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  • Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials

    • Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials
    • Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials
    • Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials
    • Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials workshop
    • Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials factory
    • Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials

    Product Overview:

    R)-(+)-Lipoic Acid Powder, also known as dextro-lipoic acid, is a white or yellowish, odorless, powdery or crystalline substance commonly used in vitamin medications for the treatment of chronic hepatitis, psoriasis, and erythematous lupus.

    R)-(+)-Lipoic acid CAS 1200-22- is a yellow crystalline substance. Lipoic acid is a biologically active natural product.In 1951 Raed et al. reported the isolation of a crystalline cofactor for growth-promoting enzymes from treated insoluble liver tissue residue.The compound was named Lipoic acid because of its highly fat-soluble and acidic nature (pka = 4.7).
    The two enantiomers of Lipoic acid show different biological activities. Among them, the R-type enantiomeric isomer was more effective than the S-type, which may be due to the fact that during the metabolism of lipoic acid, a large amount of R-type lipoic acid could enter the cell and mitochondria through the cell membrane and mitochondrial membrane to be reduced to dihydrolipoic acid while only a small amount of the S-type entered into the cell and was reduced. Dihydrolipoic acid has a stronger antioxidant capacity than lipoic acid, and the regeneration of endogenous antioxidants and the repair of oxidative damage can only be realized through the form of dihydrolipoic acid.

    Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials Attributes

    CAS: 1200-22-2

    MF:C8H14O2S2
    R)-(+)-Lipoic acid Powder

    MW:206.33

    EINECS:638-752-2

    Specification:R)-(+)-Lipoic acid Powder

    Sample:R)-(+)-Lipoic acid Powder

    Brand: R)-(+)-Lipoic acid Powder

    Appearance: Yellow Powder

    Storage: Cool Dry Place

    Brand: Globalchemical

    Shelf Life: 2 Years

    Test Method: HPLC

    Factory Supply R)-(+)-Lipoic acid Powder CAS 1200-22-2 Raw Materials Details

    Uses and synthesis of R)-(+)-Lipoic acid Powder

    R)-(+)-Lipoic Acid Powder, also known as dextro-lipoic acid, is a white or yellowish, odorless, powdery or crystalline substance commonly used in vitamin drugs for the treatment of chronic hepatitis, psoriasis, and erythematous lupus.

    R)-(+)-Lipoic acid Raw Materials

    R)-(+)-Lipoic acid CAS 1200-22-2 is a yellow crystalline substance. Lipoic acid is a biologically active natural product.In 1951 Raed et al. reported the isolation of a crystalline cofactor for growth-promoting enzymes from treated insoluble liver tissue residue.The compound was named Lipoic acid because of its highly fat-soluble and acidic nature (pka = 4.7).

    The two enantiomers of Lipoic acid show different biological activities. Among them, the R-type enantiomeric isomer was more effective than the S-type, which may be due to the fact that during the metabolism of lipoic acid, a large amount of R-type lipoic acid could enter the cell and mitochondria through the cell membrane and mitochondrial membrane to be reduced to dihydrolipoic acid while only a small amount of the S-type entered into the cell and was reduced. Dihydrolipoic acid has a stronger antioxidant capacity than lipoic acid, and the regeneration of endogenous antioxidants and the repair of oxidative damage can only be realized through the form of dihydrolipoic acid.

    Applications / Functions of R)-(+)-Lipoic Acid Powder

    R)-(+)-Lipoic Acid Raw Materials are used in acute and chronic hepatitis, cirrhosis of the liver, hepatic coma, fatty liver, diabetes mellitus, human acquired immune deficiency carriers, AIDS, psoriasis, eczema, burns, skin cancer, multiple sclerosis, Parkinson's disease, neurological disorders, rheumatism, rheumatic arthritis, lupus erythematosus, scleroderma, autoderma. Rheumatism, rheumatoid arthritis, erythematous lupus, scleroderma, autoimmune diseases, cataracts, other ophthalmologic diseases, heart disease, stroke, arteriosclerosis, acute and chronic hepatitis, hepatic cirrhosis, hepatic coma, fatty liver disease, and other diseases of the treatment and efficacy of health care.

    R)-(+)-Lipoic acid Powder

    At present, its dietary supplement products include powder, mixture, tablet, hard gelatin capsule, soft gelatin capsule, and R)-(+)-Lipoic acid Powder can also be applied to beverages, confectionery, bread, dairy products and other functional foods. In order to better manufacture different varieties of dietary supplement products and to better apply ALA in the manufacture of different types of functional foods, it must be stored above 40°C and protected from light (UV).

    R)-(+)-Lipoic acid CAS 1200-22-2 Vitamin drugs, better than lipoic acid.

    Physicochemical Property of R)-(+)-Lipoic acid Powder

    Appearance:White or light yellow, odorless powder/crystal.

    Spin: +104°(c=0.88, benzene, 23℃)

    Solubility:Insoluble in water, soluble in phenethyl alcohol, chloroform, glycerol, lipids.

    R)-(+)-Lipoic acid CAS 1200-22-2

    Packing: Packed in 5kg/25kg cardboard drums lined with polyethylene bags and kraft paper bags.

    Storage: Should be sealed and shaded, stored in low temperature (<30℃) dry, cool, well-ventilated place.

    Production methodprocess of R)-(+)-Lipoic acid Powder

    • Taking ethyl 6,8-dichlorooctanoate as the starting material, through thiosulfuration, cyclization and hydrolysis, the racemate α-lipoic acid is obtained (U.S.2792406,1957; U.S.3223712,1965), and then R-lipoic acid can be obtained by splitting with a splitting agent, and the yield of this step is only 45%. Moreover, S-lipoic acid is not easy to be converted into R.S-type or R-type, which wastes half of the resources and makes R)-(+)-Lipoic acid Powder
    • The cost of R)-(+)-Lipoic acid Powder is expensive. Methyl 6,8-dihydroxyoctanoate or methyl 6-hydroxy-8-chlorooctanoate was used as the starting material to make methanesulfonate, and then stereoselectively converted into R-lipoic acid (U.S. 5869713, G. Bringmann, J. Paust Z. Naturforschung 54b,661-665, 1999), but the process was more complicated, and was not easy to obtain R)-(+)-Lipoic acid CAS 1200-22-2.
    • Hydrolysis of ethyl racemic 6, 8-dichlorooctanoate to (±)dichlorooctanoic acid (DCA), salting with (-)ephedrine, splitting, rethiolation, cyclization (Acker et al., J. Am. Chem. Soc., 76,6483,1954), which is basically cost-saving, but still leaves about 50% of S-(-)-6, 8-dichlorooctanoic acid unutilized at a higher cost。
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