Yohimbine Hcl CAS 65-19-0 Powder

CAS: 65-19-0

MF: C21H27ClN2O3

Specification​: 99% min

Sample: Yohimbine Hydrochloride Powder

Brand: Global Chemical

Appearance: Yohimbine Hydrochloride Powder

Storage: Cool Dry Place

Shelf Life: 2 Years

Test Method: HPLC

Yohimbine Hydrochloride Usage and Synthesis:

Yohimbine Hydrochloride Molecular formula C21H26N2O3HCL, white to milky white fine powder, slightly fragrant, bitter and astringent, melting point 288℃~290℃, as a chemical reagent, soluble in chloroform, soluble in methanol, ethanol, slightly soluble in water. ~290℃, as a chemical reagent, easily soluble in chloroform, soluble in methanol, ethanol, slightly soluble in water. Plant source wild in the African plant Yohimbe （The extract of the dried bark of the African plant Yohimbe (CorynanteYohimbe) or the bark of the West African plant Corynaceae. Its pharmacological effects are characterized by an increase in sexual muscle tone, non-destructive urinary suppressant effect, and an increase in muscle energy. It is also used to accelerate muscle energy metabolism and increase energy supply. It is used clinically in single doses for the treatment of all types of male impotence and hypogonadism. Yohimbine hydrochloride may also produce psychoactive Yohimbine hydrochloride may also produce psychoactive stimulant effects and increase sexual desire.

Pharmacokinetics of Yohimbine Hydrochloride:

Yohimbine Hydrochloride is soluble in water and is rapidly absorbed at t1/20.5h (oral) and 0.68h (intravenous). Elimination data for intravenous administration were consistent with a two-compartment model. The elimination rates were 55.9 ml/min*kg (sedation) and 9.77 ml/min*kg (oral), with rapid entry into the brain after sedation and drug clearance mainly in the liver, in addition to extrahepatic metabolic pathways The concentration in urine is 0.5~1% and excreted as a prototype. Geriatric patients, psychiatric patients, patients with gastric and duodenal ulcers, and cardiac patients should be used with caution. The mechanism of action is to selectively The mechanism of action is to selectively block presynaptic α2 receptors, promote the release of norepinephrine, so that the cavernous nerve endings release more norepinephrine, reduce penile venous reflux, and facilitate erection. It can also increase the secretion of sexual fluids.

Clinical Application of Yohimbine Hydrochloride:

Yohimbine Hydrochloride is an α2-adrenergic receptor inhibitor that blocks presynaptic or postsynaptic α-2 adrenergic receptors, causing the release of norepinephrine and dopamine. It blocks pre- or postsynaptic α-2-adrenergic receptors, causing the release of norepinephrine and dopamine. It selectively blocks presynaptic α2-adrenergic receptors, causing vascular smooth muscle dilation, and it increases peripheral parasympathetic tone and decreases sympathetic tone. It also increases peripheral parasympathetic tone and decreases sympathetic tone, while penile erection depends on parasympathetic stimulation; therefore, yohimbine hydrochloride may increase blood flow to the cavernous sinus of the penis by dilating the artery into the stem Therefore, yohimbine hydrochloride may increase blood flow to the cavernous sinus of the penis by dilating the arteries into the penis, resulting in an erection. It is used clinically in single doses to treat all types of impotence and hypogonadism in men. Click here to learn more about us.