2-Deoxy-D-glucose powder Raw Materials CAS 154-17-6

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Uses and synthesis of 2-Deoxy-D-glucose powder

2-Deoxy-D-glucose powder is an antimetabolite of D-glucose, 2-Deoxy-D-glucose CAS 154-17-6 has the effect of interfering with the synthesis of virus-specific glycoproteins, inhibiting the proliferation of herpes simplex viruses, RAN and DNA-enveloped viruses, and cancer cells.

Applications / Functions of 2-Deoxy-D-glucose powder

2-Deoxy-D-glucose Raw Materials is a natural antimetabolite antibiotic, which can inhibit viral infections, yeast fermentation, pathogenic bacteria and tumour cell growth.

Physicochemical Property of 2-Deoxy-D-glucose powder

2-Deoxy-D-glucose powder is a derivative of D-glucose, 2-Deoxy-D-glucose CAS 154-17-6 is a kind of antimetabolite, which has the ability to interfere with the synthesis of virus-specific glycoproteins, and can effectively inhibit the proliferation of herpes simplex viruses, RNA and DNA enveloped viruses, and breast cancer cells.

Production methodprocess of 2-Deoxy-D-glucose powder

The intermediate 2-Deoxy-1,3,4,6-tetra-O-acetyl-D-glucose 1.0 g was added to 10 mL of hydrochloric acid at a concentration of 37% to carry out an acid-catalyzed hydrolysis reaction at a temperature of 75 ° C and a reaction time of 4 h. After the reaction, it was cooled down to room temperature, and after removing the acetyl group, the product was neutralized with a 50% (wt%) sodium hydroxide solution to pH = 7.

Then, the reaction solution was extracted twice with 10 mL of methanol solvent, and the combined extracts were evaporated under reduced pressure at a temperature of 28°C and a pressure of 0.1 MPa, and the resulting solid was recrystallised with 10 mL of a solvent mixed with methanol and acetone at the ratio of 1:1.5 by volume, and then filtered and dried under reduced pressure and vacuum to obtain the white crystalline solid 2-Deoxy-D-glucose Raw. Materials 0.41g, the yield was 81%.

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