beta-Nicotinamide Mononucleotide Powder Raw Materials CAS 1094-61-7

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Uses and synthesis of beta-Nicotinamide Mononucleotide Powder

beta-Nicotinamide Mononucleotide Raw Materials, also known as beta-Nicotinamide Mononucleotide (NMN), is a substrate for the synthesis of Coenzyme I. NMN has also been used in anti-aging research.

Studies have shown that beta-Nicotinamide Mononucleotide CAS 1094-61-7 can also regulate insulin secretion and have an effect on the expression level of mRNA, and beta-NMN has a wide range of applications in the field of medical therapeutics. beta-Nicotinamide Mononucleotide Powder is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate.

beta-Nicotinamide Mononucleotide Powder improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression associated with oxidative stress, inflammatory responses and circadian rhythms, in part through SIRT1 activation.

Applications / Functions of beta-Nicotinamide Mononucleotide Powder

1. In mammals, beta-Nicotinamide Mononucleotide CAS 1094-61-7 is produced from nicotinamide (Nam) catalyzed by Nampt (a protease in vivo), followed by nicotinamide mononucleotide catalyzed by nicotinamide mononucleotide adenylyltransferase to produce NAD+.
2. beta-Nicotinamide Mononucleotide Raw Materials is a direct way to supplement NAD+.
3. Nicotinamide Mononucleotide is responsible for reversing the effects of aging by dramatically increasing the ability of cells to repair DNA damage. beta-Nicotinamide Mononucleotide Powder is converted into "Nicotinamide Adenine Dinucleotide (NAD)", a substance essential for energy metabolism in the body. NAD" substance, which is essential for energy metabolism in the body.
4. In mouse tests, it was shown that nicotinamide mononucleotide activates a gene called acetylase in the body, which has been shown to be effective in prolonging life and treating diabetes, etc. NAD is a substance that can be produced by the human body, and it has been shown that the amount of NAD in the body decreases with age.

Physicochemical Property of beta-Nicotinamide Mononucleotide Powder

Appearance of beta-Nicotinamide Mononucleotide Powder is white to slightly yellowish, crystalline powder, no obvious odor.

Production methodprocess of beta-Nicotinamide Mononucleotide Powder

Add 150 ml of phosphate buffer solution into a 500 ml four-necked bottle. 2g of MgCl2, 10g of ATP, 7g of ribose, 10g of nicotinamide were added at once and stirred at 35℃. The pH of the reaction system was detected and pH = 8.0 was adjusted with 10% Na2CO3 solution, then 1 g of RK enzyme powder and 2 g of NAMPT enzyme powder were added and stirred to dissolve.

The reaction was stirred at 200 rpm at 37 °C, and the conversion rate of the reaction was monitored using liquid chromatography-mass spectrometry, and after 6 h of reaction, the reaction was stopped by detecting that ATP had been consumed.

The beta-Nicotinamide Mononucleotide Raw Materials can be obtained by further filtration, adsorption on HZ-818-type macroporous resin, lyophilization, and recrystallization from ethanol and water , with 70% yield.

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