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Tenofovir disoproxil fumarate powder Raw Materials CAS 202138-50-9
Product Overview:
Tenofovir disoproxil fumarate powder, as a nucleotide reverse transcriptase inhibitor, is an oral ring-opening nucleotide phosphate prodrug that is rapidly transformed into tenofovir after oral absorption. Due to its high bioavailability, proven efficacy and good tolerability, Tenofovir disoproxil fumarate is now the recommended first-line anti-HIV drug with the highest sales volume. The synthesis method of Tenofovir fumarate has been reported in patent literature, but there are some problems such as excessive impurities in some intermediates, low optical purity, difficult operation, low yield, unqualified fumaric acid content and not suitable for industrial production.
Tenofovir disoproxil fumarate powder Raw Materials CAS 202138-50-9 Attributes
MF:C23H34N5O14P
MW:635.52
EINECS:687-766-5
Specification:Tenofovir disoproxil fumarate powder
Sample:Tenofovir disoproxil fumarate powder
Brand:Tenofovir disoproxil fumarate powder
Appearance: powder
Storage: Cool Dry Place
Brand: chemical Raw Materials
Shelf Life: 2 Years
Test Method: HPLC
Tenofovir disoproxil fumarate powder Raw Materials CAS 202138-50-9 Details
Uses and synthesis of Tenofovir disoproxil fumarate powder
Tenofovir disoproxil fumarate powder, as a nucleotide reverse transcriptase inhibitor, is an oral ring-opening nucleotide phosphate prodrug that is rapidly transformed into tenofovir after oral absorption. Due to its high bioavailability, proven efficacy and good tolerability, Tenofovir disoproxil fumarate is now the recommended first-line anti-HIV drug with the highest sales volume. The synthesis method of Tenofovir fumarate has been reported in patent literature, but there are some problems such as excessive impurities in some intermediates, low optical purity, difficult operation, low yield, unqualified fumaric acid content and not suitable for industrial production.
Applications/Functions of Tenofovir disoproxil fumarate powder
Nucleotide reverse transcriptase inhibitor, a prodrug of Tenofovir (PMPA, 2), Tenofovir disoproxil fumarate powder is mainly used clinically for the treatment of human immunodeficiency virus (HIV) infection.
Physicochemical Property of Tenofovir disoproxil fumarate powder
Tenofovir disoproxil fumarate is a white or quasi-white crystalline powder. No odor. Soluble in dimethylformamide and soluble in methanol; Slightly soluble in water and acetonitrile. Melting point 113~118℃
Production methodprocess of Tenofovir disoproxil fumarate powder
