Kojic acid Powder Raw Materials CAS 501-30-4

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Uses and synthesis of Kojic acid Powder

Kojic acid Powder, also known as kojic acid and kojic acid, is an organic acid with antimicrobial effect produced by the aerobic fermentation of glucose by Candida Aspergillus at 30-32°C. The molecular structure of Kojic acid is a γ-pyrone with substituent groups, and Kojic acid CAS 501-30-4 is a well-known compound among the γ-pyrone compounds existing in nature, which is only kojic acid and maltol.

In 1907, Saito crystallized Kojic acid Raw Materials from rice crackers, which was named by Yabuta in 1912, and the structure of Kojic acid CAS 501-30-4 was determined in 1924, and isotope tracing techniques were applied to Kojic acid by Arnstela in 1953 (surface fermentation) and by Makio Kitada in 1971 (deep fermentation) to prove that Kojic acid is glucose without carbon dioxide.

Kojic acid Powder

In 1953, Arnstela (surface fermentation) and in 1971, Makio Kitada (deep fermentation) used isotope tracing techniques to show that kojic acid is formed from glucose by oxidizing and dehydrating glucose without breaking the carbon framework.

Applications / Functions of Kojic Acid Powder

Kojic acid CAS 501-30-4 is used in cosmetics, food additives and pharmaceuticals.
Tyrosinase inhibitor; food antioxidant
Kojic acid Powder Used as a reagent for quantitative analysis of trivalent iron. Tyrosinase inhibitor. Kojic acid is a melanin exclusive inhibitor, it enters the skin cells can be complexed with the copper ions in the cell, change the stereo structure of tyrosinase, prevent the activation of tyrosinase, thus inhibiting the formation of melanin. It is present in the culture medium of Aspergillus (Aspergillus) used for brewing. Produced by aerobic fermentation with Aspergillus oryzae. Used as a flavor enhancer.

Physicochemical Property of Kojic acid Powder

Kojic Acid Raw Materials Crystals are prismatic, acicular and colorless. Kojic acid is soluble in water, alcohol, acetone, slightly soluble in ether, ethyl acetate, chloroform, pyridine, insoluble in most other solvents.Kojic Acid Raw Materials can be purified by crystallization in solvents such as acetone, ethyl acetate, and can also be sublimated under reduced pressure at 150~200℃.

Kojic acid Powder is not stable to light and heat, the concentration of 0.5% of the solution of Kojic acid in different pH 100 ℃ treatment for 3h or sunlight irradiation for 5h, the result in the range of pH5 ~ 7 solution becomes yellowish ~ yellowish brown, while in the pH4 is not much change.Kojic acid CAS 501-30-4 has a special red color with ferric chloride, and can be quantified by this method.

Kojic acid Raw Materials can reduce Ferrin's reagent and silver ammonia nitrate, there is an alcohol hydroxyl group near the carbonyl group in its molecular structure, which can generate salts with many metals, and other hydroxyl groups can generate ether and ester derivatives.

Production methodprocess of Kojic acid Powder

Kojic acid Powder can be used as an iron reagent. Even with stainless steel fermenters, the fermentation broth is reddish-brown in color, a property that affects the extraction and refining process.

Kojic acid Raw Materials

Kojic acid CAS 501-30-4 has been extracted from fermentation broth by copper salt precipitation method, ethyl acetate extraction method, ether continuous extraction method, concentration and crystallization or freeze crystallization method, etc. In the 1970s, zinc salt method was used in Beijing Nihon Chemistry No.1 Factory.

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