Albendazole powder Raw Materials CAS 54965-21-8

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Uses and synthesis of Albendazole powder

Albendazole powder, developed by Schbichem (the predecessor of GlaxoSmithKline), is a broad-spectrum thiabendazole insecticide for both human and veterinary use, which can inhibit the growth and reproduction of insects. Albendazole has the function of completely killing the eggs of hookworm and whipworm and partially killing the eggs of roundworm, killing and repelling various nematodes parasitic in animals, and also has obvious killing and repelling effects on tapeworms and cysticercus. Albendazole powder is suitable for the treatment of hydatids (echinococcosis) and nervous system infections (cysticercosis) caused by streptozoa in pork, as well as for hookworms, roundworms, pinworms, trichotrichodes, tapeworms, whipworms, and strongyloidiasis

Applications/Functions of Albendazole powder

1. Albendazole powder is an effective broad-spectrum dewormer. It can block the absorption of various nutrients and glucose by the insect body, resulting in the depletion of glycogen, which makes the parasite unable to survive and reproduce. It is used to treat single or mixed feelings caused by roundworm, pinworm, whipworm, hookworm, etc.
2. Albendazole is a highly effective, broad-spectrum insecticidal drug, and has significant effects on liver fluke, tapeworm, lung and gastrointestinal nematodes. Benzimidazole is the strongest of the benzimidazole drugs, is currently the first choice for the prevention and treatment of livestock and poultry parasitic diseases.
3. Albendazole powder is used to control Chinese cabbage downy mildew, rice blast, tobacco powdery mildew, anthrax, etc.

Physicochemical Property of Albendazole powder

Prothiobenidazole, also called Albendazole, white to light yellow crystalline powder, odorless, melting point 208 ~ 210℃, insoluble in water, slightly soluble in hot dilute hydrochloric acid, acetone or chloroform, soluble in methanol, ethanol or acetic acid.

Production methodprocess of Albendazole powder

O-nitroaniline was used as raw material. O-nitroaniline first reacts with sodium thiocyanate to form 2-nitro-4-thiocyanide in the condition of chlorination, then reacts with bromopropane to form 2-nitro-4-propyl thiocyanide, which is reduced by sodium sulfide to 2-amino-4-propyl thiocyanide, and finally synthesizes Albendazole powder with methyl cyanoformate

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