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Uses and synthesis of DL-α-Tocopherol Powder

DL-α-Tocopherol Powder is chemically known as (±)-2,5,7,8-tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, also known as vitamin E alcohol, and is a class of compounds that primarily exhibit vitamin E activity. DL-alpha-Tocopherol Powder was named "tocopherol" because its vitamin activity was first identified in 1936 in an experiment on the factor of fertility in rats.

DL-α-Tocopherol Powder is found in cooking oils, fruits, vegetables and grains, and is a fat-soluble vitamin and an important antioxidant. dL-α-Tocopherol CAS 10191-41-0's analogues are: d-α-tocopherol; d-α-tocopherol ester; dl-α-tocopherol ester; d-α-tocopherol ester with hydrogensuccinate; hydrogen succinate d-α-tocopherol ester; hydrogen succinate d-α-tocopherol ester; hydrogen succinate d-alpha tocopherol ester; hydrogen succinate d-alpha tocopherol ester. 

DL-α-Tocopherol Raw Materials, i.e. Vitamin E, is the name of western medicine. Common dosage forms are tablets, capsules, and injections. It is used for habitual abortion, preeclampsia, infertility and menopausal disorders; progressive muscular dystrophy, vulvovaginal atrophy and vulvovaginal pruritus, hemolytic anemia of preterm infants, calf cramps, intermittent claudication and so on.

Applications / Functions of DL-α-Tocopherol Powder

• 1、DL-α-Tocopherol Powder is a highly effective antioxidant, which can protect cell membranes from free radicals, and protect blood vessels, heart, breast, eyes, skin and glands and other organs. Thus, it can prevent many chronic diseases. Such as breast cancer, cardiovascular disease, rectal cancer and so on.
• 2、DL-α-Tocopherol Raw Materials promotes protein renewal and synthesis, and can promote wound healing.
• 3、DL-α-Tocopherol Raw Materials promotes the proliferation of capillaries and small blood vessels, and improves peripheral blood circulation, increasing the supply of oxygen in the tissues, thus creating good nutritional conditions for the healing of ulcer surfaces.
• 4、DL-α-Tocopherol CAS 10191-41-0 is related to reproductive function and spermatogenesis, preventing miscarriage, infertility and maintaining ovaries.
• 5、DL-α-Tocopherol Powder Protect red cell membrane, prevent hemolytic anemia.
• 6、DL-α-Tocopherol CAS 10191-41-0 whitening and blemish removal, hair care, sunscreen and skin care.
• 7、DL-α-Tocopherol Raw Materials Improve immune function and delay aging.
• 8, DL-α-Tocopherol CAS 10191-41-0 inhibit the growth of Helicobacter pylori, so that the recurrence rate of ulcer disease after healing is reduced.
• 9、DL-α-Tocopherol Powder Oxygen agent, protect cells from oxidative stress or damage.
• 10, DL-α-Tocopherol CAS 10191-41-0 has been used in the preparation of mycobacteria emulsion, has also been used in the influenza virus infection, the study of immunomodulatory effects

DL-α-Tocopherol Powder properties and stability

DL-α-Tocopherol Powder is a fat-soluble vitamin, also known as tocopherol or haematopoietin, belongs to the phenolic compounds, is one of the most important antioxidants, with antioxidant, promote the renewal of protein synthesis, the regulation of platelet adhesion and aggregation of the role of the adult nutritional supplementation of vitamins, the daily reference dosage of vitamin: vitamin A is 1.5mg; Vitamin E is 30mg. Vitamin A is 1.5mg; Vitamin E is 30mg.

Natural vitamin E has a variety of structural differences only in the side chain R1, R2, and R3, in cooking oil, fruits, vegetables and grains are present in 1988, the success of artificial synthesis, can maintain the normal function of the reproductive organs, the body's metabolism has a good effect, can make the ovary weight Scrooge, to promote its function, to promote the maturation of follicles, so that the luteal body to increase, and can inhibit progesterone oxidation in the whole, thus Increase the effect of progesterone.

DL-α-Tocopherol CAS 10191-41-0 has auxiliary therapeutic effect on excessive menstruation, vulvar itching, nocturnal calf cramps, hemorrhoidal disorders. In recent years, vitamin E is also widely used in anti-aging, it is believed that it can eliminate the deposition of lipofuscin in the cells, improve the normal function of the cells, slow down the aging process of tissue cells.

Production method of DL-α-Tocopherol Powder

DL-α-Tocopherol CAS 10191-41-0 is produced from 1,2,4-trimethylbenzene by iodination, nitration, reduction and oxidation to obtain 2,3,5-trimethylbenzoquinone, and then reduced and condensed with chlorophyllin.

A 100 ml round-bottomed flask equipped with a Dean-Stark device and a condenser was purged with nitrogen, after which 6.24 g (0.041 mol) of TMHQ, 4.16 g of silica gel, and 2.08 g (0.015 mol) of ZnCl2 were added, followed by the addition of 134 ml of n-heptane and stirring of the solution. The flask was equipped with a dropping funnel through which nitrogen was blown into the flask. To this dropping funnel was added a solution of 12.48 g (0.042 mole) of isophytol in 10 ml of n-heptane, and the flask was heated to reflux in a nitrogen atmosphere. While refluxing, the solution of isophytol in n-heptane was slowly added to the flask through this dropping funnel over a period of 1 hour. At the end of the dropwise addition, the reaction was allowed to proceed under reflux conditions for another 2 hours. The product mixture was analyzed by GC to give a conversion of 96.9% for TMHQ and a purity of 99.1% for DL-α-tocopherol.

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