Berberine powder Raw Materials CAS 2086-83-1

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Uses and synthesis of Berberine powder

Berberine powder is a quaternary ammonium alkaloid with strong antibacterial action. It has yellow needle-like crystals and bitter taste. It is the main effective ingredient of Coptis. In the plant kingdom, Berberine is widely distributed, and it is found in about 10 genera of plants in 4 families. It is the main active ingredient extracted from the rhizomes of Coptis of the Goldenseal family. It exists in the form of quaternary ammonium salt in nature, and its hydrochloride is commonly used in clinic. Berberine powder has many pharmacological effects such as anti-microbial, anti-arrhythmia, hypolipidemia, hypoglycemia, anti-inflammatory, anti-tumor, sedative and hypnotic. Due to its unique antibacterial properties, berberine has a wide range of applications in medicine and agriculture.

Applications/Functions of Berberine powder

1. Berberine powder is an antibacterial drug. It has antibacterial effects on hemolytic streptococcus, staphylococcus aureus, gonorrhoeae, Fredri and Shigella dysenteriae, and can enhance white blood cell phagocytosis. It can also inhibit tuberculosis bacillus and yersinia pestis to varying degrees.
2. Berberine is widely used to treat gastroenteritis, bacillary dysentery, tuberculosis, scarlet fever, acute tonsillitis and respiratory infections.
3. Berberine A plant antibiotic used to treat intestinal infections

Physicochemical Property of Berberine powder

Berberine is a common isoquinoline alkaloid. The yellow acicular crystal precipitated from the ether has a melting point of 145℃. Soluble in water, insoluble in benzene, ether and chloroform. It has the characteristics of quaternary amine salt.

Production methodprocess of Berberine powder

Using safrole as raw material, isosafrole was obtained by isomerization under reduced pressure, and piperaldehyde was synthesized by oxidation. Piperaldehyde is condensed with nitromethane to obtain β-nitro-3, 4-dioxylene styrene, further reduced to piperitylamine, piperitylamine is condensed with o-veratraldehyde, and then by catalytic hydrogenation, salting, cyclization, and alkalization to berberine. Berberine powder is produced by continuing to salt with hydrochloric acid.

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