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Nitrilotriacetic acid powder Raw Materials CAS 139-13-9
Product Overview:
Nitrilotriacetic acid powder, is an organic compound, the chemical formula is C6H9NO6, Nitrilotriacetic acid CAS 139-13-9 is white crystalline powder, slightly soluble in hot water, soluble in ammonia, sodium hydroxide solution, Nitrilotriacetic acid Raw Materials Mainly used as complexing agent, catalyst, stabilizer, descaling agent, electroplating agent, colour photographic developer, polycarboxylic acid chelating agent.
Nitrilotriacetic acid powder Raw Materials CAS 139-13-9 Attributes
Low Price Nitrilotriacetic acid powder CAS 139-13-9
CAS:139-13-9
MF:C6H9NO6
MW:191.14
EINECS:205-355-7
Specification:995 min Nitrilotriacetic acid powder
Sample:Nitrilotriacetic acid powder
Appearance: white powder
Storage: Cool Dry Place
Brand: Ausreson
Shelf Life: 2 Years
Test Method: HPLC
Nitrilotriacetic acid powder Raw Materials CAS 139-13-9 Details
Uses and synthesis of Nitrilotriacetic acid powder
Nitrilotriacetic acid powder is an organic compound with the chemical formula C6H9NO6, Nitrilotriacetic acid CAS 139-13-9 is a white crystalline powder, slightly soluble in hot water, soluble in ammonia, sodium hydroxide solution, Nitrilotriacetic acid Raw Materials is mainly used as complexing agent, catalyst, stabilizer, descaling agent, electroplating agent, colour photographic developer, chelating agent for polycarboxylic acid.
Functions of Nitrilotriacetic acid powder
Nitrilotriacetic acid powder is a good colour fixing agent in dyestuff industry, a stabilizer in styrene production, a catalyst and a complexing agent in polyurethane foam production.
Nitrilotriacetic acid CAS 139-13-9 Used as complexing reagent, also used in cyanide-free plating
Nitrilotriacetic acid Raw Materials Used as complexing reagent in electroplating industry, replacing sodium cyanide for cyanide-free plating. It is also widely used as metal ion chelating agent in textile and paper making industry.
Applications of Nitrilotriacetic acid powder.
1. Industrial Applications
Detergents and Antiscalants: As a component of phosphorus-free detergents, it softens water by chelating calcium and magnesium ions.
Electroplating and Chemical Plating: Replaces cyanide for cyanide-free electroplating to improve the uniformity of metal coatings.
Dyes and Printing: As a color fixative to enhance dye stability or adjust ink viscosity.
Plastics and Foam Production: As a catalyst in polyurethane foaming to accelerate gelation reactions.
2. Biomedical Applications
Protein Purification: NTA-Ni²⁺ resin specifically binds to target proteins through histidine tags (His-tags).
Medical Imaging: Combined with near-infrared dyes (such as ICG) to form probes for in vivo tumor targeting imaging.
Drug Carriers: PEG-modified NTA (such as mPEG-NTA) can improve drug water solubility and targeting.
3. Materials Science
Nanomaterial preparation: Thiol PEG-NTA (SH-PEG-NTA) is used for the synthesis and surface functionalization of gold nanoparticles.
Polymer modification: As a linker to enhance the water solubility of materials or reduce immunogenicity
Self-assembled monolayer (SAM): NTA-SAM is used for biomolecule immobilization or metal ion capture.
4. Other fields
Agriculture: Regulate crop growth cycles (such as rice and tomatoes) or as a growth inhibitor.
Environmental protection: Strong biodegradability (2-week decomposition rate 82-88%), used for heavy metal wastewater treatment
Pharmacological Action of Nitrilotriacetic acid powder
1. Metal ion chelation
As an aminocarboxylic acid chelating agent, NTA can form stable water-soluble complexes with a variety of metal ions (such as calcium, magnesium, nickel, etc.), thereby regulating the balance of metal ions in the body.
In the purification of His-tagged proteins, the NTA-Ni²⁺ complex can specifically bind to histidine residues for protein separation and imaging.
2. Biomedical applications
Anticoagulation and detoxification : indirectly affecting the coagulation process by chelating calcium ions, or used as an antidote for heavy metal poisoning.
Drug carrier : combined with fluorescent dyes (such as ICG) to form probes for in vivo imaging or targeted delivery.
3. Industrial and biochemical auxiliary functions
As a color fixative in the dye industry, it enhances the stability of dyes by chelating metal ions.
As a catalyst for polyurethane foam production, it regulates the reaction rate
Production methodprocess of Nitrilotriacetic acid powder
Nitrilotriacetic acid powder is obtained by reacting chloroacetic acid with sodium hydroxide to form sodium chloroacetate, then ammonium chloride to form sodium aminotriacetate, and then acidification.
1. Chloroacetic acid route (traditional process)
Steps: Chloroacetic acid first reacts with sodium hydroxide to form sodium chloroacetate, then reacts with ammonium chloride to form sodium aminotriacetate, and finally acidifies to obtain the NTA finished product.
Features: The raw materials are easily available but involve strong acids/strong bases, and corrosive byproducts need to be treated.
2. Hydroxyacetonitrile route (clean process)
Steps: Hydroxyacetonitrile is added dropwise to a mixture of ammonia water and sodium hydroxide, heated and hydrolyzed to directly generate NTA sodium salt, and purified after acidification.
Features: Mild reaction conditions, few byproducts, in line with the trend of green chemistry
