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Irbesartan powder Raw Materials CAS 138402-11-6
Product Overview:
Irbesartan powder is a receptor inhibitor of AngiotensinⅡ (AngⅡ). By selectively blocking the binding of AngⅡ to AT1 receptor, Irbesartan powder can inhibit vasoconstriction and release of aldosterone, resulting in antihypertensive effects. Irbesartan does not inhibit angiotensin-converting enzyme (ACE), renin, or other hormone receptors, nor does it inhibit ion channels involved in blood pressure regulation and sodium balance. Irbesartan can also reduce the electrical remodeling of myocardium, thus reducing the mortality of hypertensive patients, and is currently the most effective drug for the treatment of hypertension and cardiovascular diseases.
Irbesartan powder Raw Materials CAS 138402-11-6 Attributes
MF:C25H28N6O
MW:428.53
EINECS:604-078-2
Specification:Irbesartan powder
Sample:Irbesartan powder
Brand:Irbesartan powder
Appearance: powder
Storage: Cool Dry Place
Brand: chemical Raw Materials
Shelf Life: 2 Years
Test Method: HPLC
Irbesartan powder Raw Materials CAS 138402-11-6 Details
Uses and synthesis of Irbesartan powder
Irbesartan powder is a receptor inhibitor of AngiotensinⅡ (AngⅡ). By selectively blocking the binding of AngⅡ to AT1 receptor, Irbesartan powder can inhibit vasoconstriction and release of aldosterone, resulting in antihypertensive effects. Irbesartan does not inhibit angiotensin-converting enzyme (ACE), renin, or other hormone receptors, nor does it inhibit ion channels involved in blood pressure regulation and sodium balance. Irbesartan can also reduce the electrical remodeling of myocardium, thus reducing the mortality of hypertensive patients, and is currently the most effective drug for the treatment of hypertension and cardiovascular diseases.
Applications/Functions of Irbesartan powder
- Irbesartan powder Antihypertensive medication. Angiotensin Ⅱ-l type (AⅡ1) -receptor antagonist. Used to treat high blood pressure.
- As a long-acting antihypertensive drug, Irbesartan is the first-line drug for hypertension. Besides treating hypertension, Irbesartan has shown good efficacy for Parkinson's disease, diabetic nephropathy and other diseases.
Physicochemical Property of Irbesartan powder
Production methodprocess of Irbesartan powder
1-(fluorenyl methoxycarbonyl amino) cyclopentarcarboxylic acid (I) is condensed with compound (Ⅳ), the resulting product removes the protective group on N to obtain compound (Ⅷ), and then reacts with triethyl protovalerate to obtain Irbesartan powder.
