Food Grade Bromelain Enzyme powder Raw Materials CAS 9001-00-7

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Uses and synthesis of Bromelain powder

Bromelain powder is a natural plant protease prepared by biotechnology from the skin, core and other parts of pineapple fruit. Its molecular weight is 33,000 and its isoelectric point is 9.55. Bromelain mainly contains a variety of ingredients such as proteolytic enzymes. The energy specification is expressed in GDU/g, and the maximum energy specification can reach 3000GDU/g. It is a light yellowish-brown powder with pineapple aroma. Bromelain is a hydrophobic protease, and its active center is hydrophobic (-SH), which can carry out various biochemical reactions such as protein hydrolysis. Bromelain powder can be widely used in food, medicine, biology and other industries.

What is the mechanism of action of bromelain?

1. Proteolytic activity: This is the core mechanism of action of bromelain. It can break down various proteins, including:
Inflammatory mediators: Bromelain can break down proteins involved in inflammatory responses, such as bradykinin, fibrinogen, etc., thereby reducing inflammatory responses.
Blood coagulation factors: In in vitro experiments, bromelain showed a certain anticoagulant effect, which may affect the blood coagulation process. (But the mechanism of action in the human body is more complicated)
Necrotic tissue and thrombus: Bromelain can help break down necrotic tissue and thrombus, promote wound cleaning and blood circulation.
Protein in food: The proteolytic activity of bromelain also makes it a digestive aid, which can help break down protein in food and reduce the burden of digestion.

2. Anti-inflammatory effect: The anti-inflammatory mechanism of bromelain is complex and may involve the following pathways:
Inhibit the production of inflammatory mediators: Bromelain can inhibit the synthesis of inflammatory mediators such as prostaglandins and thromboxanes, thereby reducing inflammatory responses.
Regulate immune cell function: Studies have shown that bromelain can regulate the function of immune cells (such as T cells and B cells) and affect the initiation and resolution of inflammatory responses.
Lowering cytokine levels: Bromelain can reduce the levels of proinflammatory cytokines (such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)) and reduce inflammatory responses.

3. Other possible mechanisms:
Antioxidant effect: Bromelain itself may have certain antioxidant activity, or indirectly play an antioxidant role by increasing the activity of antioxidant enzymes in the body, reducing oxidative stress damage.
Immunomodulatory effect: In addition to regulating inflammatory responses, bromelain may also have a broader immunomodulatory effect, affecting the balance and function of the immune system.
Enhancing drug absorption: Some studies have shown that bromelain may enhance the absorption of certain drugs, such as antibiotics, thereby improving the efficacy of drugs.

Application of Bromelain powder

1. Dietary supplements: This is the main application area. Bromelain supplements are often used to relieve inflammation, joint pain, promote digestion, support the immune system, etc.

2. Food industry:
Meat tenderizer: Using its proteolytic activity, it can tenderize meat and improve the taste of meat.
Beer brewing: Used in the beer production process to help decompose protein and improve the clarity and stability of beer.
Baking industry: Used for dough improvement to improve the extensibility and processing properties of dough.

3. Cosmetics industry:
Exfoliant: Bromelain can decompose keratin on the surface of the skin, has a mild exfoliating effect, and is used in products such as facial masks and scrubs.
Anti-inflammatory soothing ingredients: Used in skin care products to play an anti-inflammatory, soothing, and calming role.

4. Medical field:
Prescription drugs (for external use): Bromelain topical preparations have been approved for the treatment of burns.
Over-the-counter (OTC) drugs: OTC drugs containing bromelain are often used to relieve inflammation and pain caused by sinusitis, sprains, strains, etc.

5. Enzyme preparations: Bromelain can be used as an enzyme preparation in in vitro diagnostic reagents, biotechnology research and other fields

Doses of Bromelain powder

Dietary supplements (capsules, tablets, powders): used for anti-inflammatory, analgesic, digestive and other purposes, the common dosage range is 500mg to 2000mg per day, taken in divided doses. The specific dosage should refer to the product instructions and consult the doctor or pharmacist for advice. The dosage is usually measured in enzyme activity units (GDU or MCU) rather than simple milligrams. For example, for bromelain with an activity of 2400 GDU/g, a dose of 500mg is equivalent to an enzyme activity of 1200 GDU.

Topical creams and ointments: used for wound healing, inflammation relief and other purposes, apply topically to the affected area according to the product instructions, usually 1-3 times a day.

Food processing: used for meat tenderization, beer brewing, etc., added according to the specific food processing technology and needs

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