Nystatin powder Raw Materials CAS 1400-61-9

MF:C47H75NO17

MW:926.09

EINECS:215-749-0

Specification:99% min Nystatin powder

Sample:Nystatin powder

Appearance:white powder

Storage: Cool Dry Place

Brand:Ausreson

Shelf Life: 2 Years

Test Method: HPLC

Uses and synthesis of Nystatin powder

Nystatin powder, also known as mycin or mikodine, is an antifungal drug. It is yellow or yellowish brown powder with special odor and moisture-inducing properties. Slightly soluble in water, methanol, ethanol, insoluble in acetone, ether and chloroform. It is unstable to air, light, heat, water, acid or alkali. Antifungal antibiotics. Nystatin is a polyene antifungicin with conjugated polyene macrolide structure, which can inhibit the activity of fungi but has no inhibitory effect on bacteria. Nystatin binds to sterols on fungal cell membranes and causes changes in cell membrane permeability, resulting in leakage of important cell contents and plays an antifungal role.

Functions of Nystatin powder

1. Nystatin powder is a polyene antifungal antibiotic with strong pro-inflammatory properties.
2. A polyene antifungal drug containing three bioactive ingredients: A1, A2, and A3, with powerful pro-inflammatory properties. Nystatin is mainly used for candida albicans infection of skin mucous membrane, mouth, intestine and vagina, high concentration has bactericidal effect.
3. Nystatin has a broad spectrum of antifungal activity, and its bacterial spectrum and antibacterial mechanism are similar to amphotericin B. It has high antibacterial activity against Candida, Cryptococcus neoformans, Aspergillus, mucor, microspora, histoplasma perfringens, Blastomyces dermatitis and dermatophyton. Nystatin powder is mainly used for candida albicans infection of skin mucous membrane, mouth and vagina.

Application of Nystatin powder

I. Medical field

1. Skin and mucous membrane infections

Topical preparations (ointments, vaginal suppositories) are commonly used for the treatment of cutaneous candidiasis (e.g., interdigital rash, diaper rash) and vulvar and vaginal candida infections.

Topical treatment of oral Candida infections (e.g. thrush), using a suspension applied to the affected area.

2. Digestive tract infections

For GI candidiasis (e.g., intestinal infections), oral administration can inhibit fungal growth, but dosage should be carefully monitored to avoid gastrointestinal reactions (e.g., diarrhea, vomiting).

3. Other superficial infections

It is effective in localized infections caused by sensitive fungi such as Cryptococcus, Aspergillus, Trichophyton, etc., but ineffective in deep or systemic fungal infections.

Second, laboratory and pharmaceutical applications

Antifungal mechanism research: by binding sterols on the fungal cell membrane, change the membrane permeability leading to leakage of contents, commonly used in fungal drug resistance or synergy research.

Antibiotic complex development: as a raw material for polyene antifungal drugs, used in the preparation of antimycotic antimicrobials.

Cell Culture Aid: Used in the laboratory as an ion channel modulator for cell culture testing.

Physicochemical Property of Nystatin powder

Nystatin powder Yellow or yellowish brown powder with special odor and moisture-inducing properties. Slightly soluble in water, methanol, ethanol, insoluble in acetone, ether and chloroform. Nystatin is unstable to air, light, heat, water, acid or base.

What is the closest over the counter for nystatin?

Nystatin is only available by prescription and treats non-vaginal skin infections caused by Candida yeasts. Clotrimazole is available over the counter (OTC) and treats yeasts and molds that cause vaginal yeast infections, athlete's foot, jock itch, and more.