2mg 4mg Irsogladine maleate powder Raw Materials

2mg 4mg Irsogladine maleate powder Raw Materials

CAS:84504-69-8

MF:C13H11Cl2N5O4

MW:372.16

EINECS:/

Specification:99% min Irsogladine maleate powder

Sample:Irsogladine maleate powder

Keywords:Irsogladine maleate

Appearance: white powder

Storage: Cool Dry Place

Brand:Ausreson

Shelf Life: 2 Years

Test Method: HPLC

Uses and synthesis of Irsogladine maleate powder

Irsogladine maleate powder has an anti-ulcer effect, which can strengthen the adhesion between epithelial cells of gastric mucosa, enhance the stability of the mucosa itself, play a cellular defense role, and increase the blood flow of gastric mucosa. Does not affect basic gastric acid secretion, does not stimulate acid secretion. Irsogladine maleate has been shown to suppress or cure experimental gastritis in compliance with dosage.

Functions of Irsogladine maleate powder

1. Irsogladine maleate powder is used for gastric ulcers and can also be used to improve gastric mucosal lesions during acute and chronic gastritis
2. Irsogladine maleate is a drug used to treat gastric ulcers
3. Irsogladine maleate has an anti-ulcer effect, can strengthen the adhesion between epithelial cells of gastric mucosa, enhance the stability of the mucosa itself, play a cellular defense role, and increase the blood flow of gastric mucosa. Does not affect basic gastric acid secretion, does not stimulate acid secretion. Irsogladine maleate powder has been shown to suppress or cure experimental gastritis in compliance with dosage.

Pharmacological Action of Irsogladine maleate powder

Anti-ulcer effect: Isoladine maleate can effectively inhibit gastric acid secretion and protect the gastric mucosa from damage, thereby promoting the healing of gastric ulcers.
Anti-inflammatory effect: Studies have shown that Isoladine may have a certain anti-inflammatory effect and help reduce the inflammatory response of the gastric mucosa.

Mechanism of gastric mucosal protection
Enhance mucosal stability by enhancing gastric mucosal inter-epithelial cell binding, inhibiting cell peeling and gap expansion.
Increase gastric mucosal blood flow, promote mucosal regeneration and healing of ulcer margins.
Increase intracellular cyclic adenosine monophosphate (cAMP) level and enhance defense function without affecting basal gastric acid secretion.

Antiulcer and repair effects
Inhibits experimental gastric ulcers induced by ethanol, indomethacin and aspirin with dose-dependent efficacy.
Accelerates mucosal repair by promoting the production of prostaglandins, reduced glutathione and mucus glycoproteins

Production method of Irsogladine maleate powder.

Synthesis of key intermediates
Step 1: Take 2,5-dichlorotoluene as raw material, oxidize to form 2,5-dichlorobenzoic acid (reaction between aqueous pyridine solution and potassium permanganate).
Step 2: 2,5-dichlorobenzoic acid was reacted with sulfamic acid and urea by high temperature melting to produce 2,5-dichlorobenzonitrile.

Synthesis of target product
Step 3: Condensation of 2,5-dichlorobenzonitrile with cyanoguanidine and potassium hydroxide in ethylene glycol to form isoradine.
Salt formation treatment: Isoradine was reacted with maleic acid to finalize Isoradine maleate