Glycyrrhetinic Acid powder Raw Materials CAS 471-53-4
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Uses and synthesis of Glycyrrhetinic Acid powder
Glycyrrhetinic Acid powder A white crystalline powder with a sweet taste and a sweetness about 200 times that of sucrose. Its sweetness is different from sugar and other sweeteners, and it has a sweet feeling after a short while after the entrance, but it lasts a long time. A small amount of liquiritin combined with sucrose can use 20% less sucrose without the same sweetness. Although it has no aroma, it has the effect of enhancing aroma. Melting point (decomposition)220℃. The aqueous solution is weakly acidic and can be acted by acid. Glycyrrhetinic Acid is formed when glycyrrhizin water unshackles the acid chain and is 250 times sweeter than sucrose. Glycyrrhetinic Acid is cytotoxic, and prolonged consumption of glycyrrhetinic acid (100g/d) can lead to severe hypertension and cardiac hypertrophy, with clinical symptoms of sodium retention and potassium excretion, and in severe cases, extreme weakness and ventricular fibrillation.
Applications and Functions of Glycyrrhetinic Acid powder
1. Traditional medical application: In traditional Chinese medicine and Indian Ayurvedic medicine, licorice root and its extracts (including glycyrrhizic acid) are widely used to treat a variety of diseases, including:
Respiratory diseases such as cough, sputum, sore throat, etc.
Digestive system diseases such as stomachache and gastric ulcer.
Liver diseases such as hepatitis and jaundice.
Skin diseases such as skin inflammation, eczema, dermatitis, etc.
2. Modern medical application: Modern medical research has also confirmed the various pharmacological activities of glycyrrhizic acid, and a variety of glycyrrhizic acid preparations have been developed, mainly used for:
Liver disease treatment:
Glycyrrhizic acid and its salt preparations, such as diammonium glycyrrhizinate injection, monoammonium glycyrrhizinate capsules, compound glycyrrhizic acid glycoside tablets, etc., are widely used to treat chronic hepatitis, drug-induced liver injury, fatty liver and other liver diseases, and have the effects of protecting liver and reducing enzymes, anti-inflammatory and anti-fibrosis. It is a commonly used liver protection drug in clinical practice.
Skin disease treatment: Glycyrrhetinic acid and its derivatives are added to topical skin preparations for the treatment of inflammatory skin diseases such as eczema, dermatitis, and urticaria. They have anti-inflammatory and antipruritic effects, and promote skin repair. They are also commonly used in cosmetics as an anti-inflammatory and soothing ingredient.
Oral ulcer treatment: Glycyrrhetinic acid mouthwash or lozenges are used to treat oral inflammation such as oral ulcers and gingivitis. They have anti-inflammatory and analgesic effects and promote ulcer healing.
Antiviral drug development (research stage): Due to the antiviral activity of glycyrrhetinic acid, researchers are exploring the possibility of developing it into an antiviral drug, especially for herpes virus, influenza virus, hepatitis virus, etc.
3. Dietary supplements (health products): Glycyrrhetinic acid is also sold in the form of dietary supplements, claiming to have immune-enhancing, anti-oxidant, and liver-protecting effects, but the scientific evidence for its health benefits is relatively limited, and potential side effects need to be noted.
Physicochemical Property of Glycyrrhetinic Acid powder
Glycyrrhetinic Acid An glycoside composed of glycyrrhizin-FF two molecules of glucuronic acid. White crystalline powder, sweet taste, sweetness is about 200 times that of sucrose. Its sweetness is different from sugar and other sweeteners, and it has a sweet feeling after a short while after the entrance, but it lasts a long time.
Production methodprocess of Glycyrrhetinic Acid powder
Glycyrrhetinic Acid powder is prepared by hydrolysis of Glycyrrhiza uralen-sis fisch, which is extracted from the rhizomes of the leguminous plant.
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