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Hydrochlorothiazide powder Raw Materials CAS 58-93-5
Product Overview:
Hydrochlorothiazide powder, also known as dihydrochlorothiazide, dihydrochlorothiazide, is a thiazide diuretic, white crystalline powder, odorless, slightly bitter. Insoluble in water or chloroform, soluble in acetone, slightly soluble in ethanol, soluble in sodium hydroxide solution, but easily hydrolyzed. It has a moderate diuretic effect. Hydrochlorothiazide also has antihypertensive and antidiuretic effects. It is suitable for all kinds of edema, especially cardiogenic edema. It can also be used as an antihypertensive drug for the treatment of mild and medium hypertension.
Hydrochlorothiazide powder Raw Materials CAS 58-93-5 Attributes
MF:C7H8ClN3O4S2
MW:297.74
EINECS:200-403-3
Specification:Hydrochlorothiazide powder
Sample:Hydrochlorothiazide powder
Brand:Hydrochlorothiazide powder
Appearance: powder
Storage: Cool Dry Place
Brand: chemical Raw Materials
Shelf Life: 2 Years
Test Method: HPLC
Hydrochlorothiazide powder Raw Materials CAS 58-93-5 Details
Uses and synthesis of Hydrochlorothiazide powder
Hydrochlorothiazide white crystalline powder, odorless, slightly bitter taste. Insoluble in water or chloroform, soluble in acetone, slightly soluble in ethanol, soluble in sodium hydroxide solution, but easily hydrolyzed. Hydrochlorothiazide powder is a diuretic and antihypertensive drug. It is mainly suitable for cardiogenic edema, hepatogenic edema and renal edema
Applications/Functions of Hydrochlorothiazide powder
- Hydrochlorothiazide powder is a typical representative of effective diuretics in thiazines, and ranked first in the sales of drugs in the United States in 1985. Because it is easy to take, has a medium effect, and is suitable for various edema, it is the most common clinical adverse reaction due to potassium drainage, and potassium salt needs to be added when applied.
- Hydrochlorothiazide mainly inhibits the reabsorption of Na+ and Cl- at the proximal end of the distal tubule, which increases the excretion of sodium chloride by the kidney and produces diuretic effect, and is a medium effect diuretic. Hydrochlorothiazide has antihypertensive effect, which can be enhanced when combined with Li's patch, antihypertensive Shen patch or Apociname. This product also has antidiuretic effect and can be used to treat diabetes insipidus
- A carbonic anhydrase inhibitor.
Physicochemical Property of Hydrochlorothiazide powder
Hydrochlorothiazide white crystalline powder. Soluble point 273-275℃, soluble in acetone, slightly soluble in alcohol, insoluble in water, chloroform, ether, soluble in sodium hydroxide solution, but easy to hydrolysis. It tastes slightly bitter.
Production methodprocess of Hydrochlorothiazide powder
Hydrochlorothiazide powder was prepared from m-chloroaniline by chlorosulfonation to 5-chloro-2, 4-chlorosulfonanilide, then by ammonia reaction to 5-chloro-2, 4-aminosulfonanilide, and finally by distortion of formaldehyde.
