture was lowered to -10℃. Flow add ethyl chloroformate 1120ml, control the adding speed of ethyl chloroformate, make the reaction liquid temperature is maintained between -5-0 ℃, 30 minutes when added, continue to maintain the temperature of stirring reaction for 40 minutes to produce ursodeoxycholic acid and ethyl chloroformate mixed anhydride, will be the above mixed anhydride reaction liquid through the filter with nitrogen pressure filtration to be equipped with 4.2 KG purified water, 1.4 KG taurine, 1.4 KG sodium hydroxide, 0.4 KG taurine, 0.4 KG sodium hydroxide. 0.4 KG of sodium hydroxide in a 50-liter reaction kettle with full stirring for 3 hours, and further produced 4.0 KG of crude tauroursodeoxycholic acid.
• 2) Tauroursodeoxycholic acid Powder Refinement of crude product, according to the following steps: (1) 4.0KG tauroursodeoxycholic acid into the 50L reaction kettle, add 4KG of water and 580ml of acetone,, heating and stirring until all dissolved; (2) cooling to -5-0 ℃ with stirring, precipitation of crystals for 30 hours;
• (3) Discharge to the filter in the extraction of filtration, after draining the filter cake with ice water (-3-0 ° C) showered with ice water (-3-0 ° C), once again drained, to get taurine ursodeoxycholic acid 3.3KG (purity of 99.6%, HPLC), which taurine goose goose deoxycholic acid content of 0.3%, the other largest single heterogeneous content of 0.05% (measured by liquid chromatography).

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