Factory Supply L-Glutathione Powder CAS 27025-41-8 Raw Materials

MF:C20H32N6O12S2

MW: 612.63

EINECS:248-170-7

Specification:L-Glutathione Powder

Sample:L-Glutathione Powder

Brand: L-Glutathione Powder

Appearance: White Powder

Storage: Cool Dry Place

Brand: Globalchemical

Shelf Life: 2 Years

Test Method: HPLC

Uses and synthesis of L-Glutathione Powder

L-Glutathione Powder is a tripeptide containing sulfhydryl groups bound to glutamic acid, cysteine and glycine, which has antioxidant and integrative detoxification effects. The sulfhydryl group on cysteine is the active group of glutathione (so glutathione is often abbreviated as G-SH), which is easy to bind with certain drugs (such as paracetamol), toxins (such as free radicals, iodoacetic acid, mustard gas, lead, mercury, arsenic and other heavy metals), etc., and has an integrated detoxification effect. L-Glutathione CAS 27025-41-8 (especially glutathione in liver cells) can participate in biotransformation, thus converting harmful toxicants into harmless substances and excreting them out of the body.L-Glutathione CAS 27025-41-8 can also help to maintain normal immune system function.

L-Glutathione Raw Materials is available in both reduced (G-SH) and oxidized (G-S-S-G) forms, with reduced glutathione predominating under physiological conditions.L-Glutathione Powder reductase catalyzes the interconversion between the two types. The coenzyme of the enzyme is NADPH, which is supplied by phosphate bypass metabolism.

Applications / Functions of L-Glutathione Powder

• 1, L-Glutathione CAS 27025-41-8 can play a reducing role when added to pasta products. It can not only shorten the time of bread making to one half or one third of the original one, but also improve the labor conditions greatly, and strengthen the nutrition of food and other functions.
• 2、Add L-Glutathione Powder to yogurt and baby food, equivalent to vitamin C, can play the role of stabilizer.
• 3、Mix L-Glutathione CAS 27025-41-8 into fish cake, it can prevent the color from deepening.
• 4、L-Glutathione Raw Materials is added to meat products and cheese and other foods, with the effect of strengthening the flavor.

L-Glutathione Raw Materials has a broad-spectrum detoxification effect, not only can be used in drugs, but also as a base material for functional foods, widely used in functional foods such as aging, immunity enhancement, anti-tumor and so on.

Glutathione drugs have been artificially developed and widely used in clinics. In addition to the use of its sulfhydryl group to chelate heavy metals, fluoride, mustard gas and other toxin poisoning, L-Glutathione Powder is also used in hepatitis, hemolytic diseases, and corneal inflammation, cataracts, and retinal diseases as a therapeutic or adjunctive treatment drugs. In recent years, Western scientists, especially Japanese scholars, have discovered that glutathione has the function of inhibiting HIV.

The latest research also shows that GSH can correct the imbalance of acetylcholine and cholinesterase, play the role of anti-allergy, and also prevent skin aging and pigmentation, reduce the formation of melanin, improve the antioxidant capacity of the skin and make the skin produce luster. In addition, GSH has a very good role in the treatment of keratoconus disease and improvement of sexual function.

L-Glutathione Raw Materials with Vitamin C

In addition, vitamin C is an important antioxidant in the body. Since vitamin C can be reversibly hydrogenated or dehydrogenated, vitamin C plays an important role in many redox reactions in the body. For example, the active group of many enzymes is sulfhydryl (-SH), vitamin C can maintain -SH in a reduced state and maintain enzyme activity; vitamin C can make oxidized glutathione into reduced glutathione (GSH), so that the body metabolism of hydrogen peroxide (H2O2) reduction; vitamin C can also protect vitamin A, E and some B vitamins from oxidation. Therefore, the use of glutathione with vitamin C can improve the efficacy of L-Glutathione Powder.

L-Glutathione Powder properties and stability

L-Glutathione CAS 27025-41-8 has a relative molecular weight of 307.33, melting point of 189~193°C, colorless and transparent crystals in the form of long columns, isoelectric point of 2.83. L-Glutathione CAS 27025-41-8 is readily soluble in water, soluble in dilute alcohols, liquid ammonia, insoluble in alcohols, ethers and acetone. It is widely distributed in animals, plants and oil seeds. One of its functions in cells is to protect against various toxins and carcinogens.

Studies have shown that L-Glutathione Powder is completely absorbed in the small intestine and that certain epithelial cells can utilize exogenous glutathione for detoxification, suggesting that dietary glutathione determines the degree of cellular protection from damage in the body. In addition to its role as an antitoxin, L-Glutathione Raw Materials also has an activating effect on some sulfhydryl enzymes, and can be used as an antioxidant that protects enzymes and other protein sulfhydryl groups, and plays a role in biological oxidation, amino acid transport, and protection of hemoglobin. In addition, L-Glutathione Raw Materials also inhibits aging, prevents diabetes, eliminates fatigue and other effects. Glutathione has health effects on human body while enhancing the flavor of food, and the application prospect of L-Glutathione CAS 27025-41-8 is obviously better than other types of antioxidants and preservatives. Recently, it has also been found that glutathione has the effect of inhibiting AIDS. Therefore, the study of L-Glutathione Powder is of great significance to human health and life.

Production method of L-Glutathione Powder

A production method of high purity L-Glutathione Powder, characterized in that the method comprises the following steps:

• (1) Centrifugation of fermentation broth: The glutathione fermentation broth with a fermentation level of at least 1650 mg/L was centrifuged after going down the tank, and the centrifugation speed was 3,000~5,000 rpm, and the time was 5~lOmin, to obtain a wet yeast cell body;
• (2) Hot water wall-breaking: add 1 part of wet yeast cell body to 6~10 parts of boiling water in the extraction tank, stirring, stirring speed of 300~350rpm, when the temperature of the extracted liquid reaches 85~95°C, hold for 10~15minutes, stop the extraction, pour out the extracted liquid, and cool the extracted liquid to room temperature in a water bath;
• (3) Centrifugation of extract: centrifuge the extract at 3000~5000rpm for 5~l0min, remove the yeast residue, and obtain the extract containing GSH;
• (4) pH adjustment: Add acid into the extract after centrifugation to keep the material system in an acidic environment of pH 2.5~3.5, which can precipitate some impurities and keep GSH in a stable state to prevent oxidation;
• (5) Microfiltration: use 0.1 ~ 1 μ m pore size microfiltration equipment to adjust the pH of the extracted solution for filtration, in order to remove small particles of suspended impurities, to get a clear and transparent filtrate;
• (6) Cation resin separation: the material liquid after microfiltration is adsorbed on sulfonic acid group cation resin in acidic environment, so that GSH is adsorbed, and then resolved with sodium chloride or hydrochloric acid solution to obtain GSH-rich liquid;
• (7) Adsorption resin separation: the GSH-rich liquid after separation and purification by cation exchange resin is adsorbed again on styrene-based weakly polar macroporous adsorption resin, and then eluted with pure water to obtain GSH liquid with high purity;
• (8) Decompression concentration: Concentrate the GSH solution under vacuum of -0.07~-0.098Mpa and temperature of 55~65°C under decompression, so as to achieve a GSH content of more than 400mg/ml;
• (9) Crystallization: Add isopropyl alcohol or ethanol to the glutathione concentrate to make the organic solvent content reach 60%~80%, adjust the pH value to 2.90~3.0, and crystallize at 0~4°C;
• (10) Wash the crystals: wash the crystals with acetone solution with a concentration of 70% to 90% by volume;