Factory Supply 4-Chloroaniline Powder CAS 106-47-8 Raw Materials

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Uses and synthesis of 4-Chloroaniline Powder

4-Chloroaniline Powder is a white or yellow crystal with a melting point of 341-344 K and a boiling point of 505 K. It is easily soluble in ethanol, ether, acetone and carbon disulfide.4-Chloroaniline CAS 106-47-8 is an important raw material in the production of fine chemical industry, and it is widely used in the fields of synthetic pharmaceuticals, pesticides, rubber and daily-use chemicals, etc. The demand for 4-Chloroaniline CAS 106-47-8 increases with the development of chemical industry. It is widely used in synthetic medicine, pesticide, rubber and daily-use chemical industry, etc. The demand for 4-Chloroaniline CAS 106-47-8 is increasing day by day with the development of chemical industry.

At present, most of 4-Chloroaniline CAS 106-47-8 is produced by the reduction of p-chloronitrobenzene, and the reduction methods mainly include metal reduction, electrochemical reduction, non-hydrogen reductant reduction, catalytic hydrogenation reduction, etc. Among them, the catalytic hydrogenation reduction method is advanced and has a high yield, which is more in line with the requirements of modern chemical industry on the economy of the atom;

Among them, the catalytic hydrogenation of noble metals occupies a major position, and the multiphase catalytic reduction method under high temperature and high pressure was mainly used in the past, but due to the high temperature microcrystals are easy to gather on the surface of the carrier, which affects its dispersion, and then affects the catalytic activity of the catalyst, and in recent years, multiphase catalysis under low temperature and low pressure is gradually attracting the interest of scientific researchers. The key point of catalytic hydrogenation is how to control the reaction selectivity and prevent the occurrence of dechlorination side reactions.

Applications / Functions of 4-Chloroaniline Powder

1. 4-Chloroaniline Powder is the intermediate of azo dyes and chromophenol AS-LB, and also the raw material of pharmaceuticals such as Librium, Finasteride and pesticides, and is also used in the production of color film coloring agent.
2. 4-Chloroaniline CAS 106-47-8 can be synthesized directly into diflubenzuron, or through p-chlorophenyl urea or p-chlorophenyl isocyanate to synthesize the two varieties of diflubenzuron and diflubenzuron, or through 2-chloro-4-aminophenol to synthesize cyclobenzuron, 4-Chloroaniline CAS 106-47-8 is also the herbicide saxamoxifrazin and plant growth regulator. 4-Chloroaniline CAS 106-47-8 is also an intermediate for the herbicide cintofen and the plant regulator cintofen. In addition, 4-Chloroaniline is an intermediate in dyes, pharmaceuticals, and a coloring agent in the production of color motion picture films.
3. 4-Chloroaniline Raw Materials is an intermediate for the herbicide sabaquat, the insecticide methomyl, and the plant growth regulator antiflagellate.
4. 4-Chloroaniline Powder is used as an intermediate for azo dyes and the manufacture of the color phenol AS-LB. It is also used as the intermediate of medicine (such as Librium, Fenaza tincture) and pesticide. Also used in the production of color film coloring agent. At present, China's dyestuff industry consumes about 350t of p-chloroaniline, of which about 160t of p-chloroaniline is needed for color phenol AS-LB, about 60t of organic pigment permanent yellow, and about 80t of p-chloro-pyrazolone. in pharmaceutical industry, the output of Librium and other medicines is between 15-20t per year, and the production of these medicines needs about 150t of p-chloroaniline. in 1991, China's export of p-chloroaniline was 10t only.
5. 4-Chloroaniline Raw Materials Used as Dye Intermediates
6. 4-Chloroaniline Raw Materials is used as the intermediate of azo dyes and color phenol AS-LB, and also used as the intermediate of pharmaceuticals such as Librium, Fenaza tincture, etc. It can be used as the intermediate of azo dyes and color phenol AS-LB.
7. Chloroaniline CAS 106-47-8 is used as an intermediate in the manufacture of azo dyestuffs and chromophenols AS-LB, and is also used as an intermediate in the manufacture of pharmaceuticals such as Librium and Fenaza tincture.

Physicochemical Property of 4-Chloroaniline Powder

Chloroaniline CAS 106-47-8 White or light yellow crystal. Soluble in hot water, easily soluble in ethanol, ether, acetone, carbon disulfide and other common organic solvents.

production methodprocess of 4-Chloroaniline Powder

1. 1 Iron powder reduction method after the reduction reaction, neutralized with soda ash, and then distilled to obtain 98% purity of industrial products. When using iron powder reduction method for laboratory preparation, the aqueous solution of acetic acid can be heated to boiling, iron powder is added under vigorous stirring, and p-nitrochlorobenzene is added in portions after 15 min. Yield 74%.2. Hydrogenation reduction method dissolve p-nitrochlorobenzene in alcohol, use nickel skeleton as catalyst, hydrogenation reduction at 100 ℃, about 4MPa pressure. Then separate the solvent and catalyst and get the finished product. Raw material consumption quota: p-nitrochlorobenzene 1390kg/t, iron powder 1560kg/t, hydrochloric acid (30%) 440kg/t.
2. The preparation method is to use p-chloronitrobenzene as raw material, Raney nickel as catalyst, ethanol as solvent, reaction temperature 50-70℃, hydrogenation pressure 3.04-3.55MPa, medium pH=5-6 conditions, catalytic hydrogenation reaction, to obtain Chloroaniline CAS 106-47-8.
3. Chloroaniline is prepared by reducing nitrochlorobenzene to obtain p-chloroaniline, and there are several methods such as iron powder reduction, hydrogenation reduction and zinc powder reduction.

• Iron powder reduction

Mix p-chloronitrobenzene, water and iron powder and heat to 95℃, after p-chloronitrobenzene completely dissolved, add concentrated hydrochloric acid drop by drop, adjust the drop acceleration to keep the temperature at 25℃, continue the reaction for 25h after the drop is completed, cool it down, add too much sodium hydroxide to make the solution alkaline, and distill the oil layer to get Chloroaniline CAS 106-47-8.

• Hydrogenation reduction method

P-chloronitrobenzene and ethanol according to the mass ratio of 1:1.5 mixed, add Ranieri nickel (from 100 mesh nickel-aluminum binary alloy) as a catalyst, at a temperature of 50 ~ 70 ℃, the pressure of 2.94 ~ 3.43MPa, the medium pH = 5 ~ 6 under the conditions of the reaction of hydrogen for 2h, the resulting crude at atmospheric pressure to evaporate out of the ethanol and part of the water, and then distilled under reduced pressure that is, the finished product. In addition, there is also p-chloronitrobenzene and zinc powder in the acetic acid medium for reduction, can be higher yield to get 4-Chloroaniline Raw Materials, but the price of zinc powder is higher.

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