Ampicillin sodium powder Raw Materials CAS 69-52-3

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Uses and synthesis of Ampicillin sodium powder

​Ampicillin sodium powder is a broad spectrum penicillin, white or white like powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. The antibacterial spectrum is wider than that of penicillin, and it also has antibacterial activity against some gram-negative bacilli (such as Haemophilus influenzae, Escherichia coli, Proteus mirabilis). The effect on gram-positive cocci is similar to that of penicillin. Ampicillin sodium can also be hydrolytically inactivated by penicillinase produced by bacteria. Clinical application for the treatment of sensitive bacteria caused by respiratory tract infection, urinary tract infection, gastrointestinal infection, skin soft tissue infection, meningitis, sepsis, endocarditis and so on. Ampicillin sodium is the drug of choice for enterococcal infections.

​​​​​Applications/Functions of Ampicillin sodium powder

1. ​Ampicillin sodium powder is a semi-synthetic broad spectrum penicillin, mainly used for the treatment of gram-positive coccus, Escherichia coli, Proteus, Salmonella, dysentery, etc
2. ​Semi-synthetic penicillin, resistant to gram-positive and gram-negative bacteria.
3. It is a beta-lactamase antibiotic with an amino group chain attached to the penicillin structure. A derivative of penicillin, it inhibits the synthesis of bacterial cell walls by inactivating transpeptidases at the inner layer of bacterial cell membranes.

​​​Physicochemical Property of Ampicillin sodium powder

​​​Ampicillin sodium a white or whitelike powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. It has hygroscopicity, and the aqueous solution gradually turns yellow at room temperature, resulting in turbidity, and the titer gradually decreases. Odorless, slightly bitter taste.

​​​Production methodprocess of Ampicillin sodium powder

​Ampicillin salt: Ampicillin suspended in water, adjusted to pH 9 with sodium hydroxide solution, dissolved, filtered. The filtrate is decolorized with activated carbon, filtered and dried at low temperature to obtain Ampicillin sodium powder.

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