Cosmetic Grade Ethyl 3-methyl-3-phenylglycidate liquid CAS 77-83-8

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Uses and synthesis of Ethyl 3-methyl-3-phenylglycidate liquid

Ethyl 3-methyl-3-phenylglycidate liquid colorless to light yellow liquid. Insoluble in water, soluble in organic solvents such as ethanol. Ethyl 3-methyl-3-phenylglycidate was obtained from the Darzens reaction of acetophenone with ethyl chloroacetate catalyzed by sodium ethanolate. Ethyl 3-methyl-3-phenylglycidate is used in the preparation of strawberry, cherry and apple flavor. For hyacinth, lilac, rose and other flower flavor and lipstick flavor, for strawberry, raspberry and other berry flavor.

Applications/Functions of Ethyl 3-methyl-3-phenylglycidate liquid

• Ethyl 3-methyl-3-phenylglycidate liquid is used to prepare daily chemical flavor and feed flavor
• It has the function of enhancing aroma in daily flavor and is often used in food flavor
• Ethyl 3-methyl-3-phenylglycidate has a strong aroma of poplar and is usually used as a blend of bayberry flavors when diluted. It is also used in cosmetics. A small amount of ethyl 3-methyl-3-Phenylglycidate is used to produce a special effect when mixing cosmetic flower extracts such as rose, hyacinth and cycleen.

Application of Ethyl 3-methyl-3-phenylglycidate liquid

1. Chiral synthetic intermediates: Because its molecules contain epoxy rings and ester groups, as well as potential chiral centers, it becomes an important precursor for the synthesis of a variety of chiral compounds.

Synthetic drug intermediates: It can be used as a key intermediate for the synthesis of a variety of drugs, for example:

β-receptor blockers: The amino alcohol chain can be introduced through the ring-opening reaction of the epoxy ring to synthesize biologically active β-receptor blocker drugs.

Antihypertensive drugs: For example, 3-methyl-3-phenyl glycidyl propionate can be converted into a key intermediate for angiotensin-converting enzyme inhibitors (ACEI) drugs through a specific reaction route.

Antifungal drugs: For example, 3-methyl-3-phenyl glycidyl propionate may also be used as an intermediate in the synthesis of certain azole antifungal drugs.

Other chiral drug intermediates: It can be used to synthesize other chiral compounds with important biological activities, such as antiviral drugs, antitumor drugs, nervous system drugs, etc.
Synthetic natural products and fine chemicals: It can be used as a key intermediate for the synthesis of fine chemicals such as natural products, fragrances, liquid crystal materials, polymer materials, etc.

2. Preparation of ethylene oxide derivatives: It can be used as a precursor for the preparation of other ethylene oxide derivatives. Through the ring-opening reaction of the epoxide ring, different functional groups are introduced to synthesize ethylene oxide derivatives with diverse structures for further synthetic transformation.

3. Polymerization reaction monomer: It can be used as a monomer for polymerization reaction, participate in the ring-opening polymerization reaction, and synthesize polymer materials with specific functions.

4. Scientific research reagents: In the research fields of organic synthetic chemistry, medicinal chemistry, materials chemistry, etc., it is used as an important research reagent for the exploration of new synthetic methods, the development of new materials, and the research of bioactive molecules.

Physical properties of Ethyl 3-methyl-3-phenylglycidate liquid

It is usually liquid or low melting point solid at normal temperature and pressure, and its color is colorless to light yellow.
It has a certain aromatic smell.
It is insoluble in water, but soluble in common organic solvents such as ethanol, ether, dichloromethane, dimethyl sulfoxide (DMSO), etc.
The specific melting point, boiling point, density, refractive index and other physical property data may vary slightly due to the specific isomer (cis-trans isomer) ratio, and it is necessary to refer to the analysis report or literature data of the specific product.

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