Albendazole powder Raw Materials CAS 54965-21-8

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Uses and synthesis of Albendazole powder

Albendazole powder, developed by Schbichem (the predecessor of GlaxoSmithKline), is a broad-spectrum thiabendazole insecticide for both human and veterinary use, which can inhibit the growth and reproduction of insects. Albendazole has the function of completely killing the eggs of hookworm and whipworm and partially killing the eggs of roundworm, killing and repelling various nematodes parasitic in animals, and also has obvious killing and repelling effects on tapeworms and cysticercus. Albendazole powder is suitable for the treatment of hydatids (echinococcosis) and nervous system infections (cysticercosis) caused by streptozoa in pork, as well as for hookworms, roundworms, pinworms, trichotrichodes, tapeworms, whipworms, and strongyloidiasis

Applications/Functions of Albendazole powder

1. Albendazole powder is an effective broad-spectrum dewormer. It can block the absorption of various nutrients and glucose by the insect body, resulting in the depletion of glycogen, which makes the parasite unable to survive and reproduce. It is used to treat single or mixed feelings caused by roundworm, pinworm, whipworm, hookworm, etc.
2. Albendazole is a highly effective, broad-spectrum insecticidal drug, and has significant effects on liver fluke, tapeworm, lung and gastrointestinal nematodes. Benzimidazole is the strongest of the benzimidazole drugs, is currently the first choice for the prevention and treatment of livestock and poultry parasitic diseases.
3. Albendazole powder is used to control Chinese cabbage downy mildew, rice blast, tobacco powdery mildew, anthrax, etc.

Pharmacological Actions of Albendazole.

Inhibit microtubule polymerization ‌
As a benzimidazole derivative, its active metabolite albendazole sulfoxide (ABZSO) binds to parasite β-tubulin, destroys microtubule structure, and interferes with cell division and transport function.

‌Blocking energy metabolism ‌
Inhibits glucose uptake by the parasite, leading to glycogen depletion;
Inhibits the fumarate reductase system and hinders ATP production.

‌Broad-spectrum insecticidal activity ‌
It has a significant inhibitory effect on the development of nematodes (ascaris, hookworms, etc.), tapeworms, cysticerci and eggs, and the rate of negative conversion of anthelmintic eggs can reach 70%-100%.

‌Tissue permeability ‌
The metabolite ABZSO can penetrate cysts or lesion tissues (such as brain and liver) to treat cysticercosis and echinococcosis

How to use Albendazole correctly?

1. Dosage and course of treatment
‌ Conventional anthelmintic treatment ‌ ‌ Adults and children over 12 years old: 400 mg is recommended for roundworm and pinworm infection; 400 mg/time, twice a day, for hookworm and whipworm infection, for 3 consecutive days.

‌ Children: Adjust the dose according to body weight, 10-15 mg/kg (no more than 400 mg per time), 200 mg/time for those weighing less than 15 kg, 400 mg/time for those weighing 15-30 kg.

‌ Severe infection ‌ (such as cysticercosis, echinococcosis): 20 mg/kg/day should be taken in divided doses, the course of treatment is 1 week to several months, and repeated every 7-10 days.

‌ Special populations ‌ ‌ Pregnant women are prohibited, and breastfeeding should be suspended for 3 days during lactation; ​ Those with liver and kidney dysfunction need to extend the dosing interval or reduce the dose.

2. Time and method of taking medicine
‌Take on an empty stomach‌: Take it in the morning or 3 hours before going to bed without eating to improve the absorption rate;

‌Take it after meals‌: People with gastrointestinal sensitivity can take it 30 minutes after meals to reduce irritation;

‌Swallow the whole tablet‌: Avoid chewing or crushing. People with difficulty swallowing can soften it and take it with water.

3. Precautions
‌Drug interactions‌: Avoid using it in combination with glucocorticoids and anti-epileptic drugs, which may affect the efficacy or increase adverse reactions;

‌Adverse reaction monitoring‌: Nausea, headache, rash, etc. may occur. If it is serious, you need to stop taking the medicine and seek medical treatment;

‌Health management‌: Clothes need to be disinfected at high temperature during treatment to avoid repeated infection.

4. Reexamination and follow-up
Fecal ova can be reexamined 2 weeks after routine infection treatment;

Cysticercosis and other diseases require imaging follow-up to ensure the removal of worms

Physicochemical Property of Albendazole powder

Prothiobenidazole, also called Albendazole, white to light yellow crystalline powder, odorless, melting point 208 ~ 210℃, insoluble in water, slightly soluble in hot dilute hydrochloric acid, acetone or chloroform, soluble in methanol, ethanol or acetic acid.

Production methodprocess of Albendazole powder

O-nitroaniline was used as raw material. O-nitroaniline first reacts with sodium thiocyanate to form 2-nitro-4-thiocyanide in the condition of chlorination, then reacts with bromopropane to form 2-nitro-4-propyl thiocyanide, which is reduced by sodium sulfide to 2-amino-4-propyl thiocyanide, and finally synthesizes Albendazole powder with methyl cyanoformate

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