Sofosbuvir powder Raw Materials CAS 1190307-88-0

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Uses and synthesis of Sofosbuvir powder

Sofosbuvir powder, a new candidate for the treatment of hepatitis C, previously known as PS-7977 or GS-7977, has shown encouraging results in a number of in vitro studies on all HCV genotypes. Sofosbuvir is a nucleotide analogue that is a potent inhibitor of NS5B polymerase in HCV. Sofosbuvir powder, a prodrug that can be metabolized into the active antiviral 2' -deoxy-2 '-alpha-fluoro-beta-C-methyluridine 5' -monophosphate, is currently in Phase 3 clinical trials for the treatment of hepatitis C. Studies have shown that Sofosbuvir is a nucleotide inhibitor of hepatitis C virus and has a selective inhibitory effect on HCVNS5B polymerase.

Applications/Functions of Sofosbuvir powder

1. Sofosbuvir powder is a hepatitis C virus (HCV) nucleotide analogue NS5B polymerase inhibitor indicated as a combination ingredient in a combined antiviral regimen for the treatment of chronic hepatitis C (CHC) infection.
2. Sofosbuvir has been shown to be effective in the treatment of HCV genotype 1, 2, 3, or 4 in patients with hepatocellular carcinoma who meet the Milan criteria and are awaiting liver transplantation, as well as in patients co-infected with HCV/HIV-1.

Physicochemical Property of Sofosbuvir powder

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