Factory Supply Creatine Powder CAS 57-00-1 Raw Materials

MF:C4H9N3O2

MW:131.13

EINECS:200-306-6

Specification:Creatine Powder

Sample:Creatine Powder

Brand: Creatine Powder

Appearance: White Powder

Storage: Cool Dry Place

Brand: Globalchemical

Shelf Life: 2 Years

Test Method: HPLC

Uses and synthesis of Creatine Powder

Creatine Raw Materials, also known as alpha-methylguanidinoacetic acid, is a natural nutrient found in the human body, and can also be synthesized from arginine, glycine and methionine in the liver, kidney, and pancreas: catalyzed by renal arginine-glycine amidinotransferase, the amidinothionic group of arginine is transferred to the amino group of glycine to form guanidinoacetic acid. Then in the liver, catalyzed by guanidinoacetic acid methyltransferase, the methyl group of S-adenosylmethionine is transferred to guanidinoacetic acid to produce Creatine Powder.

Creatine Powder, in biochemistry, is a nitrogen-containing organic acid that occurs naturally in vertebrates and aids in energizing muscle and nerve cells. Michel Eugène Chevreul first discovered creatine in skeletal muscle in 1832 and later named it Creatine CAS 57-00-1 after the Greek word "Kreas" (meat).

Creatine CAS 57-00-1 can quickly provide energy (the human body relies on ATP, or adenosine triphosphate, to provide energy for its activities, but ATP storage in the body is very small, and when exercising, ATP is quickly depleted, and then Creatine Powder is able to quickly re-synthesize ATP to provide energy). The storage capacity of adenosine triphosphate in the human body is very small, and it needs to be synthesized continuously, but the synthesis speed of the body is very slow, so the muscle body causes fatigue. Therefore, timely supplementation of Creatine Raw Materials can effectively improve muscle strength, speed and endurance. It improves fitness and training levels and prevents fatigue.

Applications / Functions of Creatine Powder

Creatine Powder has the basic functions of increasing the water content of muscle cells, helping muscle cells to store energy, increasing protein synthesis, etc. Among them, the synthetic Creatine CAS 57-00-1 can be used to promote the adaptation of bone and armour muscles to strenuous exercise and to fight against excessive fatigue in weak individuals as a nutritional supplement; Creatine CAS 57-00-1 can also be used for the preparation of the treatment of heart disease and respiratory function. Creatine CAS 57-00-1 can also be used in the preparation of drugs for the treatment of heart disease and respiratory insufficiency; the preparation of pharmaceutical preparations containing human growth hormone; and can be used in the compounding of a new kind of health food, which has the effect of anti-aging and restoring physical strength.

• 1.Creatine Raw Materials can be used as nutritional supplements to promote the adaptation of bone and armour muscles to strenuous exercise and to counteract excessive fatigue in weakened individuals.
• 2.Creatine Powder can be used in the preparation of drugs for the treatment of heart disease and respiratory insufficiency.
• 3.Preparation of pharmaceutical preparations containing human growth hormone.
• 4.Creatine CAS 57-00-1 can be used to formulate a new health food with anti-aging and physical strength restoration effects.
• 5.Creatine Raw Materials are used as reagents for biochemical research.

Creatine Powder is used in biochemical research.

Creatine Powder properties and stability

Creatine Powder is prismatic crystal (containing one molecule of water of crystallization). Melting point 303°C, relative density 1.33, soluble in boiling water and 98% acetic acid, slightly soluble in ethanol, insoluble in ether and butyric acid. With inorganic acids to creatinine, and soda lime coheating to methylamine, and potassium hydroxide azeotropy to ammonia, and potassium permanganate to methylguanidine oxalate and guanidine; in aqueous solution at room temperature with mercury acetate to methylguanidine acetaldehyde acid, and finally produce methylguanidine and oxalic acid. It is converted to creatinine in the autodigestive action of muscle juice or organ extracts.

Production methodprocess of Creatine Powder

1.There are three different process routes for the preparation of Creatine Powder from lime nitrogen:

• (1) Lime nitrogen reacts with aqueous sodium sarcosinate to produce Creatine Raw Materials directly.
• (2) Lime nitrogen reacts with a methanol solution saturated with dry hydrogen chloride gas to obtain O-methylisourea hydrochloride, and O-methylisourea hydrochloride then reacts with sarcosine to obtain Creatine Powder.
• (3) Lime nitrogen and aqueous hydrochloric acid solution under the condition of passing air to form chloroformamidine chloride, and then react with sodium sarcosinate to obtain Creatine CAS 57-00-1.

The method was as follows: add 3.3 mol of urea and 6 mL of 50% H2SO4 to a 500 mL four-necked flask equipped with a stirrer, a thermometer, a dropping funnel and a condenser, heat it up to 40 ℃, and add 3 mol of dimethyl sulfate dropwise with stirring for 3 h. During the charging period, the temperature was controlled at 70 ℃ or less, and after finishing the charging period, it was stirred at 70 ℃ or so for 2 h, and then cooled down to obtain 561.8 g of O- methylisourea sulfate. In a 500 mL four-necked flask equipped with a stirrer, thermometer, dropping funnel and condenser, 61.7 g of 36% sodium sarcosinate aqueous solution was added, and the pH was adjusted to about 11.0 with 30% HCl, and then 50.0 g of O-methylisourea sulfate was added dropwise at 20 ℃ for 2 h. During the process of addition, the pH was adjusted with 25% NaOH solution to keep it at about 11.0, and then the dropwise addition was completed. After the dropwise addition, the mixture was continued to be stirred at 40°C for 2h, and then cooled at 0~5°C for 2h, and the colorless crystals formed were filtered out. The filter cake was washed with 2×15mL ice water to obtain the crude product of creatine monohydrate. Put the crude product into a beaker, add 7-8 times the amount of the crude product to water, heat until all dissolved, cool the liquid slowly at room temperature, crystallize, filter out the crystals, and then dry at 50 ℃ to obtain Creatine CAS 57-00-1.